Synthesis of phenanthridinium-bis-nucleobase conjugates, interactions with poly U, nucleotides and in vitro antitumour activity of mono- and bis-nucleobase conjugates

European Journal of Medicinal Chemistry

Volumn 41, Issue 10, 2006, Pages 1153-1166

  Tumir, L M ^a   Piantanida, I ^a   Zinic M ^a   Juranovic Cindric I ^b   Meic Z ^b   Kralj, M ^a   Tomic S ^a  

^a RUDER BO KOVI INSTITUTE   (Croatia)

^b UNIVERSITY OF ZAGREB   (Croatia)

Author keywords

In vitro antitumour activity; Nucleotides; Phenanthridinium bis nucleobase conjugates; Polynucleotides

Indexed keywords

ADENINE; HYDROGEN; NUCLEIC ACID BASE; NUCLEOTIDE; PHENANTHRIDINE DERIVATIVE; POLYURIDYLIC ACID; URACIL; WATER; ANTINEOPLASTIC AGENT; PHENANTHRIDINE;

ANTINEOPLASTIC ACTIVITY; AQUEOUS SOLUTION; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG CONJUGATION; DRUG EFFECT; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYDROGEN BOND; IN VITRO STUDY; SPECTROSCOPY; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DRUG STABILITY; HELA CELL; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SENSITIVITY AND SPECIFICITY; SPECTROFLUOROMETRY; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TIME; TUMOR CELL LINE; ULTRAVIOLET SPECTROPHOTOMETRY;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; DRUG STABILITY; HELA CELLS; HUMANS; HYDROGEN BONDING; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NUCLEOTIDES; PHENANTHRIDINES; POLY U; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, FLUORESCENCE; SPECTROPHOTOMETRY, ULTRAVIOLET; STRUCTURE-ACTIVITY RELATIONSHIP; TIME FACTORS;

EID: 33749631257     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2006.05.005     Document Type: Article

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