Gemcitabine and oxaliplatin in patients with metastatic breast cancer resistant to or pretreated with both anthracyclines and taxanes: Clinical and pharmacokinetic data

American Journal of Clinical Oncology: Cancer Clinical Trials

Volumn 29, Issue 5, 2006, Pages 490-494

  Airoldi, Mario ^a   Cattel, Luigi ^b   Passera, Roberto ^b   Pedani, Fulvia ^a   Delprino, Laura ^b   Micari, Caterina ^b  

^a MOLINETTE HOSPITAL   (Italy)

^b UNIVERSITY OF TURIN   (Italy)

Author keywords

Breast cancer; Gemcitabine; Metastases; Oxaliplatin; Pharmacokinetics; Pharmacoresistance

Indexed keywords

ANTHRACYCLINE ANTIBIOTIC AGENT; GEMCITABINE; NAVELBINE; OXALIPLATIN; TAXANE DERIVATIVE;

ADULT; AGED; ALOPECIA; ANEMIA; ARTICLE; BLOOD TOXICITY; BREAST CANCER; CANCER ADJUVANT THERAPY; CANCER COMBINATION CHEMOTHERAPY; CANCER GROWTH; CANCER RELAPSE; CANCER RESISTANCE; CLINICAL ARTICLE; CLINICAL TRIAL; DIARRHEA; DISEASE SEVERITY; DRUG BLOOD LEVEL; DRUG DOSE REGIMEN; DRUG EFFICACY; DRUG RESPONSE; DRUG TOLERABILITY; FEBRILE NEUTROPENIA; FEMALE; GASTROINTESTINAL TOXICITY; HUMAN; LEUKOPENIA; METASTASIS; NAUSEA; NEUROTOXICITY; NEUTROPENIA; PERIPHERAL NEUROPATHY; PHASE 2 CLINICAL TRIAL; SENSORY NEUROPATHY; SURVIVAL RATE; THROMBOCYTOPENIA; VISCERAL METASTASIS; VOMITING;

ADULT; AGED; ANTHRACYCLINES; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BREAST NEOPLASMS; DEOXYCYTIDINE; DRUG RESISTANCE, NEOPLASM; FEMALE; HUMANS; LIVER NEOPLASMS; MIDDLE AGED; NEOPLASM METASTASIS; ORGANOPLATINUM COMPOUNDS; PROSPECTIVE STUDIES; SURVIVAL ANALYSIS; TAXOIDS;

EID: 33749560692     PISSN: 02773732     EISSN: 1537453X     Source Type: Journal    
DOI: 10.1097/01.coc.0000231363.95334.ee     Document Type: Article

References (25)

1. Joensuu H. Treatment of locally advanced and metastatic breast cancer. In: Souhami RL, Tannock I, Hohenberger P, et al, eds. Oxford Textbook of Oncology, Vol. 2. New York: Oxford University Press; 2002:1763-1786.
2. Perez EA. Current management of metastatic breast cancer. Semin Oncol. 1999;26(suppl 12):1-10.
3. Crown A, Dieras V, Kaufman M, et al. Chemotherapy for metastatic breast cancer: report of an European expert panel. Lancet Oncol. 2002;3:719-726.
4. Fossati R, Confalonieri C, Torri V, et al. Cytotoxic and hormonal treatment for metastatic breast cancer: a systematic review of published randomized trials involving 31,510 women. J Clin Oncol. 1998;16:3439-3460.
5. Decatris MP, Sundar S, O'Byrne KJ. Platinum-based chemotherapy in metastatic breast cancer: current status. Cancer Treat Rev. 2004;30:53-81.
6. Carmichael J. The role of gemcitabine in the treatment of other tumors. Br J Cancer. 1998;78(suppl 3):21-25.
7. Tempero M, Plunkett W, Ruiz van Haperen V, et al. Randomized phase II comparison of dose-intense gemcitabine: thirty-minute infusion and fixed dose rate infusion in patients with pancreatic adenocarcinoma. J Clin Oncol. 2003;21:3402-3408.
8. Lüftner D, Flath B, Akrivakis C, et al. Gemcitabine for palliative treatment in metastatic breast cancer. J Cancer Res Clin Oncol. 1998;124:527-531.
9. Peters GJ, Bergman AM, Ruiz van Haperen VW, et al. Interaction between cisplatin and gemcitabine in vitro and in vivo. Semin Oncol. 1995;22(suppl 11):72-79.
10. van Moorsel CJ, Veerman G, Bergman AM, et al. Combination chemotherapy studies with gemcitabine. Semin Oncol. 1997;24(suppl 7):17-23.
11. Nagourney RA, Link JS, Blitzer JB, et al. Gemcitabine plus cisplatin repeating doublet therapy in previously treated, relapsed breast cancer patients. J Clin Oncol. 2000;18:2245-2249.
12. Raymond E, Faivre S, Woynarowski JM, et al. Oxaliplatin: mechanism of action and antineoplastic activity. Semin Oncol. 1998;25(suppl 5):4-12.
13. Chollet P, Bensmaine MA, Brienza S, et al. Single agent activity of oxaliplatin in heavily pretreated advanced epithelial ovarian cancer. Ann Oncol. 1996;7:1065-1070.
14. Garufi C, Nistico C, Brienza S, et al. Single agent oxaliplatin in pretreated advanced breast cancer patients: a phase II study. Ann Oncol. 2001;12:179-182.
15. Faivre S, Raymond E, Woynarowski JM, et al. Supraadditive effect of 2′,2′-difluorodeoxycytidine (gemcitabine) in combination with oxaliplatin in human cancer cell lines. Cancer Chemother Pharmacol. 1999;44:117-123.
16. Faivre S, Le Chevalier T, Monnerat C, et al. Phase I-II and pharmacokinetic study of gemcitabine combined with oxaliplatin in patients with advanced non-small-cell lung cancer and ovarian carcinoma. Ann Oncol. 2002;13:1479-1489.
17. Alberts SR, Townley PM, Goldberg RM, et al. Gemcitabine and oxaliplatin for patients with advanced or metastatic pancreatic cancer: a North Central Cancer Treatment Group (NCCTG) phase I study. Ann Oncol. 2002;13:553-557.
18. Mavroudis D, Pappas P, Kouroussis C, et al. A dose-escalation and pharmacokinetic study of gemcitabine and oxaliplatin in patients with advanced solid tumors. Ann Oncol. 2003;14:304-312.
19. Freeman KB, Anliker S, Hamilton M, et al. Validated assays for the determination of gemcitabine in human plasma and urine using high-performance liquid chromatography with ultraviolet detection. J Chromatogr B. 1995;665:171-181.
20. van Warmerdam LJC, van Tellingen O, Maes RAA, et al. Validated method for determination of carboplatin in biological fluids by Zeeman atomic absorption spectrometry. Fres J Anal Chem. 1995;351:777-781.
21. Louvet C, Lledo AG, Hammel P, et al. Gemcitabine combined with oxaliplatin in advanced pancreatic carcinoma: final results of a GERCOR multicenter phase II study. J Clin Oncol. 2002;20:1512-1518.
22. Burch PA, Mailliard JA, Hillman DW, et al. Phase II study of gemcitabine plus cisplatin in patients with metastatic breast cancer: a North Central Cancer Treatment Group Trial. Am J Clin Oncol. 2005;28:195-200.
23. Pectasides D, Pectasides M, Farmakis D, et al. Oxaliplatin plus high-dose leucovorin and 5-fluorouracil in pretreated advanced breast cancer: a phase II study. Ann Oncol. 2003;14:537-542.
24. Avada A, Biganzoli L, Cufer T, et al. An EORTC-IDBBC phase I study of gemcitabine and continuos infusion 5-fluorouracil in patients with metastatic breast cancer resistant to anthracyclines or pre-treated with both anthracyclines and taxanes. Eur J Cancer. 2002;38:773-778.
25. Mariani G, Tagliabue P, Zucchinelli P, et al. Phase I/II study of gemcitabine in association with vinorelbine for metastatic breast cancer. Breast Cancer Res Treat. 2001;70:163-169.