No association of single nucleotide polymorphisms in the μ-opioid receptor subunit gene with idiopathic generalized epilepsy

Epilepsia

Volumn 47, Issue 10, 2006, Pages 1728-1731

  Barratt, Catherine ^a   Lai, Teck ^a   Nashef, Lina ^b   Valentin, Antonio ^b   Fisniku, Leonora ^b   Moran, Nicholas ^b,c   Asherson, Philip ^a   Makoff, Andrew ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b KING S COLLEGE HOSPITAL   (United Kingdom)

^c KENT AND CANTERBURY HOSPITAL   (United Kingdom)

Author keywords

Association study; Haplotype; IGE; Linkage disequilibrium; OPRM1

Indexed keywords

DNA; MU OPIATE RECEPTOR;

5' UNTRANSLATED REGION; ABSENCE; ARTICLE; CONTROLLED STUDY; ELECTROENCEPHALOGRAM; FEMALE; GENE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENE MUTATION; GENERALIZED EPILEPSY; GENOTYPE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MAJOR CLINICAL STUDY; MALE; MYOCLONUS EPILEPSY; OPRM1 GENE; PHOTOSENSITIVITY; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SINGLE NUCLEOTIDE POLYMORPHISM; TONIC CLONIC SEIZURE;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DNA MUTATIONAL ANALYSIS; EPILEPSY, ABSENCE; EPILEPSY, GENERALIZED; FEMALE; GENE FREQUENCY; GENETIC LINKAGE; GENOTYPE; HUMANS; LINKAGE (GENETICS); MALE; MUTATION; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, OPIOID, MU;

EID: 33749684456     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/j.1528-1167.2006.00844.x     Document Type: Article

References (12)

1. Arias A, Feinn R, Kranzler HR. (2006) Association of an Asn40Asp (A118G) polymorphism in the μ-opioid receptor gene with substance dependence: A meta-analysis. Drug Alcohol Depend. 83:262-268.
2. Beck-Mannagetta G, Janz D. (1991) Syndrome-related genetics in generalised epilepsy. Epilepsy Res Suppl 4:105-111.
3. Berkovic SF, Howell RA, Hay DA, Hopper JL. (1994) Epilepsies in twins. London: John Libbey, pp.157-164.
4. Berkovic SF, Howell RA, Hay DA, Hopper JL. (1998) Epilepsies in twins: genetics of the major epilepsy syndromes. Ann Neurol 43:435-445.
5. Bond C, LaForge KS, Tian M, Melia D, Zhang S, Borg L, Gong J, Schluger J, Strong JA, Leal SM, Tischfield JA, Kreek MJ, Yu L. (1998) Single-nucleotide polymorphism in the human μ-opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction. Proc Natl Acad Sci USA 95:9608-9613.
6. Hoehe MR, Kopke K, Wendel B, Rohde K, Flachmeier C, Kidd KK, Berrettini WH, Church GM. (2000) Sequence variability and candidate gene analysis in complex disease: association of μ-opioid receptor gene variation with substance dependence. Hum Mol Genet 9:2895-2908.
7. Ioannidis JP, Ntzani EE, Trikalinos TA, Contopoulos-Ioannidis DG. (2001) Replication validity of genetic association studies. Nat Genet 29:306-309.
8. Jang CG, Lee SY, Loh HH, Ho IK. (2001) Lack of μ-opioid receptor leads to an increase in the NMDA receptor subunit mRNA expression and NMDA-induced convulsion. Mol Brain Res 94:105-111.
9. Makoff A, Asherson P, Nashef L. (2005) Authors' Voluntary Retraction. Neurology 64:579.
10. Sander T, Berlin W, Gscheidel N, Wendel B, Janz D, Hoehe MR. (2000) Genetic variation of the human μ-opioid receptor and susceptibility to idiopathic absence epilepsy. Epilepsy Res 39:57-61.
11. Wilkie H, Osei-Lah A, Chioza B, Nashef L, McCormick D, Asherson P, Makoff AJ. (2002) Association of the μ-opioid receceptor subunit gene and idiopathic generalised epilepsy. Neurology 59:724-728.
12. Zhang Y, Wang D, Johnson AD, Papp AC, Sadee W. (2005) Allelic expression imbalance of human μ-opioid receptor (OPRM1) caused by variant A118G. J Biol Chem 280:32618-32624.