Dose-dependent effects of oral dronedarone on the circadian variation of RR and QT intervals in healthy subjects: Implications for antiarrhythmic actions

Journal of Cardiovascular Pharmacology and Therapeutics

Volumn 11, Issue 3, 2006, Pages 184-190

  Wadhani, Nitin ^a   Sarma, Jonnalagedda S M ^a   Singh, Bramah N ^a,c   Radzik, David ^b   Gaud, Christine ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SANOFI   (France)

^c VA GREATER LOS ANGELES HEALTHCARE SYSTEM   (United States)

Author keywords

Antiarrhythmic agent; Dronedarone; QT circadian rhythm

Indexed keywords

AMIODARONE; DRONEDARONE; IODINE; PLACEBO;

ADRENERGIC ACTIVITY; ANTIARRHYTHMIC ACTIVITY; ARTICLE; CIRCADIAN RHYTHM; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; HEART RATE; HEART REPOLARIZATION; HUMAN; HUMAN EXPERIMENT; NORMAL HUMAN; PRIORITY JOURNAL; QT INTERVAL; RANDOMIZED CONTROLLED TRIAL; RR INTERVAL;

ADMINISTRATION, ORAL; ADULT; AMIODARONE; ANALYSIS OF VARIANCE; ANTI-ARRHYTHMIA AGENTS; CIRCADIAN RHYTHM; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; ELECTROCARDIOGRAPHY, AMBULATORY; HEART CONDUCTION SYSTEM; HEART RATE; HEART VENTRICLES; HUMANS; LINEAR MODELS; MALE; REFERENCE VALUES;

EID: 33749546706     PISSN: 10742484     EISSN: None     Source Type: Journal    
DOI: 10.1177/1074248406290678     Document Type: Article

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