Characterization of a high-throughput screening assay for inhibitors of elongation factor P and ribosomal peptidyl transferase activity

Journal of Biomolecular Screening

Volumn 11, Issue 7, 2006, Pages 736-742

  Swaney, Steven ^a   McCroskey, Mark ^b   Shinabarger, Dean ^a,e   Wang, Zhigang ^c   Turner, Benjamin A ^d   Parker, Christian N ^d,f  

^a Biology i   (United States)

^b Global Technology   (United States)

^c Global Enzymology and Kinetics   (United States)

^d PFIZER INC   (United States)

^e Micromyx   (United States)

^f NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Elongation Factor P; High throughput screening; Protein synthesis

Indexed keywords

CHLORAMPHENICOL; ELONGATION FACTOR; ELONGATION FACTOR P; ELONGATION FACTOR P INHIBITOR; FORMYLMETHIONINE; FUSIDIC ACID; LINCOMYCIN; PEPTIDYLTRANSFERASE; PUROMYCIN; SPIRAMYCIN; STREPTOMYCIN; TETRACYCLINE; THIOSTREPTON; UNCLASSIFIED DRUG;

AMINO ACID ANALYSIS; ARTICLE; ENZYME ACTIVITY; ESCHERICHIA COLI; HIGH THROUGHPUT SCREENING; ISOTOPE LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN PURIFICATION; PROTEIN SYNTHESIS; RIBOSOME; RNA TRANSLATION; STAPHYLOCOCCUS AUREUS;

ANTI-BACTERIAL AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; ESCHERICHIA COLI; KINETICS; MICROBIAL SENSITIVITY TESTS; PEPTIDE ELONGATION FACTORS; PEPTIDYL TRANSFERASES; REPRODUCIBILITY OF RESULTS; RIBOSOMAL PROTEINS; RIBOSOMES; STAPHYLOCOCCUS AUREUS; TIME FACTORS;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; STAPHYLOCOCCUS AUREUS;

EID: 33749827782     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057106291634     Document Type: Article

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