Stillbirth and slow metabolizers of caffeine: Comparison by genotypes

International Journal of Epidemiology

Volumn 35, Issue 4, 2006, Pages 948-953

  Bech, Bodil Hammer ^a   Autrup, Herman ^b   Nohr, Ellen Aagaard ^a   Henriksen, Tine Brink ^c   Olsen, Jørn ^a,d  

^a UNIVERSITY OF AARHUS   (Denmark)

^b AARHUS UNIVERSITY   (Denmark)

^c AARHUS UNIVERSITY HOSPITAL   (Denmark)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Caffeine; CYP1A2; GSTA1; NAT2; Stillbirth

Indexed keywords

ARYLAMINE ACETYLTRANSFERASE; CAFFEINE; CYTOCHROME P450 1A2; GLUTATHIONE TRANSFERASE;

CYTOCHROME; ENZYME; GENOTYPE; METABOLISM;

ADULT; ARTICLE; CASE CONTROL STUDY; COFFEE; CONFIDENCE INTERVAL; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; FOOD INTAKE; GENETIC ASSOCIATION; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; OXIDATIVE STRESS; PREGNANCY; PRIORITY JOURNAL; RANDOMIZATION; RISK ASSESSMENT; STILLBIRTH;

ACETYLTRANSFERASES; CAFFEINE; CASE-CONTROL STUDIES; CYTOCHROME P-450 CYP1A2; FEMALE; GENOTYPE; GLUTATHIONE TRANSFERASE; HUMANS; LOGISTIC MODELS; ODDS RATIO; POLYMORPHISM, GENETIC; PREGNANCY; RISK ASSESSMENT; STILLBIRTH;

EID: 33749597411     PISSN: 03005771     EISSN: 14643685     Source Type: Journal    
DOI: 10.1093/ije/dyl116     Document Type: Article

References (31)

1. Garattini S. Caffeine, Coffee and Health. New York: Raven Press, 1993.
2. Wisborg K, Kesmodel U, Bech BH, Hedegaard M, Henriksen TB. Maternal consumption of coffee during pregnancy and stillbirth and infant death in first year of life: Prospective study. BMJ 2003; 326:420.
3. Cnattingius S, Signorello LB, Anneren G et al. Caffeine intake and the risk of first-trimester spontaneous abortion. N Engl J Med 2000;343: 1839-45.
4. Wen W, Shu XO, Jacobs DR Jr, Brown JE. The associations of maternal caffeine consumption and nausea with spontaneous abortion. Epidemiology 2001;12:38-42.
5. Rasch V. Cigarette, alcohol, and caffeine consumption: Risk factors for spontaneous abortion. Acta Obstet Gynecol Scand 2003;82:182-88.
6. Giannelli M, Doyle P, Roman E, Pelerin M, Hermon C. The effect of caffeine consumption and nausea on the risk of miscarriage. Paediatr Perinat Epidemiol 2003;17:316-23.
7. Lawson CC, LeMasters GK, Wilson KA. Changes in caffeine consumption as a signal of pregnancy. Reprod Toxicol 2004;18:625-33.
8. Butler MA, Iwasaki M, Guengerich FP, Kadlubar FF. Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines. Proc Natl Acad Sci USA 1989;86:7696-700.
9. Arnaud MJ. Metabolism of caffeine and other components of coffee. In: Garattini S (ed.). Caffeine, Coffee, and Health. New York: Raven Press, 1993, pp. 43-95.
10. Scholl TO, Stein TP. Oxidant damage to DNA and pregnancy outcome. J Matern Fetal Med 2001;10:182-85.
11. Olsen J, Melbye M, Olsen SF et al. The Danish National Birth Cohort - its background, structure and aim. Scand J Public Health 2001;29:300-07.
12. Chida M, Yokoi T, Fukui T, Kinoshita M, Yokota J, Kamataki T. Detection of three genetic polymorphisms in the 5′-flanking region and intron 1 of human CYP1A2 in the Japanese population. Jpn J Cancer Res 1999;90:899-902.
13. Sachse C, Bhambra U, Smith G et al. Polymorphisms in the cytochrome P450 CYP1A2 gene (CYP1A2) in colorectal cancer patients and controls: Allele frequencies, linkage disequilibrium and influence on caffeine metabolism. Br J Clin Pharmacol 2003;55:68-76.
14. Sachse C, Smith G, Wilkie MJ et al. A pharmacogenetic study to investigate the role of dietary carcinogens in the etiology of colorectal cancer. Carcinogenesis 2002;23:1839-49.
15. Coles BF, Morel F, Rauch C et al. Effect of polymorphism in the human glutathione S-transferase A1 promoter on hepatic GSTA1 and GSTA2 expression. Pharmacogenetics 2001;11:663-69.
16. Little RE, Weinberg CR. Risk factors for antepartum and intrapartum stillbirth. Am J Epidemiol 1993;137:1177-89.
17. Bech BH, Nohr EA, Vaeth M, Henriksen TB, Olsen J. Coffee and fetal death: A cohort study with prospective data. Am J Epidemiol 2005;162:983-90.
18. Davey Smith G, Ebrahim S. 'Mendelian randomization': Can genetic epidemiology contribute to understanding environmental determinants of disease? Int J Epidemiol 2003;32:1-22.
19. Fenster L, Quale C, Hiatt RA, Wilson M, Windham GC, Benowitz NL. Rate of caffeine metabolism and risk of spontaneous abortion. Am J Epidemiol 1998;147:503-10.
20. Signorello LB, Nordmark A, Granath F et al. Caffeine metabolism and the risk of spontaneous abortion of normal karyotype fetuses. Obstet Gynecol 2001;98:1059-66.
21. Garrett BE, Griffiths RR. Physical dependence increases the relative reinforcing effects of caffeine versus placebo. Psychopharmacology (Berl) 1998;139:195-202.
22. Moonen HJ, Moonen EJ, Maas L, Dallinga JW, Kleinjans JC, de Kok TM. CYP1A2 and NAT2 genotype/phenotype relations and urinary excretion of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in a human dietary intervention study. Food Chem Toxicol 2004;42:869-78.
23. Gross M, Kruisselbrink T, Anderson K et al. Distribution and concordance of N-acetyltransferase genotype and phenotype in an American population. Cancer Epidemiol Biomarkers Prev 1999;8: 683-92.
24. Tsutsumi K, Kotegawa T, Matsuki S et al. The effect of pregnancy on cytochrome P4501A2, xanthine oxidase, and N-acetyltransferase activities in humans. Clin Pharmacol Ther 2001;70:121-25.
25. Kalow W, Tang BK. Caffeine as a metabolic probe: Exploration of the enzyme-inducing effect of cigarette smoking. Clin Pharmacol Ther 1991;49:44-48.
26. Vistisen K, Poulsen HE, Loft S. Foreign compound metabolism capacity in man measured from metabolites of dietary caffeine. Carcinogenesis 1992;13:1561-68.
27. Rasmussen BB, Brix TH, Kyvik KO, Brosen K. The interindividual differences in the 3-demthylation of caffeine alias CYP1A2 is determined by both genetic and environmental factors. Pharmacogenetics 2002;12:473-78.
28. Castorena-Torres F, Mendoza-Cantu A, de Leon MB et al. CYP1A2 phenotype and genotype in a population from the Carboniferous Region of Coahuila, Mexico. Toxicol Lett 2005;156:331-39.
29. Sachse C, Brockmoller J, Bauer S, Roots I. Functional significance of a C→A polymorphism in intron 1 of the cytochrome P450 CYP1A2 gene tested with caffeine. Br J Clin Pharmacol 1999;47:445-49.
30. Pavanello S, Pulliero A, Lupi S, Gregorio P, Clonfero E. Influence of the genetic polymorphism in the 5′-noncoding region of the CYP1A2 gene on CYP1A2 phenotype and urinary mutagenicity in smokers. Mutat Res 2005;587:59-66.
31. Nordmark A, Lundgren S, Ask B, Granath F, Rane A. The effect of the CYP1A2 *1F mutation on CYP1A2 inducibility in pregnant women. Br J Clin Pharmacol 2002;54:504-10.