Chlamydophila (Chlamydia) pneumoniae infection of human astrocytes and microglia in culture displays an active, rather than a persistent, phenotype

American Journal of the Medical Sciences

Volumn 332, Issue 4, 2006, Pages 168-174

  Dreses Werringloer, Ute ^b   Gérard, Hervé C ^a   Whittum Hudson, Judith A ^a   Hudson, Alan P ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b LONG ISLAND JEWISH MEDICAL CENTER   (United States)

Author keywords

Active infection; Alzheimer disease; Chlamydia pneumoniae; Pathogenesis

Indexed keywords

MESSENGER RNA;

ALZHEIMER DISEASE; ARTICLE; ASTROCYTE; BACTERIAL CHROMOSOME; BACTERIAL GENE; BACTERIAL GROWTH; BACTERIAL STRAIN; BACTERIUM IDENTIFICATION; CELL CYCLE ARREST; CELL DESTRUCTION; CELL STRUCTURE; CELL TYPE; CHLAMYDIA; CHLAMYDOPHILA PNEUMONIAE; CHROMOSOME ANALYSIS; CONTROLLED STUDY; CYTOLYSIS; DNA DETERMINATION; FTSK GENE; GENE EXPRESSION; HEP 2 CELL; HOST CELL; HUMAN; HUMAN CELL; MICROGLIA; NONHUMAN; PERSISTENT INFECTION; PHENOTYPE; PYK GENE; REAL TIME POLYMERASE CHAIN REACTION; RNA ANALYSIS; STANDARD;

ASTROCYTES; BACTERIAL PROTEINS; CELL CYCLE; CELL LINE, TUMOR; CHLAMYDOPHILA INFECTIONS; CHLAMYDOPHILA PNEUMONIAE; GENE EXPRESSION REGULATION, BACTERIAL; GENES, BACTERIAL; HUMANS; MICROGLIA; ORGAN SPECIFICITY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, BACTERIAL; RNA, MESSENGER; VIRULENCE;

EID: 33749864357     PISSN: 00029629     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000441-200610000-00003     Document Type: Article

References (32)

1. Hahn DL, Dodge RW, Golubjatnikov R. Association of Chlamydia pneumoniae (strain TWAR) infection with wheezing, asthmatic bronchitis, adult-onset asthma. J Am Med Assn 1991;266:225-30.
2. Grayston JT. Chlamydia pneumoniae, strain TWAR pneumonia. Annu Rev Med 1992;43:317-23.
3. Campbell LA, Kuo CC. Chlamydia pneumoniae pathogenesis. J Med Microbiol 2002;51:623-5.
4. Clementsen P, Permin H, Norn S. Chlamydia pneumoniae infection and its role in asthma and chronic obstructive pulmonary disease. J Investigat Allergol Clin Immunol 2002;12:73-9.
5. Leinonen M. Pathogenetic mechanisms and epidemiology of Chlamydia pneumoniae. Eur Heart J 1993;14:57-61.
6. Schumacher HR, Gérard HC, Arayssi TK, et al. Lower prevalence of Chlamydia pneumoniae DNA compared with Chlamydia trachomatis DNA in synovial tissue of arthritis patients. Arthritis Rheum 1999;42:1889-93.
7. Belland RJ, Ouellette SP, Gieffers J, et al. Chlamydia pneumoniae and atherosclerosis. Cell Microbiol 2004;6:117-27.
8. Kuo CC, Lee A, Campbell LA. Cleavage of the N-linked oligosaccharide from the surface of Chlamydia species affects attachment and infectivity of the organisms in epithelial and endothelial cells. Infect Immun 2004;72:6699-701.
9. Hatch TP. Developmental biology. In: Stephens RS, editor. Chlamydia - Intracellular biology, Pathogenesis, and Immunity. Washington DC: ASM Press, 1999. p. 29-67.
10. Byrne GI, Ouellette SP, Wang Z, et al. Chlamydia pneumoniae expresses genes required for DNA replication but not cytokinesis during persistent infection of HEp-2 cells. Infect Immun 2001;69:5423-9.
11. Gérard HC, Krauße-Opatz B, Rudy D, et al. Expression of Chlamydia trachomatis genes required for DNA synthesis and cell division in active vs. persistent infection. Mol Microbiol 2001;41:731-41.
12. Gérard HC, Freise J, Rudy D, et al. Chlamydia trachomatis genes whose products are related to energy metabolism are expressed differentially in active vs persistent infection. Microb Infect 2002;4:13-22.
13. Gérard HC, Whittum-Hudson JA, Schumacher HR, et al. Differential expression of the three Chlamydia trachomatis hsp60-encoding genes in active vs persistent infection. Microb Pathogen 2004;36:35-9.
14. Villareal C, Whittum-Hudson JA, Hudson AP. Persistent Chlamydiae and chronic arthritis. Arthritis Res 2002;4:5-9.
15. Hogan RJ, Mathews SA, Mukhopadhyay S, et al. Chlamydial persistence: beyond the biphasic paradigm. Infect Immun 2004;72:1843-55.
16. Koskiniemi M, Gencay M, Salonen O, et al. Chlamydia pneumoniae associated with central nervous system infections. Eur Neurol 1996;36:160-3.
17. Sriram S, Stratton CW, Yao S, et al. Chlamydia pneumoniae infection of the central nervous system in multiple sclerosis. Ann Neurol 1999;46:6-14.
18. Balin BJ, Gérard HC, Arking EJ, et al. Identification and localization of Chlamydia pneumoniae in the Alzheimer's brain. Med Microbiol Immunol 1998;187:23-42.
19. Clark CM, Karlawish JH. Alzheimer's disease: current concepts and emerging diagnostic and therapeutic strategies. Ann Intern Med 2003;138:400-10.
20. Lytle RA, Jiang Z, Zheng X, et al. Retinamide-induced apoptosis in glioblastomas is associated with down-regulation of Bcl-xL and Bcl-2 proteins. Neurooncol 2005;74:225-32.
21. de Gannes FM, Leducq N, Diolez P, et al. Mitochondrial impairment and recovery after heat shock treatment in a human microglial cell line. Neurochem Int 2000;36:233-41.
22. Gerard HC, Wildt KL, Whittum-Hudson JA, et al. The load of Chlamydia pneumoniae in the Alzheimer's brain varies with APOE genotype. Microb Pathogen 2005;39:19-26.
23. Myhre EB, Mårdh P-A. Chlamydia trachomatis infection in a patient with meningoencephalitis. N Engl J Med 1978;304:910-1.
24. Levitt D, Danen R, Levitt P. Selective infection of astocytes by Chlamydia trachomatis in primary mixed neuron-glial cell cultures. Infect Immun 1986;54:913-6.
25. Gérard HC, Wildt KL, Dreses-Werringloer U, et al. Chlamydia pneumoniae as a potential etiologic agent in sporadic Alzheimer's disease. In: Neuropsychiatric Disorders and Infection. Fatemi SH, ed. London, UK: Taylor and Francis Medical Books, 2005, p 229-38.
26. Gérard HC, Dreses-Werringloer U, Wildt K, et al. Chlamydophila (Chlamydia) pneumoniae in the Alzheimer's brain. FEHS Immunol Med Microbiol 2006, in press.
27. Boelen E, Steinbusch HWM, van der Ven AJAM, et al. Chlamydia pneumoniae infection of brain cells: an in vitro study. Neurobiol Aging 2006; in press (available as an e-pub ahead of print).
28. Airenne S, Surcel HM, Alakarppa H, et al. Chlamydia pneumoniae infection in human monocytes. Infect Immun 1999;67:1445-9.
29. Vilhardt F. Microglia: phagocyte and glia cell. Int J Biochem Cell Biol 2005;37:17-21.
30. Uruma T, Yamaguchi H, Fukuda M, et al. Chlamydia pneumoniae growth inhibition in human monocytic THP-1 cells and human epithelial HEp-2 cells by a novel phenoxazine derivative. J Med Microbiol 2005;54:1143-9.
31. Wittkop U, Krausse-Opatz B, Gust TC, et al. Fate of Chlamydophila pneumoniae in human monocyte-derived dendritic cells: long lasting low productive infection. Microb Pathogen 2006;40:101-9.
32. Gaydos CA, Summersgill JT, Sahney HH, et al. Replication of Chlamydia pneumoniae in vitro in human macrophages, endothelial cells, and aortic artery smooth muscle cells. Infect Immun 1996;64:1614-20.