Y chromosome microdeletions: Implications for assisted conception

Medical Journal of Australia

Volumn 185, Issue 8, 2006, Pages 433-434

  Cram, David S ^a,b   Osborne, Elissa ^b   McLachlan, Robert I ^c  

^a EPWORTH HOSPITAL   (Australia)

^b MONASH UNIVERSITY   (Australia)

^c HUDSON INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

GENOMIC DNA;

ANDROGEN DEFICIENCY; AUSTRALIA; AZOOSPERMIA; CHROMOSOME BAND; CHROMOSOME DELETION Y; CHROMOSOME YP; CHROMOSOME YQ; CLINICAL PRACTICE; CONCEPTION; DECISION MAKING; DISEASE SEVERITY; DNA MICROARRAY; DNA SEQUENCE; EDITORIAL; FERTILIZATION IN VITRO; GENE EXPRESSION; GENE IDENTIFICATION; GENETIC COUNSELING; GENOTYPE PHENOTYPE CORRELATION; HOMOLOGOUS RECOMBINATION; HUMAN; INFERTILITY THERAPY; INTRACYTOPLASMIC SPERM INJECTION; KARYOTYPE; MALE; MALE INFERTILITY; MEDICAL RESEARCH; OLIGOSPERMIA; PRACTICE GUIDELINE; RISK ASSESSMENT; RISK FACTOR; SEQUENCE ANALYSIS; SERTOLI CELL; SPERM DONOR; SPERMATOZOON COUNT; SPERMATOZOON DENSITY; TESTIS BIOPSY; TESTIS TUMOR; VERTICAL TRANSMISSION;

EID: 33750191520     PISSN: 0025729X     EISSN: None     Source Type: Journal    
DOI: 10.5694/j.1326-5377.2006.tb00641.x     Document Type: Editorial

References (19)

1. Baker HWG. Clinical evaluation and management of testicular disorders in the adult. In: Burger H, de Kretser D, editors. The testis. 2nd ed. New York: Raven Press, 1989.
2. Jequier AM. Clinical andrology - still a major problem in the treatment of infertility. Hum Reprod 2004; 19: 1245-1249.
3. Foresta C, Moro E, Ferkin A. Y chromosome microdeletions and alterations of spermatogenesis. Endocr Rev 2001; 22: 226-239.
4. Skaletsky H, Kuroda-Kawaguchi T, Minx PJ, et al. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. Nature 2003; 423: 825-837.
5. Palermo G, Joris H, Devroey P, Van Steirteghem AC. Pregnancies after intracytoplasmic injection of single spermatozoon into an oocyte. Lancet 1992; 340: 17-18.
6. Sousa M, Cremades N, Siva J, et al. Predictive value of testicular histology in secretory azoospermic subgroups and clinical outcome after microinjection of fresh and frozen-thawed sperm and spermatids. Hum Reprod 2002; 17: 1800-1810.
7. Tiepolo L, Zuffardi O. Localization of factors controlling spermatogenesis in the nonfluorescent portion of the human Y chromosome long arm. Hum Genet 1976; 34: 119-124.
8. Vogt PH. Human chromosome deletions in Yq11, AZF candidate genes and male infertility: history and update. Mol Hum Reprod 1998; 4: 739-744.
9. Repping S, Skaletsky H, Brown L, et al. Polymorphism for a 1.6-Mb deletion of the human Y chromosome persists through balance between recurrent mutation and haploid selection. Nat Genet 2003; 35: 247-251.
10. McLachlan R, Rajpert-De Meyts E, Hoei-Hansen CE, et al. Histological evaluation of the human testis: approaches to optimizing the clinical value of the assessment. Hum Reprod 2006 Aug 3; Epub ahead of print.
11. Giachini C, Guarducci E, Longepied G, et al. The gr/gr deletion(s): a new genetic test in male infertility? J Med Genet 2005; 42: 497-502.
12. Lynch M, Cram DS, Reilly A, et al. The Y chromosome gr/gr subdeletion is associated with male infertility. Mol Hum Reprod 2005; 11: 507-512.
13. McElreavey K, Ravel C, Chantot-Bastaraud S, Siffroi JP. Y chromosome variants and male reproductive function. Int J Androl 2006; 29: 298-303.
14. Cram DS, Ma K, Bhasin S, et al. Y chromosome analysis of infertile men and their sons conceived through intracytoplasmic sperm injection: vertical transmission of deletions and rarity of de novo deletions. Fertil Steril 2000; 74: 909-915.
15. Simoni M, Bakker E, Krausz C. EAA/EMQN best practice guidelines for molecular diagnosis of y-chromosomal microdeletions. State of the art 2004. Int J Androl 2004; 27: 240-249.
16. Krausz C, Quintana-Murci L, McElreavey K. Prognostic value of Y deletion analysis: what is the clinical prognostic value of Y chromosome microdeletion analysis? Hum Reprod 2000; 15: 1431-1434.
17. Andersson AM, Jorgensen N, Frydelund-Larsen L, et al. Impaired Leydig cell function in infertile men: a study of 357 idiopatic infertile men and 318 proven fertile controls. J Clin Endocrinol Metab 2004; 89: 3158-3160.
18. Jacobsen R, Bostofte E, Engholm G, et al. Risk of testicular cancer in men with abnormal semen characteristics: cohort study. BMJ 2000; 321: 789-792.
19. Stouffs K, Lissens W, Tournaye H, et al. The choice and outcome of the fertility treatment of 38 couples in whom the male partner has a Yq microdeletion. Hum Reprod 2005; 20: 1887-1896.