Structure-guided design of a novel class of benzyl-sulfonate inhibitors for influenza virus neuraminidase

Biochemical Journal

Volumn 399, Issue 2, 2006, Pages 215-223

  Platis, Dimitris ^a   Smith, Brian J ^b   Huyton, Trevor ^b   Labrou, Nikolaos E ^a  

^a AGRICULTURAL UNIVERSITY OF ATHENS   (Greece)

^b WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

Benzyl sulfonate inhibitor; Cibacron Blue 3GA (CB3GA); Influenza; Neuraminidase (NA); Structure guided design

Indexed keywords

BENZYL-SULFONATE INHIBITORS; CIBACRON BLUE 3GA (CB3GA); INFLUENZA; NEURAMINIDASE (NA); STRUCTURE-GUIDED DESIGN;

COMPLEXATION; DYES; ENZYMES; VIRUSES; X RAY ANALYSIS;

ENZYME INHIBITION;

1 AMINO 4 [(4 AMINO 3 SULFOPHENYL)AMINO] 9,10 DIOXO 4A,9,9A,10 TETRAHYDROANTHRACENE 2 SULFONIC ACID; 1 AMINO 4 [3 (4,6 DICHLOROTRIAZIN 2 YLAMINO) 4 SULFOPHENYLAMINO]ANTHRAQUINONE 2 SULFONIC ACID; 1 AMINO 4 BROMO 9,10 DIOXO 4A,9,9A,10 TETRAHYDROANTHRACENE 2 SULFONIC ACID; 2 [[4 CHLORO 6 [(2 SULFOPHENYL)AMINO] 1,3,5 TRIAZIN 2 YL]AMINO]BENZENESULFONIC ACID; 3 [(4 ANILINO 6 CHLORO 1,3,5 TRIAZIN 2 YL)AMINO]BENZENESULFONIC ACID; 3 [[4 CHLORO 6 [(3 SULFINOPHENYL)AMINO] 1,3,5 TRIAZIN 2 YL]AMINO]BENZENESULFONIC ACID; 4 [[4 CHLORO 6 [(4 SULFINOPHENYL)AMINO] 1,3,5 TRIAZIN 2 YL]AMINO]BENZENESULFONIC ACID; 6 CHLORO N,N' DIPHENYL 1,3,5 TRIAZINE 2,4 DIAMINE; AZIDE; CIBACRON BLUE F3GA; SIALIDASE; SIALIDASE INHIBITOR; SULFATE; SULFONIC ACID DERIVATIVE; TRIAZINE; UNCLASSIFIED DRUG;

AFFINITY LABELING; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; DRUG INHIBITION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME BINDING; ENZYME INHIBITION; INFLUENZA VIRUS; MOLECULAR MODEL; NONHUMAN; PHOTOAFFINITY LABELING; PRIORITY JOURNAL; SPECTROSCOPY; X RAY ANALYSIS;

ALKANESULFONATES; AMINO ACID SEQUENCE; BINDING SITES; DRUG DESIGN; KINETICS; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NEURAMINIDASE; ORTHOMYXOVIRIDAE; PHOTOAFFINITY LABELS; PROTEIN INTERACTION MAPPING; SEQUENCE ALIGNMENT; SPECTRUM ANALYSIS; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZINES;

ORTHOMYXOVIRIDAE;

EID: 33749999559     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20060447     Document Type: Article

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