메뉴 건너뛰기




Volumn 2, Issue 5, 2006, Pages 643-650

Recent advances in the systemic management of colorectal cancer

Author keywords

5 fluorouracil; Bevacuzimab; Capecitabine targeted therapy; Cetuximab; Chemotherapy; Colorectal cancer; Irinotecan; Oxaliplatin

Indexed keywords

BEVACUZIMAB; CAPECITABINE; CETUXIMAB; FLUOROURACIL; FOLINIC ACID; IRINOTECAN; MONOCLONAL ANTIBODY; OXALIPLATIN; PLACEBO; UNCLASSIFIED DRUG;

EID: 33750089261     PISSN: 14796694     EISSN: 17448301     Source Type: Journal    
DOI: 10.2217/14796694.2.5.643     Document Type: Review
Times cited : (7)

References (43)
  • 1
    • 33750044629 scopus 로고    scopus 로고
    • Toms JR (Ed.): Cancer Stats Monograph 2004. Cancer Research UK, London, UK
    • Toms JR (Ed.): Cancer Stats Monograph 2004. Cancer Research UK, London, UK (2004).
    • (2004)
  • 2
    • 33750059223 scopus 로고    scopus 로고
    • Pooled analysis of fluorouracil-based adjuvant therapy for Stage II and III colon cancer: Who benefits and by how?
    • Gill S, Loprinzi CL, Sargent DJ et al.: Pooled analysis of fluorouracil-based adjuvant therapy for Stage II and III colon cancer: who benefits and by how? J. Clin. Oncol. 17, 3553-3559 (1999).
    • (1999) J. Clin. Oncol. , vol.17 , pp. 3553-3559
    • Gill, S.1    Loprinzi, C.L.2    Sargent, D.J.3
  • 3
    • 0028835122 scopus 로고
    • Intergroup study of fluorouracil plus levamisole as adjuvant therapy for Stage II/Dukes' B2 colon cancer
    • Moertel CG, Fleming TR, Macdonald JS et al.: Intergroup study of fluorouracil plus levamisole as adjuvant therapy for Stage II/Dukes' B2 colon cancer. J. Clin. Oncol. 13, 2936-2943 (1995).
    • (1995) J. Clin. Oncol. , vol.13 , pp. 2936-2943
    • Moertel, C.G.1    Fleming, T.R.2    Macdonald, J.S.3
  • 4
    • 3242657624 scopus 로고    scopus 로고
    • QUASAR: A randomised study of adjuvant chemotherapy (CT) vs observation including 3238 colorectal cancer patients
    • A3501
    • Gray RG, Barnwell J, Hills R et al.: QUASAR: a randomised study of adjuvant chemotherapy (CT) vs observation including 3238 colorectal cancer patients. Proc. Am. Soc. Clin. Oncol. 22, 245 A3501 (2004).
    • (2004) Proc. Am. Soc. Clin. Oncol. , vol.22 , pp. 245
    • Gray, R.G.1    Barnwell, J.2    Hills, R.3
  • 5
    • 0000480157 scopus 로고    scopus 로고
    • Phase III randomised trial of bolus 5HFU/leucovorin/levamisole versus 5-FU continuous infusion/levamisole as adjuvant therapy for high risk colon cancer (SWOG 9415/INT-0153)
    • Poplin E, Benedetti J, Estes N et al.: Phase III randomised trial of bolus 5HFU/leucovorin/levamisole versus 5-FU continuous infusion/ levamisole as adjuvant therapy for high risk colon cancer (SWOG 9415/ INT-0153). Proc. Am. Soc. Clin. Oncol. 19, A931 (2000).
    • (2000) Proc. Am. Soc. Clin. Oncol. , vol.19
    • Poplin, E.1    Benedetti, J.2    Estes, N.3
  • 6
    • 0038575246 scopus 로고    scopus 로고
    • Twelve weeks of protracted venous infusion of fluorouracil (5-FU) is as effective as 6 months of bolus 5-FU and folinic acid as adjuvant treatment in colorectal cancer
    • Saini A, Norman AR, Cunningham D et al.: Twelve weeks of protracted venous infusion of fluorouracil (5-FU) is as effective as 6 months of bolus 5-FU and folinic acid as adjuvant treatment in colorectal cancer. Br. J. Cancer 88, 1859-1865 (2003).
    • (2003) Br. J. Cancer , vol.88 , pp. 1859-1865
    • Saini, A.1    Norman, A.R.2    Cunningham, D.3
  • 7
    • 4444377696 scopus 로고    scopus 로고
    • Capecitabine vs bolus 5-FU/leucovorin as adjuvant therapy for colon cancer (the X-ACT study): Positive efficacy results of a Phase III trial
    • Cassidy J, Scheithauer W, McKendrick J et al.: Capecitabine vs bolus 5-FU/leucovorin as adjuvant therapy for colon cancer (the X-ACT study): positive efficacy results of a Phase III trial. J. Clin. Oncol. 22(Suppl.) 3509 (2004).
    • (2004) J. Clin. Oncol. , vol.22 , Issue.SUPPL. , pp. 3509
    • Cassidy, J.1    Scheithauer, W.2    McKendrick, J.3
  • 8
    • 10944266064 scopus 로고    scopus 로고
    • Irinotecan plus fluorouracil/leucovorin (IFL) versus fluorouracil alone (FL) in Stage III colon cancer (intergroup trial CALGB C89803)
    • Saltz LB, Niedzwiecki D, Hollis D et al.: Irinotecan plus fluorouracil/ leucovorin (IFL) versus fluorouracil alone (FL) in Stage III colon cancer (intergroup trial CALGB C89803). J. Clin. Oncol. 22(Suppl.) 3500 (2004).
    • (2004) J. Clin. Oncol. , vol.22 , Issue.SUPPL. , pp. 3500
    • Saltz, L.B.1    Niedzwiecki, D.2    Hollis, D.3
  • 9
    • 2542615200 scopus 로고    scopus 로고
    • Oxaliplatin, fluorouracil and leucovorin as adjuvant treatment for colon cancer
    • Andre T, Boni C, Mounedji-Boudiaf L et al.: Oxaliplatin, fluorouracil and leucovorin as adjuvant treatment for colon cancer. N. Eng. J. Med. 350, 2343-2351 (2004).
    • (2004) N. Eng. J. Med. , vol.350 , pp. 2343-2351
    • Andre, T.1    Boni, C.2    Mounedji-Boudiaf, L.3
  • 10
    • 0037010411 scopus 로고    scopus 로고
    • DNA markers predicting benefit from adjuvant fluorouracil in patients with colon cancer: A molecular study
    • Barrat PL, Seymour MT, Stenning SP et al.: DNA markers predicting benefit from adjuvant fluorouracil in patients with colon cancer: a molecular study. Lancet 360, 1381-1391, (2002).
    • (2002) Lancet , vol.360 , pp. 1381-1391
    • Barrat, P.L.1    Seymour, M.T.2    Stenning, S.P.3
  • 11
    • 33646151165 scopus 로고    scopus 로고
    • Genetic profiling of Stage I and II colorectal cancer may predict metastatic relapse
    • Al-Mulla F, Behbehani AI, Bitar MS, Varadharaj G, Going JJ: Genetic profiling of Stage I and II colorectal cancer may predict metastatic relapse. Mod. Pathol. 19, 648-658, (2006).
    • (2006) Mod. Pathol. , vol.19 , pp. 648-658
    • Al-Mulla, F.1    Behbehani, A.I.2    Bitar, M.S.3    Varadharaj, G.4    Going, J.J.5
  • 12
    • 0032585232 scopus 로고    scopus 로고
    • Randomised trial of irinotecan plus supportive care versus supportive care alone after fluorouracil failure for patients with metastatic colorectal cancer
    • Cunningham D, Pyrhonen S, James RD et al.: Randomised trial of irinotecan plus supportive care versus supportive care alone after fluorouracil failure for patients with metastatic colorectal cancer. Lancet 352, 1413-1418 (1998).
    • (1998) Lancet , vol.352 , pp. 1413-1418
    • Cunningham, D.1    Pyrhonen, S.2    James, R.D.3
  • 13
    • 0032585197 scopus 로고    scopus 로고
    • Randomised trial of irinotecan versus flourouracil by continouus infusion after fluorouracil failure in patients with metastatic colorectal cancer
    • Rougier P, Van Custem E, Bejetta E et al.: Randomised trial of irinotecan versus flourouracil by continouus infusion after fluorouracil failure in patients with metastatic colorectal cancer. Lancet 352, 1407-1412 (1998).
    • (1998) Lancet , vol.352 , pp. 1407-1412
    • Rougier, P.1    Van Custem, E.2    Bejetta, E.3
  • 14
    • 0034727063 scopus 로고    scopus 로고
    • Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer
    • Irinotecan Study Group
    • Saitz LB, Cox JV, Bianke C et al.: Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. Irinotecan Study Group. N. Engl. J. Med. 343, 905-914 (2000).
    • (2000) N. Engl. J. Med. , vol.343 , pp. 905-914
    • Saitz, L.B.1    Cox, J.V.2    Bianke, C.3
  • 15
    • 0034712536 scopus 로고    scopus 로고
    • Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: A multicentre randomized trial
    • Douillard JY, Cunningham D, Roth AD et al.: Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomized trial. Lancet 355, 1041-1047 (2000).
    • (2000) Lancet , vol.355 , pp. 1041-1047
    • Douillard, J.Y.1    Cunningham, D.2    Roth, A.D.3
  • 16
    • 0035884212 scopus 로고    scopus 로고
    • Mortality associated with irinotecan plus fluorouracil/leucovorin: Summary findings of an independent panel
    • Rothenberg ML, Meropol NJ, Poplin EA et al.: Mortality associated with irinotecan plus fluorouracil/leucovorin: summary findings of an independent panel. J. Clin. Oncol. 19, 3801-3807 (2001).
    • (2001) J. Clin. Oncol. , vol.19 , pp. 3801-3807
    • Rothenberg, M.L.1    Meropol, N.J.2    Poplin, E.A.3
  • 17
    • 1542675470 scopus 로고    scopus 로고
    • Improving the toxicity of irinotecan/5-FU/leucovorin: A 21-day schedule
    • Hwang JJ, Eisenberg SG, Marshall JL: Improving the toxicity of irinotecan/5-FU/leucovorin: a 21-day schedule. Oncology 17(Suppl. 8), 37-43 (2003).
    • (2003) Oncology , vol.17 , Issue.SUPPL. 8 , pp. 37-43
    • Hwang, J.J.1    Eisenberg, S.G.2    Marshall, J.L.3
  • 18
    • 0344783805 scopus 로고    scopus 로고
    • Phase II trial of oxaliplatin as first-line chemotherapy in metastatic colorectal cancer patients
    • Becouarn Y, Ychou M, Ducreux M et al.: Phase II trial of oxaliplatin as first-line chemotherapy in metastatic colorectal cancer patients. J. Clin. Oncol. 16, 2739-2744 (1998).
    • (1998) J. Clin. Oncol. , vol.16 , pp. 2739-2744
    • Becouarn, Y.1    Ychou, M.2    Ducreux, M.3
  • 19
    • 0004700371 scopus 로고    scopus 로고
    • Oxaliplatin as single agent in previously untreated colorectal carcinoma patients: A Phase II multicentric study
    • Diaz-Rubio E, Sastre J, Zaniboni A et al.: Oxaliplatin as single agent in previously untreated colorectal carcinoma patients: a Phase II multicentric study. Ann. Oncol. 9, 105-108 (1998).
    • (1998) Ann. Oncol. , vol.9 , pp. 105-108
    • Diaz-Rubio, E.1    Sastre, J.2    Zaniboni, A.3
  • 20
    • 0033874892 scopus 로고    scopus 로고
    • Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer
    • de Gramont A, Figer A, Seymour M et al.: Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer. J. Clin. Oncol. 18, 2938-2947 (2000).
    • (2000) J. Clin. Oncol. , vol.18 , pp. 2938-2947
    • de Gramont, A.1    Figer, A.2    Seymour, M.3
  • 21
    • 0033989203 scopus 로고    scopus 로고
    • Phase III muticenter randomized trial of oxaliplatin added to chronomodulated fluorouracil-leucovorin as first-line treatment of metastatic colorectal cancer
    • Giacchetti S, Perpoint B, Zidani R et al.: Phase III muticenter randomized trial of oxaliplatin added to chronomodulated fluorouracil-leucovorin as first-line treatment of metastatic colorectal cancer. J. Clin. Oncol. 18, 136-147 (2000).
    • (2000) J. Clin. Oncol. , vol.18 , pp. 136-147
    • Giacchetti, S.1    Perpoint, B.2    Zidani, R.3
  • 22
    • 0037531121 scopus 로고    scopus 로고
    • Superiority of oxaliplatin and fluorouracil-leucovorin compared with either therapy alone in patients with progressive colorectal cancer after irinotecan and fluorouracil-leucovorin: Interim results of a Phase III trial
    • Rothenberg ML, Oza AM, Bigelow RH et al: Superiority of oxaliplatin and fluorouracil-leucovorin compared with either therapy alone in patients with progressive colorectal cancer after irinotecan and fluorouracil-leucovorin: interim results of a Phase III trial. J. Clin. Oncol. 21, 2059-2069 (2003).
    • (2003) J. Clin. Oncol. , vol.21 , pp. 2059-2069
    • Rothenberg, M.L.1    Oza, A.M.2    Bigelow, R.H.3
  • 23
    • 0031019918 scopus 로고    scopus 로고
    • Randomized trial comparing monthly low-dose leucovorin and fluorouracil bolus with bimonthly high-dose leucovorin and fluorouracil bolus plus continuous infusion for advanced colorectal cancer: A French intergroup study
    • de Gramont A, Bosset JF, Milan C et al.: Randomized trial comparing monthly low-dose leucovorin and fluorouracil bolus with bimonthly high-dose leucovorin and fluorouracil bolus plus continuous infusion for advanced colorectal cancer: a French intergroup study. J. Clin. Oncol. 15, 808-815 (1997).
    • (1997) J. Clin. Oncol. , vol.15 , pp. 808-815
    • de Gramont, A.1    Bosset, J.F.2    Milan, C.3
  • 24
    • 0035018397 scopus 로고    scopus 로고
    • Five year survival following hepatic resection after neoadjuvant therapy for nonresectable colorectal liver metastases
    • Adam R, Avisar E, Ariche A et al.: Five year survival following hepatic resection after neoadjuvant therapy for nonresectable colorectal liver metastases. Ann. Surg. Oncol. 8, 347-353 (2000).
    • (2000) Ann. Surg. Oncol. , vol.8 , pp. 347-353
    • Adam, R.1    Avisar, E.2    Ariche, A.3
  • 25
    • 0035871538 scopus 로고    scopus 로고
    • Comparison of oral capecitabine versus intravenous fluorouracil plus leucovorin as first-line treatment in 605 patients with metastatic colorectal cancer: Results of a randomized Phase III study
    • Hoff PM, Ansari R, Batist G et al.: Comparison of oral capecitabine versus intravenous fluorouracil plus leucovorin as first-line treatment in 605 patients with metastatic colorectal cancer: results of a randomized Phase III study. J. Clin. Oncol. 19, 2282-2292 (2001).
    • (2001) J. Clin. Oncol. , vol.19 , pp. 2282-2292
    • Hoff, P.M.1    Ansari, R.2    Batist, G.3
  • 26
    • 0035503151 scopus 로고    scopus 로고
    • Oral capecitabine compared with intravenous fluorouracil plus leucovorin in patients with metastatic colorectal cancer: Results of a large Phase III study
    • van Cutsern E, Twelves C, Cassidy J et al.: Oral capecitabine compared with intravenous fluorouracil plus leucovorin in patients with metastatic colorectal cancer: Results of a large Phase III study. J. Clin. Oncol. 19, 4097-4106 (2001).
    • (2001) J. Clin. Oncol. , vol.19 , pp. 4097-4106
    • van Cutsern, E.1    Twelves, C.2    Cassidy, J.3
  • 27
    • 0036176033 scopus 로고    scopus 로고
    • Capecitabine as first-line treatment in colorectal cancer: Pooled data from two large, Phase III trials
    • Twelve C: Capecitabine as first-line treatment in colorectal cancer: pooled data from two large, Phase III trials. Eur. J. Cancer 38, 15-20 (2002).
    • (2002) Eur. J. Cancer , vol.38 , pp. 15-20
    • Twelve, C.1
  • 28
    • 1842569206 scopus 로고    scopus 로고
    • A randomized controlled trial of fluorouracil plus leocovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer
    • Goldberg RM, Sargent DJ, Morton RF et al.: A randomized controlled trial of fluorouracil plus leocovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer. J. Clin. Oncol. 22, 23-30 (2004).
    • (2004) J. Clin. Oncol. , vol.22 , pp. 23-30
    • Goldberg, R.M.1    Sargent, D.J.2    Morton, R.F.3
  • 29
    • 33645309877 scopus 로고    scopus 로고
    • FOLFOXIRI (folinic acid, 5-fluorouracil, oxaliplatin and ironotecan) vs FOLFIRI (folinic acid, 5-fluorouracil and irinotecan) as first-line treatment in metastatic colorectal cancer (MCC): A multicentre randomised Phase III trial from the Hellenic Oncology Research Group
    • Souglakos J, Androulakis N, Syrigos K et al.: FOLFOXIRI (folinic acid, 5-fluorouracil, oxaliplatin and ironotecan) vs FOLFIRI (folinic acid, 5-fluorouracil and irinotecan) as first-line treatment in metastatic colorectal cancer (MCC): a multicentre randomised Phase III trial from the Hellenic Oncology Research Group. Br. J. Cancer 94, 798-805 (2006).
    • (2006) Br. J. Cancer , vol.94 , pp. 798-805
    • Souglakos, J.1    Androulakis, N.2    Syrigos, K.3
  • 30
    • 1342290189 scopus 로고    scopus 로고
    • FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer: A randomized GERCOR study
    • Tournigand C, Andre T, Achille E et al.: FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer: a randomized GERCOR study. J. Clin. Oncol. 22, 229-237 (2004).
    • (2004) J. Clin. Oncol. , vol.22 , pp. 229-237
    • Tournigand, C.1    Andre, T.2    Achille, E.3
  • 31
    • 0042714530 scopus 로고    scopus 로고
    • Randomized Phase II trial of capecitabine plus irinotecan (CapIri) vs capecitabine plus oxaliplatin (CapOx) as first-line therapy of advanced colorectal cancer (ACRC)
    • Grothey A, Jordan K, Kellner O et al.: Randomized Phase II trial of capecitabine plus irinotecan (CapIri) vs capecitabine plus oxaliplatin (CapOx) as first-line therapy of advanced colorectal cancer (ACRC). Prog. Proc. Am. Soc. Clin. Oncol. 22, 255 (2003).
    • (2003) Prog. Proc. Am. Soc. Clin. Oncol. , vol.22 , pp. 255
    • Grothey, A.1    Jordan, K.2    Kellner, O.3
  • 32
    • 2142703727 scopus 로고    scopus 로고
    • Survival of patients with advanced colorectal cancer improves with the availability of fluorouracil-leucovorin, irinotecan, and oxaliplatin in the course of treatment
    • Grothey A, Sargent D, Goldberg RM et al.: Survival of patients with advanced colorectal cancer improves with the availability of fluorouracil-leucovorin, irinotecan, and oxaliplatin in the course of treatment. J. Clin. Oncol. 22, 1209-1214 (2004).
    • (2004) J. Clin. Oncol. , vol.22 , pp. 1209-1214
    • Grothey, A.1    Sargent, D.2    Goldberg, R.M.3
  • 33
    • 4444324751 scopus 로고    scopus 로고
    • Oxaliplatin reintroduction in patients previously treated with leucovorin, fluorouracil and oxaliplatin for metastatic colorectal cancer
    • Maindrault-Goebel F, Tournigand C, Andre T et al.: Oxaliplatin reintroduction in patients previously treated with leucovorin, fluorouracil and oxaliplatin for metastatic colorectal cancer. Ann. Oncol. 15, 1210-1214 (2004).
    • (2004) Ann. Oncol. , vol.15 , pp. 1210-1214
    • Maindrault-Goebel, F.1    Tournigand, C.2    Andre, T.3
  • 34
    • 9744230871 scopus 로고    scopus 로고
    • OPTIMOX study: FOLFOX7/LV5FU2 compared to FOLFOX 4 in patients with advanced colorectal cancer
    • de Gramont A, Cervantes A, Andre T et al.: OPTIMOX study: FOLFOX7/LV5FU2 compared to FOLFOX 4 in patients with advanced colorectal cancer. Proc. Am. Soc. Clin. Oncol. 22, 251 A3525 (2004).
    • (2004) Proc. Am. Soc. Clin. Oncol. , vol.22 , Issue.251
    • de Gramont, A.1    Cervantes, A.2    Andre, T.3
  • 35
    • 0043177668 scopus 로고    scopus 로고
    • Bevacizumab (a monoclonal antibody to vascular endothelial growth factor) prolongs survival in first-line colorectal cancer (CRC): Results of a Phase III trial of bevacizumab in combination with bolus IFL (irinotecan, 5-fluorouracil, leucovorin) as first-line therapy in subjects with metastatic CRC
    • Hurwitz H, Fehrenbacher L, Cartwright T et al.: Bevacizumab (a monoclonal antibody to vascular endothelial growth factor) prolongs survival in first-line colorectal cancer (CRC): results of a Phase III trial of bevacizumab in combination with bolus IFL (irinotecan, 5-fluorouracil, leucovorin) as first-line therapy in subjects with metastatic CRC. Proc. Am. Soc. Clin. Oncol. 22, A3646 (2003).
    • (2003) Proc. Am. Soc. Clin. Oncol. , vol.22
    • Hurwitz, H.1    Fehrenbacher, L.2    Cartwright, T.3
  • 36
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab (Avastin) plus irinotecan, 5-fluorouracil, and leucovorin for metastatic colorectal cancer
    • Hurwitz H, Fehrenbacher L Novotny W et al.: Bevacizumab (Avastin) plus irinotecan, 5-fluorouracil, and leucovorin for metastatic colorectal cancer. N. Eng. J. Med. 350, 2335-2342 (2004).
    • (2004) N. Eng. J. Med. , vol.350 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3
  • 37
    • 0037862765 scopus 로고    scopus 로고
    • Cetuximab (C225) alone or in combination with irinotecan (CPT-11) in patients with epidermal growth factor receptor (EGFR)-positive, irinotecan-refractory metastatic colorectal cancer (MCRC)
    • Cunningham D, Humblet Y, Siena S et al.: Cetuximab (C225) alone or in combination with irinotecan (CPT-11) in patients with epidermal growth factor receptor (EGFR)-positive, irinotecan-refractory metastatic colorectal cancer (MCRC). Proc. Am. Soc. Clin. Oncol. 22(252) A1012 (2003).
    • (2003) Proc. Am. Soc. Clin. Oncol. , vol.22 , Issue.252
    • Cunningham, D.1    Humblet, Y.2    Siena, S.3
  • 38
    • 3242720345 scopus 로고    scopus 로고
    • Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer
    • Cunningham D, Humblet Y, Siena S et al.: Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N. Eng. J. Med. 351, 337-345 (2004).
    • (2004) N. Eng. J. Med. , vol.351 , pp. 337-345
    • Cunningham, D.1    Humblet, Y.2    Siena, S.3
  • 39
    • 12944332507 scopus 로고    scopus 로고
    • Bevacizumab (Avastin), a monoclonal antibody to vascular endothelial growth factor, prolongs progression-free survival in first-line colorectal cancer in subjects who are not suitable for first-line CPT-11
    • Kabbinavar F, Schulz J, McCleod M et al.: Bevacizumab (Avastin), a monoclonal antibody to vascular endothelial growth factor, prolongs progression-free survival in first-line colorectal cancer in subjects who are not suitable for first-line CPT-11. J. Clin. Oncol. 22(Suppl.) 3516 (2004).
    • (2004) J. Clin. Oncol. , vol.22 , Issue.SUPPL. , pp. 3516
    • Kabbinavar, F.1    Schulz, J.2    McCleod, M.3
  • 40
    • 12944313265 scopus 로고    scopus 로고
    • High-dose bevacizumab in combination with FOLFOX4 improves survival in patients with previously treated advanced colorectal cancer: Results from Eastern Cooperative Group (ECOG) study E2300
    • American Society of Clinical Oncology, Orlando, FL, USA, May 13-17
    • Giantonio BJ, Catalano PJ, Meropol NJ et al.: High-dose bevacizumab in combination with FOLFOX4 improves survival in patients with previously treated advanced colorectal cancer: results from Eastern Cooperative Group (ECOG) study E2300. Proceeding of: the 2005 Gastrointestinal Cancers Symposium. American Society of Clinical Oncology, Orlando, FL, USA, May 13-17 (2005).
    • (2005) Proceeding Of: the 2005 Gastrointestinal Cancers Symposium
    • Giantonio, B.J.1    Catalano, P.J.2    Meropol, N.J.3
  • 41
    • 33645284166 scopus 로고    scopus 로고
    • Cetuximab and irinotecan as third-line therapy in advanced colorectal cancer patients: A single centre Phase II trial
    • Vincenzi B, Santini D, Rabitti C et al.: Cetuximab and irinotecan as third-line therapy in advanced colorectal cancer patients: a single centre Phase II trial. Br. J. Cancer 94, 792-797 (2006).
    • (2006) Br. J. Cancer , vol.94 , pp. 792-797
    • Vincenzi, B.1    Santini, D.2    Rabitti, C.3
  • 42
    • 7444222477 scopus 로고    scopus 로고
    • Expanded Phase I/II study of PTK787/ZK 222584 (PTK/ZK), a novel, oral angiogenesis inhibitor, in combination with FOLFOX-4 as first-line treatment for patients with metastatic colorectal cancer
    • Steward W, Thomas A, Morgan B et al.: Expanded Phase I/II study of PTK787/ZK 222584 (PTK/ZK), a novel, oral angiogenesis inhibitor, in combination with FOLFOX-4 as first-line treatment for patients with metastatic colorectal cancer. Proc. Am. Soc. Clin. Oncol. 22 (259) A2556 (2004).
    • (2004) Proc. Am. Soc. Clin. Oncol. , vol.22 , Issue.259
    • Steward, W.1    Thomas, A.2    Morgan, B.3
  • 43
    • 33646361363 scopus 로고    scopus 로고
    • Phase II study of capecitabine, oxaliplatin, and erlotinib in previously treated patients with metastastic colorectal cancer
    • Meyerhardt JA, Zhu AX, Enzinger PC et al.: Phase II study of capecitabine, oxaliplatin, and erlotinib in previously treated patients with metastastic colorectal cancer. J. Clin. Oncol. 24, 1892-1897 (2006).
    • (2006) J. Clin. Oncol. , vol.24 , pp. 1892-1897
    • Meyerhardt, J.A.1    Zhu, A.X.2    Enzinger, P.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.