Effect of protein kinase C on T lymphocyte proliferation and apoptosis in acute idiopathic thrombocytopenic purpura

Acta Haematologica

Volumn 116, Issue 3, 2006, Pages 173-180

  Liu, Fang ^a   Wu, Chang Lin ^a   Xiao, Hong ^a   Yang, Xiao Meng ^a   Lv, Xue Wen ^a   Chen, Qun ^a  

^a GUANGDONG MEDICAL UNIVERSITY   (China)

Author keywords

Idiopathic thrombocytopenic purpura; Protein kinase C; T lymphocytes

Indexed keywords

1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; FAS LIGAND; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR;

ADOLESCENT; APOPTOSIS; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL PROLIFERATION; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME ACTIVITY; FEMALE; HUMAN; IDIOPATHIC THROMBOCYTOPENIC PURPURA; INFANT; MALE; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; T LYMPHOCYTE; THROMBOCYTE ANOMALY; THROMBOCYTE COUNT;

ACUTE DISEASE; ADOLESCENT; APOPTOSIS; CELL PROLIFERATION; CHILD; CHILD, PRESCHOOL; DNA; ELECTROPHORESIS, AGAR GEL; FAS LIGAND PROTEIN; FEMALE; HUMANS; INFANT; MALE; MEMBRANE GLYCOPROTEINS; PROTEIN KINASE C; PURPURA, THROMBOCYTOPENIC, IDIOPATHIC; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TUMOR NECROSIS FACTORS;

EID: 33749568949     PISSN: 00015792     EISSN: None     Source Type: Journal    
DOI: 10.1159/000094677     Document Type: Article

References (20)

1. Nugent DJ: Childhood immune thrombocytopenic purpura. Blood Rev 2002;16:27-29.
2. Gao QP, Huang WX, Li XZ: The expression of apoptosis protein in the lymphocyte and platelet from patients with chronic idiopathic thrombocytopenic purpura. J Clin Hematol 2001;14:104-106.
3. Liu F, Yang XM, Chen Q, Xiao H, Zhao D, Cai KR: The significance of CRTH2 expression on T cell subsets in patients with idiopathic thrombocytopaenic purpura. Chin J Microbiol Immunol 2004;24:755-758.
4. Schwacha MG, Ayala A, Cioffi WG, Bland KI, Chaudry IH: Role of protein kinase C cyclic AMP-mediated suppression of T-lymphocyte activation following burn injury. Biochim Biophys Acta 1999;1455:45-53.
5. Gomez-Angelats M, Cidlowski JA: Protein kinase C regulates FADD recruitment and death-inducing signaling complex formation in Fas/CD95-induced apoptosis. Biol Chem 2001;276:44944-44952.
6. Luo CH, Liao QK, Jia CS: The diagnostic and treated recommend of idiopathic thrombocytopenic purpura. Chin J Pediatr 1999;37:50-51.
7. Schondorf T, Kurbacher CM, Becker M, Warm M, Kolhagen H, Gohring UJ: Heterogeneity of protein kinase C activity and PKC-zeta expression in clinical breast carcinomas. Clin Exp Med 2001;1:1-8.
8. Xiong WN, Xu YJ, Zhang ZX, Sheng GX, Xiong SD: A study on the effect of PKC on the T cell proliferation and apoptosis in asthma patient. Zhonghua J Tuberc Respir 2001;24:629-630.
9. Tada Y, Nagasawa K, Yamauchi Y, Tsukamoto H, Niho Y: A defect in the protein kinase C system in T cells from patients with systemic lupus erythematosus. Clin Immunol Immunopathol 1991;60:220-231.
10. Iori E, Marescotti MC, Vedovato M, Ceolotto G, Avogaro A, Tiengo A, Trevisan R: In situ protein kinase C activity is increased in cultured fibroblasts from type 1 diabetic patients with nephropathy. Diabetologia 2003;46:524-530.
11. Olsson B, Andersson PO, Jacobsson S, Carlsson L, Wadenvik H: Disturbed apoptosis of T-cells in patients with active idiopathic thrombocytopenic purpura. Thromb Haemost 2005;93:139-144.
12. Ruiz MC, Izquierdo M, Murcia GD, Lopez-Rivas A: Activation of protein kinase C attenuates early signals in Fas-mediated apoptosis. Eur J Immunol 1997;27:1442-1450.
13. Noble A, Truman JP, Vyas B, Vukmanovic-Stejic M, Hirst WJ, Kemeny DM: The balance of protein kinase C and calcium signaling directs T cell subset development. J Immunol 2000;164:1807-1813.
14. Isakov N, Altman A: Protein kinase C (PKC) in T cell activation. Annu Rev Immunol 2002;20:761-794.
15. Olsson B, Andersson PO, Jernas M, Jacobsson S, Carlsson LMS, Wadenvik H: T-cell-mediated cytotoxicity toward platelets in chronic idiopathic thrombocytopenic purpura. Nat Med 2003;9:1123-1124.
16. Yoshimura C, Nomura S, Nagahama M, Ozaki Y, Kagawa H, Fukuhara S: Plasma-soluble Fas(Apo-1, CD95) and Fas ligand in immune thrombocytopenic purpura. Eur J Haematol 2000;64:219-224.
17. Guo BC, Xu YH: Bcl-2 over-expression and activation of protein kinase C suppress the trail-induced apoptosis in Jurkat T cells. Cell Res 2001;11:101-106.
18. Liu F, Xiao H, Meng Q, Cai KR, Wu CL: A study on apoptosis of lymphocytes and expression of apoptotic protein in patients with idiopathic thrombocytopenic purpura. Chin J Immunol 2004;20:202-205.
19. Mouzaki A, Theodoropoulou M, Gianakopoulos I, Vlaha V, Kyrtsonis MC, Maniatis A: Expression patterns of Th1 and Th2 cytokine genes in childhood idiopathic thrombocytopenic purpura (ITP) at presentation and their modulation by intravenous immunoglobulin G (IVIg) treatment: their role in prognosis. Blood 2002;100:1774-1779.
20. Liao WT, Chang KL, Yu CL, Chen GS, Chang LW, Yu HS: Arsenic induces human keratinocyte apoptosis by the Fas/FasL pathway, which correlates with alterations in nuclear factor-kappa B and activator protein-1 activity. Invest Dermatol 2004;122:125-129.