Low but detectable serum levels of tacrolimus seen with the use of very dilute, extemporaneously compounded formulations of tacrolimus ointment in the treatment of patients with Netherton syndrome [2]

Archives of Dermatology

Volumn 142, Issue 10, 2006, Pages 1362-1363

  Shah, Kara N ^b   Yan, Albert C ^a  

^a CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CREATININE; ELECTROLYTE; TACROLIMUS; UREA;

BLOOD CELL COUNT; CASE REPORT; CHILD; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG FORMULATION; FEMALE; HUMAN; KIDNEY FUNCTION; LETTER; LIVER FUNCTION; NETHERTON DISEASE; PATIENT MONITORING; PRIORITY JOURNAL; TACHYPHYLAXIS; TREATMENT OUTCOME; UREA NITROGEN BLOOD LEVEL;

ADMINISTRATION, CUTANEOUS; CHEMISTRY, PHARMACEUTICAL; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; ICHTHYOSIFORM ERYTHRODERMA, CONGENITAL; IMMUNOSUPPRESSIVE AGENTS; OINTMENTS; TACROLIMUS;

EID: 33750044566     PISSN: 0003987X     EISSN: 0003987X     Source Type: Journal    
DOI: None     Document Type: Letter

References (8)

1. Chavanas S, Bodemer C, Rochat A, et al. Mutations in SPINK5, encoding a serine protease inhibitor, cause Netherton syndrome. Nat Genet. 2000;25:141-142.
2. Bens G, Boralevi F, Buzenet C, Taieb A. Topical treatment of Netherton's syndrome with tacrolimus ointment without significant systemic absorption. Br J Dermatol. 2003;149:224-226.
3. Oji V, Beljan G, Beier K, Traupe H, Luger TA. Topical pimecrolimus: a novel therapeutic option for Netherton syndrome. Br J Dermatol. 2005;153:1067-1068.
4. Boguniewicz M, Fiedler VC, Raimer S, et al; Pediatric Tacrolimus Study Group. A randomized, vehicle-controlled trial of tacrolimus ointment for treatment of atopic dermatitis in children. J Allergy Clin Immunol. 1998;102:637-644.
5. Alaiti S, Kang S, Fiedler VC, et al. Tacrolimus (FK506) ointment for atopic dermatitis: a phase I study in adults and children. J Am Acad Dermatol. 1998;38:69-76.
6. Hanifin JM, Ling MR, Langley R, Breneman D, Rafal E. Tacrolimus ointment for the treatment of atopic dermatitis in adult patients, 1: efficacy. J Am Acad Dermatol. 2001;44:S28-S38.
7. Allen A, Siegfried E, Silverman R, et al. Significant absorption of topical tacrolimus in 3 patients with Netherton syndrome. Arch Dermatol. 2001;137:747-750.
8. Allen DM, Esterly NB. Significant systemic absorption of tacrolimus after topical application in a patient with lamellar ichthyosis. Arch Dermatol. 2002;138:1259-1260.