SCOPUS 정보 검색 플랫폼

Volumn 34, Issue 20, 1995, Pages 2280-2282

Optimization of the Biological Activity of Combinatorial Compound Libraries by a Genetic Algorithm

Author keywords

combinatorial chemistry; compound libraries; enzyme inhibitors; genetic algorithm; multicomponent reactions

Indexed keywords

EID: 33749842822 PISSN: 05700833 EISSN: 15213773 Source Type: Journal
DOI: 10.1002/anie.199522801 Document Type: Article

Times cited : (190)

References (13)

3
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- Design neuartiger, nichtpeptidischer Thrombin-Inhibitoren und Struktur eines Thrombin-Inhibitor-Komplexes
- (1995) Angewandte Chemie , vol.107 , pp. 1874-1877
- Obst, U.¹ Gramlich, V.² Diederich, F.³ Weber, L.⁴ Banner, D.W.⁵

5
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- B. M. Trost, I. Fleming, C. H. Heathcock, Pergamon Press, Oxford
- (1991) Comprehensive organic synthesis: Selectivity for synthetic efficienty , vol.2 , pp. 1083-1109
- Ugi, I.¹ Lohberger, S.² Karl, R.³

8
- 0029275225
- Evolutionary Design of Molecules with Desired Properties Using the Genetic Algorithm
- 188–195.
- (1995) Journal of Chemical Information and Modeling , vol.35
- Venkatãsubramanian, V.¹ Chan, K.² Caruthers, J.M.³

10
- 84985497682
- In an alternative approach, biostructural information like the three‐dimensional structure of the target protein [5] may be used to limit the compound library at all substituents.

11
- 0020378102
- (chromogenic substrate S‐2238)
- (1982) Thromb. Res. , vol.28 , pp. 313
- Lottenberg, R.¹ Hall, J.A.² Fenton, J.W.³ Jackson, G.M.⁴

12
- 84985621973
- Product 6 is formed in the presence of water which either replaces the acid as the fourth component or by its reaction with the imino ester precursor of 5.

13
- 84985557386
- A daylight database, Daylight Chemical Information Systems, Inc., Irvine, CA, was used on a Silicon Graphics Onyx computer for storing chemical structures and biological activities. A C‐program for the genetic algorithm was written which uses this database.

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.