Granuloma caused by subcutaneous injection of leuprorelin acetate product: Case report and histopathological findings

Journal of Dermatology

Volumn 33, Issue 10, 2006, Pages 719-721

  Ouchi, Takeshi ^a   Koyama, Tetushi ^a   Miyata, Naho ^a   Sugiura, Makoto ^a  

^a Shizuoka Municipal Shimizu Hospital ^*  (Japan)

Author keywords

Granuloma; Lactic acid; Leuprorelin; Subcutaneous injection; Vacuoles

Indexed keywords

CARBONIC ACID; GLYCOLIC ACID; GONADORELIN DERIVATIVE; GOSERELIN; LACTIC ACID; LEUPRIN; LEUPRIN SR; LEUPRORELIN; SEX HORMONE;

AGED; ARTICLE; CANCER HORMONE THERAPY; CANCER SURGERY; CASE REPORT; CASTRATION; CELL VACUOLE; DRUG WITHDRAWAL; GIANT CELL; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; INJECTION SITE EROSION; INJECTION SITE GRANULOMA; MALE; MICROCAPSULE; PROSTATE CANCER; PROSTATECTOMY; PUS; SKIN GRANULOMA; SKIN ULCER; SUBCUTANEOUS NODULE;

AGED; ANTINEOPLASTIC AGENTS, HORMONAL; GRANULOMA; HUMANS; INJECTIONS, SUBCUTANEOUS; LEUPROLIDE; MALE; SKIN DISEASES;

EID: 33749578090     PISSN: 03852407     EISSN: 13468138     Source Type: Journal    
DOI: 10.1111/j.1346-8138.2006.00167.x     Document Type: Article

References (10)

1. Okada H. One- and three-month release injectable microspheres of the LH-RH superagonist leuprorelin acetate. Adv Drug Deliv Rev 1997; 28: 43-70.
2. Toguchi H. Pharmaceutical manipulation of leuprorelin acetate to improve clinical performance. J Int Med Res 1990; 18 (Suppl 1): 35-41.
3. Okada H, Doken Y, Ogawa Y. Persistent suppression of the pituitary-gonadal system in female rats by three-month depot injectable microspheres of leuprorelin acetate. J Pharm Sci 1996; 85: 1044-48.
4. Whitaker IS, Fazel MZ, Joshi HB et al. Leuprorelin acetate granulomas: recurrent subcutaneous nodules mimicking metastatic deposits at injection sites. BJU Int 2002; 90: 350.
5. Saxby M. Leuprorelin acetate granulomas: recurrent subcutaneous nodules mimicking metastatic deposits at injections sites. BJU Int 2003; 91: 125.
6. Yasukawa K, Sawamura D, Sugawara H, Kato N. Leuprorelin acetate granulomas: case reports and review of the literature. Br J Dermatol 2005; 152: 1045-7.
7. Tachibana M, Yamano Z, Kusuda Y et al. Cutaneous epithelioid granuloma induced by subcutaneous injection of leuprorelin acetate: a case report. Hinyokika Kiyo 2004; 50: 199-202.
8. Mizoguchi K, Hamasaki Y, Kanayama I et al. A case of drug induced granulomatous reaction by leuprorelin acetate. Jpn J Dermatol 2004; 114: 163-7.
9. Hiroshima N, Shinogi T, Sakashita N et al. A case of cutaneous injury induced by injection of leuprorelin acetate. Nishinihon J Dermatol 2001; 63:384-6.
10. Muya M, Takijiri C, Shirahara S. Two cases of granuloma caused by subcutaneous injection of leuprorelin acetate. Jpn J Clin Dermatol 1999; 53: 801-3.