Reproductive and developmental toxicity of inhaled 2,3-dichloro-1,3-butadiene in rats

Reproductive Toxicology

Volumn 22, Issue 4, 2006, Pages 613-622

  Mylchreest, E ^a   Malley, L A ^a   O'Neill, A J ^a   Kegelman, T A ^a   Sykes, G P ^a   Valentine, R ^a  

^a DUPONT COMPANY   (United States)

Author keywords

Developmental toxicity; Dichlorobutadiene; Inhalation; Reproductive toxicity

Indexed keywords

2,3 DICHLORO 1,3 BUTADIENE; TOXIC SUBSTANCE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOPSY; COITUS; CONTROLLED STUDY; CYTOTOXICITY; DEVELOPMENTAL DISORDER; DYSPNEA; ENVIRONMENTAL EXPOSURE; ESTRUS CYCLE; FEMALE; FETUS RISK; FOOD INTAKE; GENITAL SYSTEM; MALE; MATING; NONHUMAN; OLFACTORY EPITHELIUM; RAT; REPRODUCTIVE TOXICITY; SKELETON; SPERM; TISSUE DEGENERATION; TOXICITY TESTING; VISCERA; WEIGHT REDUCTION;

ADMINISTRATION, INHALATION; ANIMALS; ATMOSPHERE; CHLOROPRENE; DOSE-RESPONSE RELATIONSHIP, DRUG; EATING; EMBRYONIC DEVELOPMENT; FEMALE; FETAL WEIGHT; KIDNEY; KIDNEY PELVIS; LIVER; MALE; MATERNAL EXPOSURE; NO-OBSERVED-ADVERSE-EFFECT LEVEL; OLFACTORY MUCOSA; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCTION; SEX FACTORS; WEIGHT GAIN;

ANIMALIA;

EID: 33749618670     PISSN: 08906238     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.reprotox.2006.04.002     Document Type: Article

References (29)

1. Khechumov S.A., Gizhlaryan M.S., and Khechumova R.M. Toxicological characteristics of a new dichlorobutadiene monomer for synthetic rubber. Toksikol Gig Prod Neftekhim Neftekhim Proizvod (1972) 208-211
2. Vardanyan M.V., Gizhlaryan M.S., and Khechumov S.A. Gonadotropic effect of dichlorobutadiene in long-term experiments. Gigiena i Sanitariya 8 (1976) 96-98
3. Leblond C.P., and Clermont Y. Definition of the stages of the cycle of the seminiferous epithelium of the rat. Ann N Y Acad Sci 55 (1952) 548-573
4. OECD, Good Laboratory Practice Standards, ENV/MC/CHEM(98)17; 1997.
5. TSCA, Good Laboratory Practice Standards, 40 CFR Part 792; 1989.
6. EPA, Health Effects Test Guidelines, OPPTS 870.3700 Prenatal Developmental Toxicity Study; 1998.
7. OECD, Guidelines for Testing of Chemicals, Section 4, No. 415; 1983.
8. OECD, Guidelines for Testing of Chemicals, Section 4, No. 414; 2001.
9. Stewart C.A. Dimerization of chloroprene and related dienes. J Am Chem Soc 93 19 (1971) 4815-4821
10. Salewski E. Farbemethode zum makroskopischen nachweis van implantationstellen am uterus der ratte. Arch Path Exp Pharmakol 246 (1964) 367-382
11. Staples R.E. Detection of visceral alterations in mammalian fetuses. Teratology 9 (1974) A37-A38
12. Woo D.C., and Hoar R.M. Apparent hydronephrosis as a normal aspect of renal development in late gestation of rats: the effect of methyl salicylate. Teratology 6 (1972) 191-196
13. Barrow M.V., and Taylor W.J. A rapid method for detecting malformations in rat fetuses. J Morph 127 (1969) 291-306
14. Staples R.E., and Schnell V.L. Refinement in rapid clearing technique in the KOH-alizarin red S method for fetal bone. Stain Technol 39 (1963) 61
15. Haseman J.K., and Hogan M.D. Selection of the experimental unit in teratology studies. Teratology 12 2 (1975) 165-171
16. Shapiro S.S., and Wilk M.B. An analysis of variance test for normality (complete samples). Biometrika 52 (1965) 591-611
17. Levene H. Robust test for equality of variances. In: Olkin J. (Ed). Contributions to probability and statistics (1960), Stanford University Press, Palo Alto 278-292
18. Dunnett C.W. New tables for multiple comparisons with a control. Biometrics 20 (1964) 482-491
19. Dunnett C.W. Pairwise multiple comparisons in the unequal variance case. J Amer Statist Assoc 75 (1980) 796-800
20. Tamhane A.C. A comparison of procedures for multiple comparison of means with unequal variances. J Amer Statist Assoc 74 (1979) 471-480
21. Dunn O.J. Multiple contrasts using rank sums. Technometrics 6 (1964) 241-252
22. Snedecor G.W., and Cochran W.G. Statistical methods (1967), The Iowa State University Press, Iowa p. 246-8, 349-52
23. Mehta C.R., Patel N.R., and Tsiatis A.A. Exact significance testing to establish treatment equivalence with ordered categorical data. Biometrics 40 (1984) 819-825
24. Agresti A. A survey of exact inference for contingency tables. Stat Sci 7 1 (1992) 131-177
25. Hsu J.C. The factor analytic approach to simultaneous inference in the general linear model. J Comput Graph Stat 1 (1992) 151-168
26. Milliken G.A., and Johnson D.A. Analysis of messy data. Designed experiments vol. 1 (1984), Lifetime Learning Publications, Belmont
27. Young J.T. Histopathologic examination of the rat nasal cavity. Fundam Appl Toxicol 1 4 (1981) 309-312
28. Cattley R.C., and Popp J.A. Liver. In: Haschek W.M., Rousseaux C.G., and Wallig M.A. (Eds). Handbook of toxicologic pathology (2002), Academic Press, New York 202
29. Khan K.N.M., and Alden C.L. Kidney. In: Haschek W.M., Rousseaux C.G., and Wallig M.A. (Eds). Handbook of toxicologic pathology (2002), Academic Press, New York 269