Metformin treatment is effective in obese teenage girls with PCOS

Human Reproduction

Volumn 21, Issue 9, 2006, Pages 2252-2256

  De Leo, Vincenzo ^a   Musacchio, M C ^a   Morgante, G ^a   Piomboni, P ^a   Petraglia, F ^a  

^a UNIVERSITY OF SIENA   (Italy)

Author keywords

Adolescents; Androgens; Hirsutism; Metformin; Obese; PCOS

Indexed keywords

ANDROSTENEDIONE; GLUCOSE; METFORAL; METFORMIN; PROGESTERONE; TESTOSTERONE;

ACNE; ADOLESCENT; ADULT; ARTICLE; BODY MASS; BODY WEIGHT; CLINICAL ARTICLE; CLINICAL FEATURE; CONSENSUS; DRUG DOSE REGIMEN; DRUG EFFICACY; DRUG MECHANISM; FEMALE; FOLLOW UP; GLUCOSE BLOOD LEVEL; HIRSUTISM; HUMAN; HYPERANDROGENISM; LUTEAL PHASE; MENSTRUAL CYCLE; OBESITY; OVARY FUNCTION; OVARY POLYCYSTIC DISEASE; OVULATION; PROGESTERONE BLOOD LEVEL; TESTOSTERONE BLOOD LEVEL; TREATMENT DURATION; UNSPECIFIED SIDE EFFECT; WEIGHT GAIN;

EID: 33749581464     PISSN: 02681161     EISSN: 14602350     Source Type: Journal    
DOI: 10.1093/humrep/del185     Document Type: Article

References (28)

1. Adams J, Polson DW and Franks S (1986) Prevalence of polycystic ovaries in women with anovulation and idiopathic hirsutism. Br Med J 293,355-359.
2. Anderson P, Seljeflot I, Abdelnoor M, Arnesen H, Dale PO, Lovik A and Birkeland K (1995) Increased insulin sensitivity and fibrinolytic capacity after dietary intervention in obese women with polycystic ovary syndrome. Metabolism 44(5),611-616.
3. Apter D, Bützow T, Laughlin A and Yen SS (1995) Metabolic features of polycystic ovary syndrome are found in adolescent girls with hyperandrogenism. J Clin Endocrinol Metab 80,2966-2973.
4. Arslanian SA, Lewy V, Danadian K and Saad R (2002) Metformin therapy in obese adolescents with polycystic ovary syndrome and impaired glucose tolerance: Amelioration of exaggerated adrenal response to adrenocorticotropin with reduction of insulinemia/insulin resistance. J Clin Endocrinol Metab 87,1555-1559.
5. Chang JR, Nakamura RM, Judd HL and Kaplan SA (1983) Insulin resistance in nonobese patients with polycystic ovarian disease. J Clin Endocrinol Metab 57,356-359.
6. De Leo V, La Marca A, Ditto A, Morgante G and Cianci A (1999) Effects of metformin on gonadotropin-induced ovulation in women with polycystic ovary syndrome. Fertil Steril 72,282-285.
7. De Leo V, La Marca A and Petraglia F (2003) Insulin-lowering agents in the management of polycystic ovary syndrome. Endocr Rev 24,633-667.
8. Ehrmann DA, Barnes RB and Rosenfield RL (1995) Polycystic ovary syndrome as a form of functional ovarian hyperandrogenism due to dysregulation of androgen secretion. Endocr Rev 16,322-353.
9. Gilling-Smith C and Franks S (1993) Polycystic ovary syndrome. Reprod Med Rev 2,15-32.
10. Hatch R, Rosenfield R, Kim MH and Tredway D (1981) Hirsutism: implications, etiology, and management. Am J Obstet Gynecol 140,815-826.
11. Ibanez L, Valls C, Potau N, Marcos MV and De Zegher F (2000) Sensitization to insulin in adolescent girls to normalize hirsutism, hyperandrogenism, oligomenorrhea, dyslipidemia, and hyperinsulinism after precocious pubarche. J Clin Endocrinol Metab 85,3526-3530.
12. Ibanez L, Valls C, Ferrer A, Marcos MV, Rodriguez-Hierro F and de Zegher F (2001) Sensitization to insulin induces ovulation in nonobese adolescents with anovulatory hyperandrogenism. J Clin Endocrinol Metab 86,3595-3598.
13. Jalal I, Naiker P, Reddi K, Moodley J and Joubert SM (1987) Evidence for insulin resistance in nonobese patients with polycystic ovarian disease after inhibition of ovarian steroid secretion. Fertil Steril 45,327-333.
14. La Marca A, Egbe TO, Morgante G, Paglia T, Cianci A and De Leo V (2000) Metformin treatment reduces ovarian cytochrome P-450c17α response to human chorionic gonadotrophin in women with insulin resistance-related polycystic ovary syndrome. Hum Reprod 15,21-23.
15. Lemay A and Poulin Y (2002) Oral contraceptives as anti-androgenic treatment of acne. J Obstet Gynaecol Can 24,559-567.
16. Metcalf MG, Skidmore DS, Lowry GF and Mackenzie JA (1983) Incidence of ovulation in the years after the menarche. J Endocrinol 97,213-219.
17. Michelmore KF, Balen AH, Dunger DB and Vessey MP (1999) Polycystic ovaries and associated clinical and biochemical features in young women. Clin Endocrinol 51,779-786.
18. Nestler JE, Jakubowicz DJ, Evans WS and Pasquali R (1998) Effects of metformin on spontaneous and clomiphene-induced ovulation in the polycystic ovary syndrome. N Engl J Med 338,1876-1880.
19. Pasquali R, Antenucci D, Casimirri F, Venturoli S, Paradisi R, Fabbri F, Balestra V, Melchionda N and Barbara L (1989) Clinical and hormonal characteristics of obese amenorrheic hyperandrogenic women before and after weight loss. J Clin Endocrinol Metab 68(1),173-179.
20. Poretsky L, Cataldo NA, Rosenwaks Z and Giudice LC (1999) The insulin-related ovarian regulatory system in health and disease. Endocr Rev 20,535-582.
21. Preziosi P, Barrett-Connor E, Papoz L, Roger M, Saint-Paul M, Nahoul K and Simon D (1993) Interrelation between plasma sex hormone-binding globulin and plasma insulin in healthy adult women: The telecom study. J Clin Endocrinol Metab 76,283-287.
22. Rosenfield RL, Ghai K, Ehrmann DA and Barnes RB (2000) Diagnosis of the polycystic ovary syndrome in adolescence: Comparison of adolescent and adult hyperandrogenism. J Pediatr Endocrinol Metab 13,1285-1289.
23. The Rotterdam ESHRE/ASRM-sponsored PCOS consensus workshop group (2004) Revised consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod 19,41-47.
24. Van Hooff MH, Voorhorst FJ, Kaptein MB, Hirasing RA, Koppenaal C and Schoemaker J (2000) Polycystic ovaries in adolescents and the relationship with menstrual cycle patterns, luteinizing hormone, androgens, and insulin. Fertil Steril 74,49-58.
25. Van Hooff MH, Voorhorst FJ, Kaptein MB, Hirasing RA, Koppenaal C and Schoemaker J (2004) Predictive value of menstrual cycle pattern, body mass index, hormone levels and polycystic ovaries at age 15 years for oligoamenorrhoea at age 18 years. Hum Reprod 19,383-392.
26. Wajchenberg BL, Achando SS, Okada H, Czeresnia CE, Peixoto S, Lima SS and Goldman J (1986) Determination of the sources of androgen overproduction in hirsutism associated with polycystic ovary syndrome by simultaneous adrenal and ovarian venous catheterization: Comparison with the dexamethasone suppression test. J Clin Endocrinol Metab 63,1204-1210.
27. Waldestreicher J, Santoro NF, Hall JE, Filicori M and Crowley WF Jr (1988) Hyperfunction of the hypothalamic-pituitary axis in women with polycystic ovary disease: Indirect evidence for partial gonadotroph desensitization. J Clin Endocrinol Metab 66,165-172.
28. Wiegratz I and Kuhl H (2002) Managing cutaneous manifestations of hyperandrogenic disorders: The role of oral contraceptives. Treat Endocrinol 1,372-386.