Biology of circulating mRNA: Still more questions than answers?

Annals of the New York Academy of Sciences

Volumn 1075, Issue , 2006, Pages 40-49

  Fleischhacker, Michael ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Cancer; Extracellular RNA; Free circulating RNA; Plasma; Review

Indexed keywords

MESSENGER RNA; RIBOSOME RNA; TRANSFER RNA;

BLOOD LEVEL; BREAST TUMOR; COLORECTAL CANCER; COMPLEX FORMATION; CONFERENCE PAPER; FOLLICULAR LYMPHOMA; GENE OVEREXPRESSION; HUMAN; LIVER CELL CARCINOMA; LUNG TUMOR; MELANOMA; PROSTATE TUMOR; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ANALYSIS; THYROID TUMOR;

EID: 33749557625     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1368.005     Document Type: Conference Paper

References (41)

1. STROUN, M. et al. 1978. Presence of RNA in the nucleoprotein complex spontaneously released by human lymphocytes and frog auricles in culture. Cancer Res. 38: 3546-3554.
2. STROUN, M. et al. 1977. Circulating nucleic acids in higher organisms. Int. Rev. Cytol. 51: 1-48.
3. KAMM, R.C. & A.G. SMITH. 1972. Nucleic acid concentrations in normal human plasma. Clin. Chem. 18: 519-522.
4. HAMILTON, T.C. et al. 1979. Ribonucleic acid in plasma from normal adults and multiple myeloma patients. Clin. Chem. 25: 1774-1779.
5. REDDI, K.K. et al. 1976. Elevated serum ribonuclease in patients with pancreatic cancer. Proc. Natl. Acad. Sci. USA 73: 2308-2310.
6. RIEBER, M. et al. 1974. An "external" RNA removable from mammalian cells by mild proteolysis. Proc. Natl. Acad. Sci. USA 71: 4960-4964.
7. JUCKETT, D.A. et al. 1982. Actions of cis-diamminedichloroplatinum on cell surface nucleic acids in cancer cells as determined by cell electrophoresis techniques. Cancer Res. 42: 3565-3573.
8. CARR, J.M. et al. 1985. Circulating membrane vesicles in leukemic blood. Cancer Res. 45: 5944-5951.
9. ROSI, A. et al. 1988. RNA-lipid complexes released from the plasma membrane of human colon carcinoma cells. Cancer Lett. 39: 153-160.
10. CECCARINI, M. et al. Biochemical and NMR studies on structure and release conditions of RNA-containing vesicles shed by human colon adenocarcinoma cells. Int. J. Cancer 44: 714-721.
11. BARZ, D. et al. 1985. Characterization of cellular and extracellular plasma membrane vesicles from a non-metastasizing lymphoma (Eb) and its metastasizing variant (ESb). Biochem. Biophys. Acta 814: 77-84.
12. HALICKA, H.D. et al. 2000. Segregation of RNA and separate packaging of DNA and RNA in apoptotic bodies during apoptosis. Exp. Cell Res. 260: 248-256.
13. HASSELMANN, D.O. et al. 2001. Extracellular tyrosinase mRNA within apoptotic bodies is protected from degradation in human serum. Clin. Chem. 47: 1488-1489.
14. KOMEDA, T. et al. 1995. Sensitive detection of circulating hepatocellular carcinoma cells in peripheral venous blood. Cancer 75: 2214-2219.
15. NG, E.K. et al. 2002. Presence of filterable and nonfilterable mRNA in the plasma of cancer patients and healthy individuals. Clin. Chem. 48: 1212-1217.
16. JOHNSTONE, R.M. 2005. Revisiting the road to the discovery of exosomes. Blood Cells Mol. Dis. 34: 214-219.
17. GALAND, P. et al. 1966. Uptake of exogenous ribonucleic acid by ascites tumor cells. I. Autoradiographic and chromatographic studies. Exp. Cell Res. 43: 381-390.
18. GALAND, P. et al. 1966. Uptake of exogenous ribonucleic acid by ascites tumor cells. II. Relations between RNA uptake and the cellular metabolism. Exp. Cell Res. 43: 391-397.
19. KOLODNY, G.M. 1971. Evidence for transfer of macromolecular RNA between mammalian cells in culture. Exp. Cell Res. 65: 313-324.
20. KOLODNY, G.M. et al. 1972. Secretion of RNA by normal and transformed cells. Exp. Cell Res. 73: 65-72.
21. WIECZOREK, A.J. et al. 1987. Diagnostic and prognostic value of RNA-proteolipid in sera of patients with malignant disorders following therapy: first clinical evaluation of a novel tumor marker. Cancer Res. 47: 6407-6412.
22. WIECZOREK, A.J. 1984. RNA-proteoglycolipid from melanoblastoma serum transforms human bone-marrow reticulum cells. Yale J. Biol. 57: 432A.
23. MITSUHASHI, S. et al. 1978. Ribonucleic acid in the immune response. Mol. Cell. Biochem. 20: 131-147.
24. KOPRESKI, M.S. et al. 1999. Detection of tumor messenger RNA in the serum of patients with malignant melanoma. Clin. Cancer Res. 5: 1961-1965.
25. HASSELMANN, D.O. et al. 2001. Detection of tumor-associated circulating mRNA in serum, plasma and blood cells from patients with disseminated malignant melanoma. Oncol. Rep. 8: 115-118.
26. DASI, F. et al. 2001. Real-time quantification in plasma of human telomerase reverse transcriptase (hTERT) mRNA: a simple blood test to monitor disease in cancer patients. Lab. Invest. 81: 767-769.
27. KOPRESKI, M.S. et al. 2001. Circulating RNA as a tumor marker: detection of 5T4 mRNA in breast and lung cancer patient serum. Ann. N. Y. Acad. Sci. 945: 172-178.
28. GAL, S. et al. 2001. Detection of mammaglobin mRNA in the plasma of breast cancer patients. Ann. N. Y. Acad. Sci. 945: 192-194.
29. SILVA, J.M. et al. 2001. Detection of epithelial messenger RNA in the plasma of breast cancer patients is associated with poor prognosis tumor characteristics. Clin. Cancer Res. 7: 2821-2825.
30. CHEN, X.Q. et al. 2000. Telomerase RNA as a detection marker in the serum of breast cancer patients. Clin. Cancer Res. 6: 3823-3826.
31. MIURA, N. et al. 2003. Sensitive detection of human telomerase reverse transcriptase mRNA in the serum of patients with hepatocellular carcinoma. Oncology 64: 430-434.
32. SILVA, J.M. et al. 2002. Detection of epithelial tumour RNA in the plasma of colon cancer patients is associated with advanced stages and circulating tumour cells. Gut 50: 530-534.
33. WONG, S.C. et al. 2004. Quantification of plasma beta-catenin mRNA in colorectal cancer and adenoma patients. Clin. Cancer Res. 10: 1613-1617.
34. LLEDO, S.M. et al. 2004. Real time quantification in plasma of human telomerase reverse transcriptase (hTERT) mRNA in patients with colorectal cancer. Colorectal Dis. 6: 236-242.
35. NOVAKOVIC, S. et al. 2004. Detection of telomerase RNA in the plasma of patients with breast cancer, malignant melanoma or thyroid cancer. Oncol. Rep. 11: 245-252.
36. PAPADOPOULOU, E. et al. 2004. Cell-free DNA and RNA in plasma as a new molecular marker for prostate cancer. Oncol. Res. 14: 439-445.
37. FLEISCHHACKER, M. et al. 2001. Detection of amplifiable messenger RNA in the serum of patients with lung cancer. Ann. N. Y. Acad. Sci. 945: 179-188.
38. SUEOKA, E. et al. 2005. Detection of plasma hnRNP B1 mRNA, a new cancer biomarker, in lung cancer patients by quantitative real-time polymerase chain reaction. Lung Cancer 48: 77-83.
39. SCHMIDT, B. et al. 2004. Detection of cell-free nucleic acids in bronchial lavage fluid supernatants from patients with lung cancer. Eur. J. Cancer 40: 452-460.
40. LAKTIONOV, P.P. et al. 2004. Extracellular circulating nucleic acids in human plasma in health and disease. Nucleosides Nucleotides Nucleic Acids 23: 879-883.
41. SCHMIDT, B. et al. 2005. Quantification of free RNA in serum and bronchial lavage: a new diagnostic tool in lung cancer detection? Lung Cancer 48: 145-147.