The current status of thromboprophylaxis after trauma: A story of confusion and uncertainty

American Surgeon

Volumn 72, Issue 9, 2006, Pages 757-763

  Velmahos, George C ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEPARIN; LOW MOLECULAR WEIGHT HEPARIN;

ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DEEP VEIN THROMBOSIS; DEVICE; ECHOGRAPHY; HUMAN; INJURY; LEG COMPRESSION; LUNG EMBOLISM; PHLEBOGRAPHY; PROTECTIVE CLOTHING; RANDOMIZED CONTROLLED TRIAL; RISK ASSESSMENT; THROMBOSIS PREVENTION; INTERMITTENT PNEUMATIC COMPRESSION DEVICE; REVIEW; UTILIZATION REVIEW; VEIN THROMBOSIS;

CLINICAL TRIALS; HEPARIN; HEPARIN, LOW-MOLECULAR-WEIGHT; HUMANS; INTERMITTENT PNEUMATIC COMPRESSION DEVICES; VENOUS THROMBOSIS; WOUNDS AND INJURIES;

EID: 33750097770     PISSN: 00031348     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (53)

1. Velmahos GC. Prevention of Venous Thromboembolism after Injury. Evidence Report/Technology Assessment Number 22. Agency for Health Research and Quality, No. 01-E004, 2000.
2. Kakkar VV, Corrigan T, Spindler J, et al. Efficacy of low doses of heparin in prevention of deep-vein thrombosis after major surgery. A double-blind, randomized trial. Lancet 1972;2:101-6.
3. Kakkar VV, Corrigan TP, Fossard DP, et al. Prevention of fatal postoperative pulmonary embolism by low doses of heparin. An interventional multicentre trial. Lancet 1975;2:45-51.
4. Daniels CE, Montori VM, Dupras DM. Effect of publication bias on retrieval bias. Acad Med 2002;77:266-7.
5. Fisher CG, Blachut A, Salvian AJ, et al. Effectiveness of pneumatic leg compression devices for the prevention of thromboembolic disease in orthopedic trauma patients: a prospective, randomized study of compression along versus no prophylaxis. J Orthop Trauma 1995;9:1-7.
6. Knudson MM, Morabito D, Paiement GD, Schackleford S. Use of low molecular weight heparin in preventing thromboembolism in trauma patients. J Trauma 1996;41:446-59.
7. Ginzburg E, Cohn SM, Lopez K, et al. Randomized clinical trial of intermittent pneumatic compression and low molecular weight heparin in trauma. Br J Surg 2003;90:1338-44.
8. Geerts WH, Jay RM, Code KI, et al. A comparison of low-dose heparin with low-molecular-weight heparin as prophylaxis against venous thromboembolism after major trauma. N Engl J Med 1996;335:701-7.
9. Geerts WH, Code KI, Jay RM, et al. A prospective study of venous thromboembolism after major trauma. N Engl J Med 1994; 331:1601-6.
10. Norwood SH, McAuley CE, Berne JD, et al. A potentially expanded role for enoxaparin in preventing venous thromboembolism in high risk blunt trauma patients. J Am Coll Surg 2001;192: 161-7.
11. Shuerer DJE, Whinney RR, Freeman BD, et al. Evaluation of the applicability, efficacy, and safety of a thromboembolic event prophylaxis guideline designed for quality improvement of the traumatically injured patient. J Trauma 2005;58:731-9.
12. Britt LD, Zolfaghari D, Kennedy E, et al. Incidence and prophylaxis of deep vein thrombosis in a high risk trauma population. Am J Med 1996;172:13-4.
13. Piotrowski JJ, Alexander J, Brandt CP, et al. Is deep venous thrombosis surveillance warranted in high-risk trauma patients? Am J Surg 1996;172:210-3.
14. Spain DA, Bergamini TM, Hoffman JF, et al. Comparison of sequential compression devices and foot pumps for prophylaxis of deep venous thrombosis in high-risk trauma patients. Am Surg 1998;64:525-6.
15. Schwarcz TH, Quick RC, Minion DH, et al. Enoxaparin treatment in high-risk trauma patients limits the utility of surveillance venous duplex scanning. J Vasc Surg 2001;34:447-52.
16. Knudson MM, Collins JA, Goodman SB, McCrory DW. Thromboembolism following multiple trauma. J Trauma 1992;32: 2-11.
17. Knudson MM, Lewis FR, Clinton A, et al. Prevention of venous thromboembolism in trauma patients. J Trauma 1994;37: 480-7.
18. Merli G and the Spinal Cord Injury Thromboprophylaxis Investigators. Prevention of venous thromboembolism in the acute treatment phase after spinal cord injury: a randomized, multicenter trial comparing low-dose heparin plus intermittent pneumatic compression with enoxaparin. J Trauma 2003;54:1116-26.
19. Kurtoglou M, Yanar H, Bilsel Y, et al. Venous thromboembolism prophylaxis after head and spinal trauma: intermittent pneumatic compression devices versus low molecular weight heparin. World J Surg 2004;28:807-11.
20. Fuchs S, Heyse T, Rudofsky G, et al. Continuous passive motion in the prevention of deep-vein thrombosis. A randomized comparison in trauma patients. J Bone Joint Surg Br 2005;87-B: 1117-22.
21. Stannard JP, Lopez-Ben RR, Volgas DA, et al. Prophylaxis against deep-vein thrombosis following trauma: a prospective, randomized comparison of mechanical and pharmacologic prophylaxis. J Bone Join Surg 2006;88-A:261-6.
22. Shackford SR, Davis JW, Hollingworth-Fridlund P, et al. Venous thromboembolism in patients with major trauma. Am J Surg 1990;159:365-9.
23. Ruiz AJ, Hill SL, Berry RE. Heparin, deep venous thrombosis, and trauma patients. Am J Surg 1991;162:159-62.
24. Burns GA, Cohn SM, Frumento RJ, et al. Prospective ultrasound evaluation of venous thrombosis in high-risk trauma patients. J Trauma 1993;35:405-8.
25. Decousous H, Leizorvicz A, Parent F, et al. A clinical trial of vena caval filters in the prevention of pulmonary embolism in patients with proximal deep-vein thrombosis. N Engl J Med 1998; 338:409-15.
26. Wojcik R, Cipolle MD, Fearen I, et al. Long-term follow-up of trauma patients with vena caval filter. J Trauma 2000;49: 839-43.
27. Upchurch GR, Demling RH, Davies J, et al. Efficacy of subcutaneous heparin in prevention of venous thromboembolic events in trauma patients. Am Surg 1995;61:749-55.
28. Napolitano LM, Garlapati VS, Heard SO, et al. Asymptomatic deep venous thrombosis in the trauma patient: is an aggressive screening protocol justified? J Trauma 1995;39:651-9.
29. Greenfield LJ, Proctor MC, Rodriguez JL, et al. Post-trauma thromboembolism prophylaxis. J Trauma 1997;42:100-3.
30. Headrick JR, Barker DE, Pate LM, et al. The role of ultrasonography and inferior vena cava filter placement in high-risk trauma patients. Am Surg 1997;63:1-8.
31. Velmahos GC, Nigro J, Tatevossian R, et al. Inability of an aggressive policy of thromboprophylaxis to prevent deep venous thrombosis (DVT) in critically injured patients: are current methods of DVT prophylaxis insufficient? J Am Coll Surg 1998;187: 529-33.
32. Major KM, Wilson M, Nishi GK, et al. The incidence of thromboembolism in the surgical intensive care unit. Am Surg 2003;69:857-61.
33. Meissner MH, Chandler WL, Elliott JS. Venous thromboembolism in trauma: a local manifestation of systemic hypercoagulability? J Trauma 2003;54:224-31.
34. Velmahos GC, Toutouzas KG, Brown C, et al. Thromboprophylaxis does not protect severely injured patients against pulmonary embolism. Am Surg 2004;70:893-6.
35. Schultz DJ, Brasel KJ, Washinton L, et al. Incidence of asymptomatic pulmonary embolism in moderately to severely injured trauma patients. J Trauma 2004;56:727-33.
36. Steele N, Dodenhoff RM, Ward AJ, Morse MH. Thromboprophylaxis in pelvic and acetabular trauma surgery. The role of early treatment with low-molecular-weight heparin. J Bone Joint Surg 2005;87-B:209-12.
37. Winchell RJ, Hoyt DB, Walsh JC, et al. Risk factors associated with pulmonary embolism despite routine prophylaxis: implications for improved protection. J Trauma 1994;37:600-6.
38. Spain DA, Richardson JD, Polk HC Jr, et al. Venous thromboembolism in the high-risk trauma patient: do risks justify aggressive screening and prophylaxis? J Trauma 1997;42:463-9.
39. Knudson MM, Ikossi DG, Khaw L, et al. Thromboembolism after trauma. An analysis of 1602 episodes from the American College of Surgeons National Trauma Data Bank. Ann Surg 2004; 240:490-8.
40. Geerts WH, Pineo GF, Heit JA, et al. Prevention of venous thromboembolism. The seventh ACCP conference on antithrombotic and thrombolytic therapy. Chest 2004;126:338S-400S.
41. Rogers FB, Cipolle MD, Velmahos G, et al. Practice management guidelines for the prevention of venous thromboembolism in trauma patients: the EAST practice management guidelines work group. J Trauma 2002;53:142-64.
42. Velmahos GC, Kern J, Chan LS, et al. Prevention of venous thromboembolism after injury: an evidence-based report. J Trauma 2000;49:132-9.
43. Rutherford EJ, Schooler WG, Sredzsienski E, et al. Optimal dosing of enoxaparin in critically ill trauma and surgical patients. J Trauma 2005;58:1167-70.
44. Priglinger U, Karth D, Geppert A, et al. Prophylactic anti-coagulation with enoxaparin: is the subcutaneous route appropriate in the critically ill? Crit Care Med 2003;31:1405-9.
45. Owings JT, Bagley M, Gosselin R, et al. Effect of critical injury on plasma antithrombin activity: low antithrombin levels are associated with thromboembolic complications. J Trauma 1996; 41:396-405.
46. Cornwell EE, Chang D, Velmahos G, et al. Compliance with sequential compression device prophylaxis in at-risk trauma patients: a prospective analysis. Am Surg 2002;68:470-3.
47. Frankel HL, FitzPatrick MK, Gaskell S, et al. Strategies to improve compliance with evidence-based clinical management guidelines. J Am Coll Surg 1999;189:533-8.
48. Velmahos GC, Oh Y, McCombs J, Oder D. An evidence-based cost-effectiveness model on methods of prevention of post-traumatic venous thromboembolism. J Trauma 2000;49:1059-64.
49. Wade WE, Chisholm MA. Deep venous thrombosis in trauma: cost analysis. Blood Coagul Fibrinolysis 2000;11:101-6.
50. Devlin JW, Petitta A, Shepard AD, Obeid FN. Cost-effectiveness of enoxaparin versus low-dose heparin for prophylaxis against venous thrombosis after major trauma. Pharmacotherapy 1998;18:1335-42.
51. Gosselin RC, Dager WE, King JH, et al. Effect of direct thrombin inhibitors, bivalirudin, lepirudin, and argatroban, on prothrombin time and INR values. Am J Clin Pathol 2004;121:593-9.
52. Kaplan RE, Czyrny JJ, Fung TS, et al. Electrical foot stimulation and implications for the prevention of venous thromboembolic disease. Thrombosis Hemostasis 2002;88:200-4.
53. Velmahos GC, Petrone P, Chan LS, et al. Electrostimulation for the prevention of deep venous thrombosis in patients with major trauma: a prospective randomized study. Surgery 2005;137: 493-8.