Antigen-specific tolerance induced by IL-10 gene modified immature dendritic cells in experimental autoimmune myocarditis in rats

Chinese Medical Journal

Volumn 119, Issue 19, 2006, Pages 1646-1652

  Li, Wei Min ^a   Liu, Wei ^a   Gao, Cheng ^a   Zhou, Bao Guo ^a   Yang, Shu Sen ^a   Wang, Zheng ^a   Zhang, Rui Hong ^a   Gan, Run Tao ^a   Kong, Yi Hui ^a   Li, Yue ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

Dendritic cell; Experimental autoimmune myocarditis; Immunotherapy; Interleukin 10; Nuclear factor B

Indexed keywords

CARDIAC MYOSIN; DENDRITIC CELL VACCINE; DNA; EOSIN; FREUND ADJUVANT; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HEMATOXYLIN; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; LIPOPOLYSACCHARIDE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PHOSPHATE BUFFERED SALINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE DISEASE; BONE MARROW CELL; CELL ASSAY; CELL MATURATION; CELL STIMULATION; CELL SURFACE; CONTROLLED STUDY; CULTURE MEDIUM; DENDRITIC CELL; DISEASE SEVERITY; DNA MODIFICATION; DOWN REGULATION; FLOW CYTOMETRY; GENETIC TRANSFECTION; HISTOPATHOLOGY; IMMUNIZATION; IMMUNOLOGICAL TOLERANCE; LYMPHOCYTE PROLIFERATION; MALE; MYOCARDITIS; NONHUMAN; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN METABOLISM; RAT; T LYMPHOCYTE; UPREGULATION; WESTERN BLOTTING;

EID: 33750036665     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.1097/00029330-200610010-00009     Document Type: Article

References (20)

1. Liu W, Li WM, Sun NL. Polymorphism of the second exon of human leukocyte antigen-DQA1, -DQB1 gene and genetic susceptibility to idiopathic dilated cardiomyopathy in Hans of Northern China. Chin Med J 2005; 118: 238-241.
2. Luppi P, Rudert WA, Zanone MM, Stassi G, Trucco G, Finegold D, et al. Idiopathic dilated cardiomyopathy: a superantigen-driven autoimmune disease. Circulation 1998; 98: 777.
3. Yuan ZY, Liu Y, Liu Y, Zhang JJ, Kishimoto C, Wang YN, et al. PPAR-gamma ligands inhibit the expression of inflammatory cytokines and attenuate autoimmune myocarditis. Chin Med J 2004; 117: 1253-1255.
4. Li WM, Liu W, Gao C, Zhou BG. Immunoregulatory effects of atorvastatin on the experimental autoimmune myocarditis in Lewis rats. Immunol Cell Biol 2006; 84: 274-280.
5. Liu W, Gao C, Zhou BG, Li WM. Effects of adenovirus-mediated gene transfer of ICOS1g and CTLA41g fusion protein on experimental autoimmune myocarditis. Autoimmunity 2006; 39: 83-92.
6. Rescigno M, Martino M, Sutherland CL, Gold MR, Ricciardi-Castagnli P. Dendritic cell survival and maturation are regulated by different signaling pathways. J Exp Med 1998; 188: 2175-2180.
7. Bayry J, Thirion M, Delignat Misra N, Lacroix-Desmazes S, Kazatchkine MD, et al. Dendritic cells and autoimmunity. Autoimmun Rev 2004; 3: 183-187.
8. Figdor CG, de Vries IJ, Lesterhuis WJ, Melief CJ. Dendritic cell immunotherapy: mapping the way. Nat Med 2004; 10: 475-480.
9. Wallet MA, Sen P, Tisch R. Immunoregulation of dendritic cells. Clin Med Res 2005; 3: 166-175.
10. Li L, Elliott JF, Mosmann TR. IL-10 inhibits cytokine production, vascular leakage, and swelling during T helper 1 cell-induced delayed-type hypersensitivity. J Immunol 1994; 153: 3967-3978.
11. De Smedt T, Van Mechelen M, De Becker G, Urbain J, Leo O, Moser M. Effect of interleukin-10 on dendritic cell maturation and function. Eur J Immunol 1997; 27: 1229-1235.
12. Katsikis PD, Chu CQ, Brennan FM, Maini RN, Feldmann M. Immunoregulatory role of interleukin 10 in rheumatoid arthritis. J Exp Med 1994; 179: 1517.
13. Okura Y, Jee Y, Matsumoto Y. Acquired thymic tolerance to autoimmune encephalomyelitis is associated with activation of peripheral IL-10-producing macrophages/dendritic cells. Int Immunol 2003; 15: 437-446.
14. Inaba K, Inaba M, Romani N, Aya H, Deguchi M, Ikehara S, et al. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J Exp Med 1992; 176: 1693.
15. Hilliard BA, Mason N, Xu L, Sun J, Lamhamedi-Cherradi SE, Liou HC, et al. Critical roles of c-Rel in autoimmune inflammation and helper T cell differentiation. J Clin Invest 2002; 110: 843-850.
16. Liu W, Li WM, Gao C, Sun NL. Effects of atorvastatin on the Th1/Th2 polarization of ongoing experimental autoimmune myocarditis in Lewis rats. J Autoimmun 2005; 25: 258-263.
17. Verdijk RM, Mutis T, Esendam B, Kamp J, Melief Cee JM, Brand A et al. Polyriboinosinic polyribocytidylic acid (poly (I: C)) induces stable maturation of functionally active human dendritic cells. J Immunol 1999; 163: 57-61.
18. Li Q, Verma IM. NF-κB regulation in the immune system. Nat Rev 2002; 2: 725-734.
19. Ghosh S, May MJ, Kopp EB. NF-κB and Rel proteins: evolutionarily conserved mediators of immune responses. Annu Rev Immunol 1998; 16:225-260.
20. Molina-Holgado E, Arevalo-Martin A, Castrillo A, Bosca L, Vela JM, Guaza C. Interleukin-4 and interleukin-10 modulate nuclear factor κB activity and nitric oxide synthase-2 expression in Theiler's virus-infected brain astrocytes. J Neurochem 2002; 81: 1242-1252.