Antibody repertoire development in fetal and neonatal piglets. XIII. Hybrid VH genes and the preimmune repertoire revisited

Journal of Immunology

Volumn 177, Issue 8, 2006, Pages 5459-5470

  Butler, John E ^a,b   Weber, Patrick ^a   Wertz, Nancy ^a  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN G; IMMUNOGLOBULIN M;

ANIMAL CELL; ANIMAL TISSUE; ANTIBODY RESPONSE; ARTICLE; BACTERIAL ARTIFICIAL CHROMOSOME; ENVIRONMENTAL EXPOSURE; FETUS; GENE CONVERSION; GENE DUPLICATION; GENE EXPRESSION REGULATION; GENE FREQUENCY; GENE SEQUENCE; HYBRID GENE; IMMUNE RESPONSE; NEWBORN; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SOMATIC HYPERMUTATION; SWINE; VHA GENE; VHB GENE; VHC GENE; VHE GENE;

EID: 33749531564     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.177.8.5459     Document Type: Article

References (43)

1. H III. J. Immunol. 153: 5618-5627.
2. H usage during 84 days of fetal life. J. Immunol. 161: 5070-5078.
3. Sun, J., M. Shey, and J. E. Butler. 1998. Determination of gene usage by differential polymerase chain reaction product hybridization. Anal. Biochem. 260: 71-79.
4. Butler, J. E., P. Weber, M. Sinkora, J. Sun, S. J. Ford, and R. Christenson. 2000. Antibody repertoire development in fetal and neonatal piglets. II. Characterization of heavy chain CDR3 diversity in the developing fetus. J. Immunol. 165: 6999-7011.
5. McAleer, J., P. Weber, J. Sun, and J. E. Butler. 2005. Antibody repertoire development in fetal and neonatal piglets. XI. The thymic B cell repertoire develops independently from that in blood and mesenteric lymph nodes. Immunology 114: 171-183.
6. H allotypes: implications for the generation of antibody diversity. Cell 60: 963-970.
7. Jenne, C. N., L. J. Kennedy, P. McCullagh, and J. D. Reynolds. 2003. A new model of sheep Ig diversification: shifting the emphasis toward combinatorial mechanisms and away from hypermutation. J. Immunol. 170: 3739-3750.
8. McCormack, W. T., L. W. Tjoelker, and C. B. Thompson. 1991. Avian B-cell development: generation of an immunoglobulin repertoire by gene conversion. Annu. Rev. Immunol. 9: 219-241.
9. H gene of the chicken with a high incidence in the D region. Cell 59: 171-183.
10. H gene usage and generation of antibody diversity in rabbit. Annu. Rev. Immunol. 10: 593-616.
11. H mutant rabbits. Proc. Natl. Acad. Sci. USA 92: 6961-6965.
12. Becker, R. S., and K. L. Knight. 1990. Somatic diversification of immunoglobulin heavy chain V(D)J genes: evidence for somatic gene conversion in rabbit. Cell 63: 987-997.
13. Ratcliff, M. J. H. 2006. Antibodies, immunoglobulin genes and the bursa of fabricus in chicken B cell development. Dev. Comp. Immunol. 30: 101-118.
14. Meyerhans, A., J. P. Vartanian, and S. Wain-Hobson. 1990. DNA recombination during PCR. Nucleic Acids Res. 18: 1687-1691.
15. Johnson, K. A. 1993. Conformational coupling in DNA polymerase fidelity. Annu. Rev. Biochem. 62: 685-713.
16. Sinkora, M., J. Sun, and J. E. Butler. 2000. Antibody repertoire development in fetal and neonatal piglets. V. VDJ gene chimeras resembling gene conversion products are generated at high frequency by PCR in vitro. Mol. Immunol. 37: 1025-1034.
17. Kraj, P., S. P. Rao, A. M. Glas, R. R. Hardy, E. C. B. Milner, and L. E. Silverstein. 1997. The human heavy chain Ig V region gene repertoire is biased at all stage of B cell ontogeny, including early pre-B cells. J. Immunol. 158: 5824-5837.
18. Butler, J. E., P. Weber, M. Sinkora, D. Baker, A. Schoenherr, B. Mayer, and D. Francis. 2002. Antibody repertoire development in fetal and neonatal piglets. VIII. Colonization is required for newborn piglets to make serum antibodies to T-dependent and type 2 T-independent antigens. J. Immunol. 165: 6822-6830.
19. Butler, J. E., J. Sun, P. Weber, S. P. Ford, Z. Rehakova, J. Sinkora, and K. Lager. 2001. Antibody repertoire development in fetal and nee natal piglets. IV. Switch recombination, primary in fetal thymus occurs independent of environmental antigen and is only weakly associated with repertoire diversification. J. Immunol. 167: 3239-3249.
20. Butler, J. E., N. Wertz, J. Sun, and R. Sacco. 2005. Characterization of the porcine Vβ repertoire in thymocytes versus peripheral T-cells. Immunology 114: 184-193.
21. Butler, J. E., M. Sinkora, N. Wertz, W. Holtmeier, and C. D. Lemke. 2006. Development of the neonatal B- and T-cell repertoire in swine: implications for comparative and veterinary immunology. Vet. Res. 37: 417-441.
22. Butler, J. E., J. Sun, N. Wertz, and M. Sinkora. 2006. Antibody repertoire development in swine. In Antibody Repertoire Development: Developmental and Comparative Immunology, Vol. 30. J. E. Butler, ed., pp. 199-221.
23. Butler, J. E., D. Francis, J. Freeling, P. Weber, J. Sun, K. L. Nielsen, and A. M. Krieg. 2005. Antibody repertoire development in fetal and neonatal piglets. IX. Three PAMPs act synergistically to allow germfree piglets to respond to TI-2 and TD antigens. J. Immunol. 175: 6772-6785.
24. Lemke, C. D. 2006. PRRSV infection of neonatal piglets induces immune dysregulation and modulation. Doctor of Philosophy thesis, University of Iowa, Iowa City, IA.
25. Lemke, C. D., J. S. Haynes, R. Spaete, D. Adolphson, A. Vorwald, K. Lager, and J. E. Butler. 2003. Lymphoid hyperplasia resulting in immune dysregulation is caused by PRRSV infection in pigs. J. Immunol. 172: 1916-1925.
26. D'Avirro, N., D. Truong, B. Xu, and E. Selsing. 2005. Sequence transfer between variable regions in a mouse transgene can occur by gene conversion. J. Immunol. 175: 8133-8137.
27. Winstead, C. R., S.-K., Zhai, P. Sethupathi, and K. L. Knight. 1999. Antigen induced somatic diversification of rabbit IgH genes: gene conversion and point mutation. J. Immunol. 162: 6602-6612.
28. Betz, A. G., C. Rada, C. Pannell, C. Milstein, and M. S. Heuberger. 1993. Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity and specific hot spots. Proc. Natl. Acad. Sci. USA 90: 2385-2388.
29. Mehr, R., H. Edelman, D. Sehgal, and R. Mage. 2004. Analysis of mutational lineage trees from sites of primary and secondary gene diversification in rabbits and chickens. J. Immunol. 172: 4790-4796.
30. Fais, F., F. Ghiotto, S. Hashimoto, M. Dono, A. Valetto, S. L. Allen, P. Shulman, V. P. Vineiguerra, K. Rai, M. Ferrarini, and N. Chiorazzi, 2000. Immunoglobulin V gene sequence analysis distinguish two subsets of chronic lymphocytic leukemia B cells. In The Antibodies, Vol. 6. M. Zanetti and J. D. Capra, eds. Academic Press, New York, pp. 123-150.
31. Shlomchik, M. J., A. H. Aucoin, D. Asetsky, and M. G. Weigert. 1987. Structure and function of anti-DNA autoantibodies derived from a single autoimmune mouse. Proc. Natl. Acad. Sci. USA 84: 9150-9154.
32. Reynaud, C. A., C. R. Mackay, R. G. Muller, and J. C. Weill. 1991. Somatic generation of diversity in a mammalian primary lymphoid organ: the sheep ileal Peyer's patches. Cell 64: 995-105.
33. H gene segment creates its own unique CDR-H3 repertoire and is sufficient for B cell development and immune function. J. Immunol. 175: 6624-6632.
34. Malecek, K., J. Brandman, J. E. Brodsky, Y. Ohata, M. F. Flajnik, and E. Hsu. 2005. Somatic hypermutation and junctional diversification at Ig heavy chain loci in the nurse shark. J. Immunol. 175: 8105-8115.
35. Elliott, D. E., T. Setiawan, A. Metwali, A. Blum, J. F. Urban, Jr., and J. V. Weinstock. 2004. Heligmosomoides polygyrus inhibits established colitis in IL-10-deficient mice. Eur. J. Immunol. 34: 2690-2698.
36. Liu, L. M., and G. G. MacPherson. 1993. Antigen acquisition by dendritic cells: intestinal dendritic cells acquire antigen administered orally and can prime naive T cells in vivo. J. Exp. Med. 177: 129-1307.
37. Kelsall, B. L., F. Leon, L. E. Smythies, and P. D. Smith. 2004. Antigen handling and presentation by mucosal dendritic cells and macrophages. In Mucosal Immunology, 3rd Ed. J. Mestecky, M. E. Lamm, W. Strober, J. Bienenstock, J. R. McGhee, and L. Mayer, eds. Academic Press, New York, pp. 451-485.
38. + cells accumulate in the lamina propria of the intestinal mucosal. Eur. J. Immunol. 29: 327-333.
39. Janeway, C. A., Jr., P. Travers, M. Walport, and M. J. Shlomchik, eds. 2005. Immunobiology, 6th Ed. Garland Press, New York, p. 821.
40. + peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells. J. Exp. Med. 188: 1679-1689.
41. van Es, J. H., F. H. Meylng, and T. Logtenberg. 1992. High frequency of mutated IgM molecules in the human adult blood B cell repertoire. Eur. J. Immunol. 22: 2761-2764.
42. Lefranc, M.-P., and G. Lefranc. 2001. The Immunoglobulin Facts Book. Academic Press, New York, pp. 457.
43. Sun, J., and J. E. Butler. 1996. Molecular characteristics of VDJ transcripts from a newborn piglet. Immunology 88: 331-339.