Molecular computational elements encode large populations of small objects

Nature Materials

Volumn 5, Issue 10, 2006, Pages 787-790

  De Silva, A Prasanna ^a   James, Mark R ^b   McKinney, Bernadine O F ^a   Pears, David A ^b   Weir, Sheenagh M ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^b Avecia Biologics Limited   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; DYES; FLUORESCENCE; LOGIC GATES; POLYMERS;

COMBINATORIAL CHEMISTRY; FLUORESCENCE SWITCHING; LOGIC SWITCHES; MOLECULAR COMPUTATIONAL ELEMENTS; MOLECULAR COMPUTATIONAL IDENTIFICATION (MCID);

MOLECULAR PHYSICS;

EID: 33750032374     PISSN: 14761122     EISSN: 14764660     Source Type: Journal    
DOI: 10.1038/nmat1733     Document Type: Article

References (32)

1. de Silva, A. P., Gunaratne, H. Q. N. & McCoy, C. P. A molecular photoionic AND gate based on fluorescent signalling. Nature 364, 42-44 (1993).
2. Adleman, L. M. Molecular computation of solutions to combinatorial problems. Science 266, 1021-1024 (1994).
3. Raymo, F. M. Digital processing and communication with molecular switches. Adv. Mater. 14, 401-414 (2002).
4. Balzani, V., Venturi, M. & Credi, A. Molecular Devices and Machines: A Journey into the Nanoworld (Wiley-VCH, Weinheim, 2003).
5. de Silva, A. P. & McClenaghan, N. D. Molecular-scale logic gates. Chem. Eur. J. 10, 574-586 (2004).
6. Szacilowski, K. Molecular logic gates based on pentacyanoferrate complexes: From simple gates to three-dimensional logic systems. Chem. Eur. J. 10, 2520-2528 (2004).
7. Margulies, D., Melman, G. & Shanzer, A. A molecular full-adder and full-subtractor, an additional step toward a moleculator. J. Am. Chem. Soc. 128, 4865-4871 (2006).
8. Stojanovic, M. N. & Stefanovic, D. A deoxyribozyme-based molecular automaton. Nature Biotechnol. 21, 1069-1074 (2003).
9. Uchiyama, S., McClean, G. D., Iwai, K. & de Silva, A. F. Membrane media create small nanospaces for molecular computation. J. Am. Chem. Soc. 127, 8920-8921 (2005).
10. Lam, K. S. et al. A new type of synthetic peptide library for identifying ligand-binding activity. Nature 354, 82-84 (1991).
11. Furka, A., Sebestyen, F., Asgedom, M. & Dibo, G. General-method for rapid synthesis of multicomponent peptide mixtures. Int. J. Pept. Prot. Res. 37, 487-493 (1991).
12. Queen's University of Belfast. Labelled solid support comprising fluorophore label. British patent 0506480.3 (2005).
13. de Silva, A. F. et al. Signaling recognition events with fluorescent sensors and switches. Chem. Rev. 97, 1515-1566 (1997).
14. www.osmetech.com.
15. Brummel, C. L., Lee, I. N. W., Zhou, Y., Benkovic, S. J. & Winograd, N. A. mass spectrometric solution to the address problem of combinatorial libraries. Science 264, 399-402 (1994).
16. Ohlmeyer, M. H. J. et al. Complex synthetic chemical libraries indexed with molecular tags. Proc. Natl Acad. Sci. USA 90, 10922-10926 (1993).
17. Bioarray Solutions & Rutgers, The State University of New Jersey. Colour-encoding and in-situ interrogation of matrix-coupled chemical compounds. World patent WO 98/53093 (1998).
18. Smith Kline Beecham Corp., Method of encoding a series of combinatorial libraries and developing structure-activity relationships. US patent 6,210,900 B1 (2001).
19. Egner, B. J. et al. Tagging in combinatorial chemistry: The use of coloured and fluorescent beads. Chem. Commun. 735-736 (1997).
20. Scott, R. H. & Balasubramaniam, S. Properties of fluorophores on solid phase resins; implications for screening, encoding and reaction monitoring. Bioorg. Med. Chem. Lett. 7, 1567-1572 (1997).
21. Walt, D. L. Bead-based fiber-optic arrays. Science 287, 451-452 (2000).
22. Battersby, B. J., Lawrie, G. A., Johnston, A. P. R. & Trau, M. Optical barcoding of colloidal suspensions: applications in genomics, proteomics and drug discovery. Chem. Commun. 1435-1441 (2002).
23. Dickinson, T. A., Michael, K. L., Kauer, J. S. & Walt, D. R. Convergent, self-encoded bead sensor arrays in the design of an artificial nose. Anal. Chem. 71, 2192-2198 (1999).
24. Lavigne, J. J. et al. Solution-based analysis of multiple analytes by a sensor array: Toward the development of an "electronic tongue". J. Am. Chem. Soc. 120, 6429-6430 (1998).
25. Nicolaou, K. C., Xiao, X. Y., Parandoosh, Z., Senyei, A. & Nova, M. Radiofrequency encoded combinatorial chemistry. Angew. Chem. Int. Edn 34, 2289-2291 (1995).
26. Moran, E. J. et al. Radiofrequency tag encoded combinatorial library method for discovery of tripeptide-substituted cinnamic acid of the protein tyrosine phosphatase. J. Am. Chem. Soc. 117, 10787-10788 (1995).
27. Millman, J. & Grabel, A. Microelectronics (McGraw-Hill, London, 1988).
28. Collier, C. P. et al. Electronically configurable molecular-based logic gates. Science 285, 391-394 (1999).
29. Copeland, G. T. & Miller, S. J. A chemosensor-based approach to catalyst discovery in solution and on solid support. J. Am. Chem. Soc. 121, 4306-4307 (1999).
30. Hayes, B. Am. Scientist 89, 490-494 (2001).
31. Jin, N. et al. Tri-state logic using vertically integrated Si-SiGe resonant interband tunneling diodes with double NDR Electron Devices Lett. 25, 646-648 (2004).
32. Keyes, R W. Physics of digital devices. Rev. Mod. Phys. 61, 279-287 (1989).