Induction of apoptosis by 25-hydroxycholesterol in adult rat Leydig cells: Protective effect of 17β-estradiol

Reproductive Toxicology

Volumn 22, Issue 4, 2006, Pages 564-570

  Travert, Carine ^a   Carreau, Serge ^a   Le Goff, Dominique ^a  

^a UNIVERSITÉ DE CAEN   (France)

Author keywords

17 Estradiol; Apoptosis; Caspase 3 inhibitor; Leydig cells; Oxysterol; Rat; Testosterone

Indexed keywords

25 HYDROXYCHOLESTEROL; ACETYLASPARTYLGLUTAMINYLVALYLASPARTYLCHOLINE; CASPASE 3 INHIBITOR; ESTRADIOL; OXYSTEROL; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; CELL DEATH; CELL LEVEL; CELL PROTECTION; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; CYTOTOXICITY; ESTROGEN ACTIVITY; HORMONAL REGULATION; HORMONE DETERMINATION; LEYDIG CELL; MALE; NICK END LABELING; NONHUMAN; RAT; REVIEW; STEROL METABOLISM; TESTOSTERONE SYNTHESIS;

3-HYDROXYSTEROID DEHYDROGENASES; ACETATES; ANIMALS; APOPTOSIS; CARBON RADIOISOTOPES; CASPASE 3; CELL SURVIVAL; CHORIONIC GONADOTROPIN; DNA FRAGMENTATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; ESTRADIOL; HYDROXYCHOLESTEROLS; IN SITU NICK-END LABELING; LEYDIG CELLS; MALE; OLIGOPEPTIDES; RATS; RATS, SPRAGUE-DAWLEY; TESTOSTERONE; TIME FACTORS;

EID: 33749643514     PISSN: 08906238     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.reprotox.2006.05.006     Document Type: Review

References (50)

1. Russel D. Oxysterol biosynthetic enzymes. Biochem Biophys Acta 1529 (2000) 126-135
2. Schroepfer G. Oxysterols: modulators of cholesterol metabolism and other processes. Physiol Rev 80 (2000) 361-554
3. Krut L., Yang J., Schonfeld G., and Ostlund R. The effects of oxidizing cholesterol on gastrointestinal absorption, plasma clearance, tissue distribution and processing by endothelial cells. Arterioscler Thromb Vasc Biol 17 (1997) 778-785
4. Babiker A., and Disczfaluzy U. Transport of side-chain oxidized oxysterols in the human circulation. Biochim Biophys Acta 1392 (1998) 333-339
5. Tamasawa N., Hayakari M., Murakami H., Matsui J., and Suda T. Reduction of oxysterol levels up-regulate HMG-CoA reductase activity in rat liver. Atherosclerosis 131 (1997) 237-242
6. Cheng D., Chang C.C.Y., Qu X.M., and Chang T.Y. Activation of acyl-coenzyme A: cholesterol acyltranferase by cholesterol or by oxysterol in a cell-free system. J Biol Chem 270 (1995) 685-695
7. Lizard G., Moisant M., Cordelet C., Monier S., Gambert P., and Lagros L. Induction of similar feature of apoptosis in human and bovine vascular endothelial cells treated by 7-ketocholesterol. J Pathol 183 (1997) 330-338
8. Maier G., Bing G., Falken U., Wagner E., and Unger C. Antitumor activity and induction of apoptosis by water-soluble derivatives of 7β-hydroxycholesterol in human colon carcinoma cell lines. Anticancer Res 19 (1999) 4251-4256
9. Kölsch H., Ludwig M., Lütjohann D., and Rao M.L. Neurotoxicity of 24-hydroxycholesterol, an important cholesterol elimination product of the brain, may be prevented by vitamin E and estradiol-17beta. J Neural Transm 108 (2001) 475-488
10. Le Goff D., Viville C., and Carreau S. Apoptotic effects of 25-hydroxycholesterol in immature rat Sertoli cells: prevention by 17β-estradiol. Reprod Toxicol 21 (2006) 329-334
11. Majno G., and Joris I. Apoptosis, oncosis, and necrosis. An overview of cell death. Am J Pathol 146 (1995) 3-15
12. Kim J.-M., Luo L., and Zirkin B.R. Caspase-3 activation is required for Leydig cell apoptosis induced by ethane dimethanesulfonate. Endocrinology 141 (2000) 1846-1853
13. Lukyanenko Y., Chen J.J., and Hutson J.C. Production of 25-hydroxycholesterol by testicular macrophages and its effects on Leydig cells. Biol Reprod 64 (2001) 790-796
14. Georgiou M., and Payne A.H. 25-Hydroxycholesterol-supported and 8-bromo-adenosine 3′,5′-monophosphate-stimulated testosterone production by primary cultures of two populations of rat Leydig cells. Endocrinology 117 (1985) 1184-1188
15. Ness W.D., Lukyanenko Y., Jia Z.H., Quideau S., Howald W.N., Pratum T.K., et al. Identification of the lipophilic factor produced by macrophages that stimulates steroidogenesis. Endocrinology 141 (2000) 953-958
16. Fisher J.S., Millar M.R., Saunders P.T., Fraser H.M., and Sharpe R.M. Immunolocalisation of oestrogen receptor-α within the testis and excurrent ducts of the rat and marmoset monkey from perinatal life to adulthood. J Endocrinol 153 (1997) 485-495
17. Saunders P.T.K., Fisher J.S., Sharpe R.M., and Millar M.R. Expression of oestrogen receptor beta (ERβ) occurs in multiple cell types, including some germ cells, in the rat testis. J Endocrinol 156 (1998) R13-R16
18. Carreau S. Estrogens-male hormones?. Folia Histochem Cytobiol 41 (2003) 107-111
19. Murdoch W.J. Inhibition by oestradiol of oxidative stress-induced apoptosis in pig ovarian tissues. J Reprod Fertil 114 (1998) 127-130
20. Bae Y.H., Hwang J.Y., Kim Y.H., and Koh J.K. Anti-oxidative neuroprotection by estrogens in mouse cortical cultures. J Korean Med Sci 15 (2000) 327-336
21. McMurray R.W., Wilson J.G., Bigler L., Xiang L., and Lagoo A. Progesterone inhibits glucocorticoid-induced murine thymocyte apoptosis. Int J Immunopharmacol 22 (2000) 955-965
22. Sudoh N., Toba K., Akishita M., et al. Estrogens prevents oxidative stress-induced endothelial cell apoptosis in rats. Circulation 103 (2001) 724-729
23. Monroe D.G., Berger R.R., and Sanders M. Tissue-protective effects of estrogen involve regulation of caspase gene expression. Mol Endocrinol 1 (2002) 1322-1331
24. Behl C. Estrogen can protect neurons: modes of action. J Steroid Biochem Mol Biol 83 (2003) 195-197
25. Yang R.-C., Shih H.-C., Hsu H.-K., Chang H.-C., and Hsu C. Estradiol enhances the neurotoxicity of glutamate in GT1-7 cells through an estrogen receptor-dependent mechanism. Neurotoxicology 24 (2003) 65-73
26. Papadopoulos V., Carreau S., and Drosdowsky M.A. Effects of phorbol ester and phospholipase C on LH-stimulated steroidogenesis in purified rat Leydig cells. FEBS Lett 188 (1985) 312-316
27. Aldred L.F., and Cooke B.A. The effect of cell damage on the density and steroidogenic capacity of rat Leydig cells, using an NADH exclusion test for determination of viability. J. Steroid Biochem 18 (1983) 411-414
28. DeLamatre J.G., Sarphie T.G., Archibold R.C., and Hornick C.A. Metabolism of apo E-free high density lipoproteins in rat hepatoma cells: evidence for a retroendocytic pathway. J Lipid Res 31 (1990) 191-202
29. Hara A., and Radin N.S. Lipid extraction of tissues with a low-toxicity solvent. Anal Biochem 90 (1978) 420-426
30. Gavrieli Y., Sherman Y., and Ben-Sasson S.A. Identification of programmed cell death in situ via specific labelling of nuclear DNA fragmentation. J Cell Biol 119 (1992) 493-501
31. Genissel C., and Carreau S. Regulation of the aromatase gene expression in mature rat Leydig cells. Mol Cell Endo 178 (2001) 141-146
32. Lin C.Y., and Morel D.W. Distribution of oxysterols in human serum: characterisation of 25-hydroxycholesterol association with serum albumin. J Nutr Biochem 6 (1995) 618-625
33. O'Callaghan Y.C., Woods J.A., and O'Brien N.M. Oxysterol-induced cell death in U937 and HepG2 cells at reduced serum concentrations. Eur J Nutr 38 (1999) 255-262
34. Thompson E.B., and Ayala-Torres S. Oxysterols and apoptosis: evidence for gene regulation outside the cholesterol pathway. Crit Rev Biochem Mol Biol 34 (1999) 25-32
35. Yang L., and Sinensky M.S. 25-hydroxycholesterol activates a cytochrome c release-mediated caspase cascade. Biochem Biophys Res Commun 278 (2000) 557-563
36. Lee T., and Chau L. Fas/Fas ligand-mediated death pathway is involved in oxLDL-induced apoptosis in vascular smooth muscle cells. Am J Physiol Cell Physiol 280 (2001) 709-718
37. Rusinol A.E., Thewke D., Liu J., Freeman N., Panini S.R., and Sinensky M.S. AKT/protein kinase B regulation of BCL family members during oxysterol-induced apoptosis. J Biol Chem 279 (2004) 1392-1399
38. Everett N.B., and Simmons B. Measurement and radioautographic localization of albumin in rat tissues after intravenous administration. Circ Res 6 (1958) 307-313
39. Christensen A.K., Komorowski T.E., Wilson B., Ma S.F., and Stevens III R.W. The distribution of serum albumin in the rat testis, studied by electron microscope immunocytochemistry on ultrathin frozen sections. Endocrinology 116 (1985) 1983-1996
40. Fofana M., Travert C., Carreau S., and Le Goff D. Evaluation of cholesteryl ester transfer in the seminiferous tubule cells of immature rats in vivo and in vitro. J Reprod Fertil 11 (2000) 79-83
41. Sinha Hikim A.P., Lue Y., Diaz-Romero M., Yen P.H., Wang C., and Swerdloff R.S. Deciphering the pathways of germ cell apoptosis in the testis. J Steroid Biochem Mol Biol 85 (2003) 175-182
42. Taylor M.F., De Boer-Brouwer M, Woolveridge I., Teerds K.J., and Morris I.D. Leydig cell apoptosis after the administration of ethane dimethanesulfonate to the adult male rat is a Fas-mediated process. Endocrinology 140 (1999) 3797-3804
43. Travert C., Fofana M., Carreau S., and Le Goff D. Rat Leydig cells use apolipoprotein E depleted high density lipoprotein to regulate testosterone production. Mol Cell Biochem 213 (2000) 51-59
44. Carreau S., Genissel C., Bilinska B., and Levallet J. Sources of oestrogen in the testis and reproductive tract of the male. Int J Androl 22 (1999) 211-223
45. Luconi M., Forti G., and Baldi E. Genomic and nongenomic effects of estrogens: molecular mecanisms of action and clinical implications for male reproduction. J Steroid Biochem Mol Biol 80 (2002) 369-381
46. Haynes L.E., Lendon C.L., Barber D.J., and Mitchell I.J. 17β-Oestradiol attenuates dexamethasone-induced lethal and sublethal neuronal damage in the striatum and hypocampus. Neuroscience 120 (2003) 799-806
47. van Pelt M.M., de Rooij D.G., van der Burg B., van der Saag P.T., Gustafsson J.A., and Kuiper G.J.M. Ontogeny of estrogen receptor-beta expression in rat testis. Endocrinology 140 (1999) 478-483
48. Pelletier G., Labrie C., and Labrie F. Localization of oestrogen receptor α, oestrogen receptor β and androgen receptors in the rat reproductive organs. J Endocrinol 165 (2000) 359-370
49. Lagace T.A., Byers D.M., Cook H.W., and Ridgway N.D. Chinese hamster ovary cells overexpressing the oxysterol binding protein (OSBP) display enhanced synthesis of sphingomyelin in response to 25-hydroxycholesterol. J Lipid Res 40 (1999) 109-116
50. Björkhem I., Andersson O., Diczfalusy U., Sevastik B., and Xiu R.J. Atherosclerosis and sterol 27-hydroxylase: evidence for a role of this enzyme in elimination of cholesterol from human macrophages. Proc Natl Acad Sci USA 91 (1994) 8592-8596