Comparison of the effects of imidapril and enalapril in a prospective, multicentric randomized trial in dogs with naturally acquired heart failure

Journal of Veterinary Cardiology

Volumn 6, Issue 2, 2004, Pages 9-16

  Amberger, Chris ^a   Chetboul, Valérie ^b   Bomassi, Eric ^c   Rougier, Sandrine ^d   Woehrlé, Frédérique ^d   Thoulon, Fabrice ^d  

^a Ecole Nationale Vétérinaire d'Alfort ^*  (Switzerland)

^b ECOLE NATIONALE VÉTÉRINAIRE D ALFORT   (France)

^c CLINIQUE VÉTÉRINAIRE   (France)

^d Vetoquinol Research Centre   (France)

Author keywords

Congestive heart failure; Dogs; Enalapril; Imidapril

Indexed keywords

DIGOXIN; ENALAPRIL; FUROSEMIDE; IMIDAPRIL;

ADD ON THERAPY; ARTICLE; ASCITES; CONGESTIVE CARDIOMYOPATHY; CONTROLLED STUDY; COUGHING; DISEASE CLASSIFICATION; DOG DISEASE; DRUG DOSE INCREASE; DRUG EFFICACY; DRUG RESPONSE; DRUG TOLERABILITY; DYSPNEA; EXERCISE TOLERANCE; FATIGUE; FEMALE; FOLLOW UP; HEART FAILURE; LUNG EDEMA; MALE; MONOTHERAPY; NONHUMAN; OUTCOMES RESEARCH; PRIORITY JOURNAL; QUALITY OF LIFE; SCORING SYSTEM; SUPRAVENTRICULAR TACHYCARDIA; SURVIVAL TIME; VALVULAR HEART DISEASE;

ANIMALIA; CANIS FAMILIARIS;

EID: 33749665435     PISSN: 17602734     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1760-2734(06)70053-4     Document Type: Article

References (16)

1. Blackford L., Golden L., Bright J., et al. Captopril provides sustained hemodynamic benefits in dogs with experimentally induced mitral regurgitation. Vet Surg 19 (1990) 237-242
2. Holtz J., Munzel T., Sommer O., et al. Converting enzyme inhibition by enalapril in experimental heart failure. Nephron 55 (1990) 73-76
3. Allworth M., Church D., Maddison J., et al. Effect of enalapril in dogs with pacing-induced heart failure. Am J Vet Res 56 (1995) 85-94
4. The IMPROVE Study Group. Acute and short-term hemodynamic, echocardiographic, and clinical effects of enalapril maleate in dogs with naturally acquired heart failure: results of the Invasive Multicenter PROspective Veterinary evaluation of Enapril study. J Vet Intern Med 9 (1995) 234-242
5. The COVE Study Group. Controlled clinical evaluation of enalapril in dogs with heart failure: Results of the Cooperative Veterinary Enalapril Study Group. J Vet Intern Med 9 (1995) 243-252
6. Hamlin R., Benitz A., Ericsson G., et al. Effects of enalapril on exercise tolerance and longevity in dogs with heart failure produced by iatrogenic mitral regurgitation. J Vet Intern Med 10 (1996) 85-87
7. Ettinger S., Benitz A., Ericsson G., et al., for the LIVE Study Group. Effects of enalapril maleate on survival of dogs with naturally acquired heart failure. J Am Vet Med Assoc 11 (1999) 1573-1577
8. The BENCH Study Group. The effect of Benazepril on survival times and clinical signs of dogs with congestive heart failure: Results of a multicenter, prospective, randomised, double-blinded, placebo-controlled, long term clinical trial. J Vet Cardiol 1 (1999) 7-18
9. Schneider M, Woehrlé F, Boisramé B. Pharmacokinetics of imidapril and its active metabolite in dogs. Proceedings of the BSAVA Congress 2002: 156.
10. Hamlin R., and Nakayama T. Comparison of some pharmacokinetic parameters of 5 angiotensin-converting enzyme inhibitors in normal beagles. J Vet Intern Med 12 (1998) 93-95
11. Yamada Y., Endo M., Kohno M., et al. Metabolic Fate of the new Angiotensin-Converting Enzyme Inhibitor Imidapril in Animals: Absorption, pharmacokinetics and excretion in rats and dogs. Drug Res 42 (1992) 457-465
12. Thoulon F. Tolerance of imidapril, a new angiotensin converting enzyme inhibitor in the dog. Proceedings of the FECAVA Congress 2001: 90.
13. Autran de Morais H. Pathophysiology of heart failure and clinical evaluation of cardiac function. In: Ettinger S., and Feldman E. (Eds). Textbook of veterinary internal medicine, diseases of the dog and cat. (2000), WB Saunders, Philadelphia 692-712
14. Dunnet C., and Gent M. Significance testing to establish equivalence between treatments, with special reference to data in the form of 2x2 tables. Biometrics 33 (1977) 593-602
15. Kvart C., Häggström J., Pedersen H., et al. Efficacy of enalapril for prevention of congestive heart failure in dogs with myxomatous valve disease and asymptomatic mitral regurgitation. J Vet Intern Med 16 (2002) 80-88
16. Atkins CE. Enalapril monotherapy in asymptomatic mitral regurgitation, results of Vetproof. Proceedings of the 20th ACVIM Forum 2002: 75-76.