Clonidine induced endothelium-dependent tonic contraction in circular muscle of the rat hepatic portal vein

Journal of Smooth Muscle Research

Volumn 42, Issue 2-3, 2006, Pages 63-74

  Shimamura, Keiichi ^a   Toba, Miyuki ^a   Kimura, Shinichi ^a   Ohashi, Atsuko ^a   Kitamura, Kenji ^b  

^a HEALTH SCIENCES UNIVERSITY OF HOKKAIDO   (Japan)

^b FUKUOKA DENTAL COLLEGE   (Japan)

Author keywords

Clonidine; Endothelium; Portal vein; Tonic contraction

Indexed keywords

1 [2 (4 METHOXYPHENYL) 2 [3 (4 METHOXYPHENYL)PROPOXY]ETHYL] 1H IMIDAZOLE; ALPHA 2 ADRENERGIC RECEPTOR; CATALASE; CATION CHANNEL; CLONIDINE; DICLOFENAC; N(G) NITROARGININE; NITRIC OXIDE; PROSTAGLANDIN SYNTHASE; SUPEROXIDE DISMUTASE; YOHIMBINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG INHIBITION; DRUG MECHANISM; ENDOTHELIUM; ENZYME INHIBITION; LIVER; MALE; MUSCLE ISOMETRIC CONTRACTION; MUSCLE RELAXATION; MUSCLE TWITCH; MYOTONIA; NONHUMAN; PORTAL VEIN; RAT; SMOOTH MUSCLE CONTRACTION; VASCULAR SMOOTH MUSCLE;

ADRENERGIC ALPHA-AGONISTS; ANIMALS; CLONIDINE; DICLOFENAC; ENDOTHELIUM, VASCULAR; HUMANS; HYPERTENSION, PORTAL; ISOMETRIC CONTRACTION; LIVER CIRRHOSIS; MALE; MUSCLE CONTRACTION; MUSCLE, SMOOTH, VASCULAR; NITRIC OXIDE; NITROARGININE; PORTAL VEIN; RATS; RATS, WISTAR;

EID: 33749656789     PISSN: 09168737     EISSN: 09168737     Source Type: Journal    
DOI: 10.1540/jsmr.42.63     Document Type: Article

References (34)

1. Angus, J.A., Cocks, T.M. and Satoh, K. (1986). The α-adrenoceptors on endothelial cells. Fed. Proc. 45: 2355-2359.
2. 2-adrenoceptor-mediated modulation of adenosine 5′ triphosphate and noradrenaline corelease: differences in canine mesenteric artery and vein. J. Auton. Pharmacol. 21: 47-55.
3. Esler, M., Dudley, F., Jennings, G., Debinski, H., Lambert, G., Jones, P., Crotty, B. Colman, J. and Willett, I. (1992). Increased sympathetic nervous activity and the effects of its inhibition with clonidine in alcoholic cirrhosis. Ann. Int. Med. 116: 446-455.
4. + channels. Br. J. Pharmacol. 131: 788-794.
5. Feletou, M., Hoeffner, U. and Vanhoutte, P.M. (1989). Endothelium-dependent relaxing factors do not affect the smooth muscle of portal-mesenteric vein. Blood Vessels 26: 21-32.
6. 2- adrenoceptor activation. Br. J. Pharmacol. 134: 957-968.
7. Fleig, W.E. (1988). Pharmacological methods for the prevention of the first and recurrent bleeding from esophageal varices. Z. Gastroenterol. 26 (Suppl. 2): 40-48.
8. Furchgott, R.F. and Zawadski, J.V. (1981). The obligatory role of the endothelial cells in the relaxation of arterial smooth muscle cells by acetylcholine. Nature 288: 373-376.
9. Furuta, T. (1988). Precontraction-induced contractile response of isolated canine portal vein to alpha-2 adrenoceptor agonists. Naunyn-Schmiedeberg's Arch. Pharmacol. 337: 525-530.
10. Henriksen, J.H., Ring-Larsen, H., Kanstrup, I.L. and Christensen, N.J. (1984). Splanchnic and renal elimination and release of catecholamines in cirrhosis. Evidence of enhanced nervous activity in patients with decompensated cirrhosis. Gut 25: 1034-1043.
11. Katusic, Z.S. and Vanhoutte, P.M. (1989). Superoxide anion is an endothelium-derived contracting factor. Am. J. Physiol. 257: H33-H37.
12. 2A-adrenoceptor subtypes stimulate voltage-operated L-type calcium channels in rat portal vein myocytes. Evidence for two distinct transduction pathways. J. Biol. Chem. 269: 29546-29552.
13. Lin, H.C., Soubrane, O. and Lebrec, D. (1991). Prevention of portal hypertension and postsystemic shunts by early chronic administration of clonidine in conscious portal vein-stenosed rats. Hepatol. 14: 325-330.
14. Lui, A.H., McManus, B.M. and Laher, I. (2000). Endothelial and myogenic regulation of coronary artery tone in the mouse. Eur. J. Pharmacol. 410: 25-31.
15. 2+ channels in rat portal vein myocytes. Pflügers Arch. 430: 590-592.
16. Martin, W., Furchgott, R.F., Villani, G.M. and Jothianandan, D. (1986). Depression of contractile responses in rat aorta by spontaneously released endothelium-derived relaxing factor. J. Pharmacol. Exp. Ther. 237: 529-538.
17. Mathison, R. (1983). Actions of neurotransmitters and peptides on longitudinal and circular muscle of the rat portal vein. J. Pharm. Pharmacol. 35: 34-37.
18. McGrath, J.C., Monaghan, S., Templeton, A.G.B. and Wilson, V.G. (1990). Effect of basal and acetylcholine-induced release of endothelium-derived relaxing factor on contraction to α-adrenoceptor agonists in a rabbit artery and corresponding veins. Br. J. Pharmacol. 99: 77-86.
19. Moreau, R., Lee, S.S., Hadengue, A., Braillan, A. and Lebrec, D. (1987). Hemodynamic effects of a clonidine-induced decrease in sympathetic tone in patients with cirrhosis. Hepatol. 7: 149-154.
20. Nishina, H., Ozaki, T., Hanso, M.A. and Poston, L. (1999). Mechanisms of noradrenaline-induced vasorelaxation in isolated femoral arteries of the neonatal rat. Br. J. Pharmacol. 127: 809-812.
21. Pearson, P.J. and Vanhoutte, P.M. (1993). Vasodilator and vasoconstrictor substances produced by the endothelium. Rev. Physiol. Biochem. Pharmacol. 122: 1-67.
22. Roulot, D., Braillon, A., Gaudin, C., Ozier, Y., Girod, C. and Lebrec, D. (1989). Mechanisms of a clonidine-induced decrease in portal pressure in normal and cirrhotic conscious rats. Hepatol. 10: 477-481.
23. 2-adrenoceptor-induced relaxations in the circular and longitudinal smooth muscle layers of the rat portal vein. Acta. Physiol. Scand. 130: 601-607.
24. Shimamura, K., Zou, L.-B., Matsuda, K., Sekiguchi, F., Yamamoto, K. and Sunano, S. (2000). Role of nitric oxide in the contraction of circular muscle in the rat portal vein. Pflügers Arch. 440: 435-439.
25. Shimamura, K., Zhou, M., Toba, M., Kimura, S., Higuchi, T., Kawaguchi, H., Sekiguchi, F. and Sunano, S. (2003). Effects of L-arginine on spontaneous contraction of the rat portal vein. Pflügers Arch. 446: 30-35.
26. Shoji, T., Tsuru, H. and Shigei, T. (1983). A regional differences in the distribution of post synaptic alpha adrenoceptor subtypes in canine veins. Naunyn-Schmiedeberg's Arch. Pharmacol. 324: 246-255.
27. Szatmari, V., van den Ingh, T.S., Fenyves, B., Sotonyi, P., Kotai, I., Petrasi, Z. and Voros, K. (2002). Portal hypertension in a dog due to circumscribed fibrosis of the wall of the extrahepatic portal vein. Vet. Rec. 150: 602-605.
28. 2-adrenoceptor-mediated endothelium-dependent vasodilation. Circ. Res. 82: 1323-1329.
29. Vedernikov, Y.P., Vihert, A.M. and Leisner, H. (1987). Arterial endothelium-derived relaxing factor (AEDRF) does not suppress papillary muscle or portal vein contractions. Eur. J. Pharmacol. 142: 471-474.
30. Willett, I.R., Esler, M., Jennings, G. and Dudley, F.J. (1986). Sympathetic tone modulates portal venous pressure in alcoholic cirrhosis. Lancet 2: 939-942.
31. Wing, L.M., Reid, J.L., Davies, D.S., Neill, F.A., Tippett, P. and Dollery, C.T. (1977). Pharmacokinetic and concentration-effect relationship of clonidine in essential hypertension. Eur. J. Clin. Pharmacol. 12: 463-469.
32. Yang, D., Feletou, M., Boulanger, C.M., Wu, H.F., Levens, N., Zhang, J.N. and Vanhoutte, P.M. (2002). Oxygen-derived free radicals mediate endothelium-dependent contraction to acetylcholine in aortas from spontaneously hypertensive rats. Br. J. Pharmacol. 136: 104-110.
33. Yang, D., Feletou, M., Levens, N., Zhang, J.N. and Vanhoutte, P.M. (2003). A diffusible substance(s) mediates endothelium-dependent contractions in the aorta of SHR. Hypertens. 41: 143-148.
34. Yomaida, I., Murao, M., Togashi, H., Shimamura, K., Koike, Y. and Saito, H. (1979). Effects of long-term administration and withdrawal of clonidine on activity of sympathetic efferent nerve unit in spontaneously hypertensive rats. Neurosci. Lett. 15: 249-251.