Phyllodes tumor with osteosarcomatous differentiation: A comparative immunohistochemical study between epithelial and mesenchymal cells

Tumori

Volumn 92, Issue 4, 2006, Pages 340-346

  Ribeiro Silva, Alfredo ^a   Ramalho, Leandra Náira Zambelli ^a   Zucoloto, Sérgio ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Apoptosis; Breast; Cell cycle; Immunohistochemistry; Metalloproteinase; Oncogene; Osteosarcomatous differentiation; Phyllodes tumor

Indexed keywords

ACTIN; CYCLIN D1; CYTOKERATIN; EPIDERMAL GROWTH FACTOR RECEPTOR 3; FORMALDEHYDE; GLIAL FIBRILLARY ACIDIC PROTEIN; METALLOPROTEINASE; METALLOPROTEINASE INHIBITOR; MYC PROTEIN; MYOD1 PROTEIN; PARAFFIN; PLASMINOGEN ACTIVATOR INHIBITOR; PROTEIN P21; SURVIVIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2;

ADULT; ANAMNESIS; APOPTOSIS; ARTICLE; AUTOPSY; CASE REPORT; CELL CYCLE REGULATION; CLINICAL EXAMINATION; CLINICAL FEATURE; CYSTOSARCOMA PHYLLOIDES; EPITHELIUM CELL; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MASTECTOMY; MESENCHYME CELL; METASTASIS; ONCOGENE; OSTEOSARCOMA; PROTEIN DEGRADATION; TUMOR DIFFERENTIATION;

EID: 33749530732     PISSN: 03008916     EISSN: None     Source Type: Journal    
DOI: 10.1177/030089160609200414     Document Type: Article

References (31)

1. Rosen PP: Fibroepithelial neoplasms. In: Rosen's breast pathology, Rosen PP (Ed), pp 163-200, Lippincott Williams, Philadelphia, 2001.
2. Bellocq JP, Magro G: Fibroepithelial tumors. In: Pathology and genetics of tumors of the breast and female genital organs, Tavassoli FA, Devilee P (Eds), pp 99-103, IARC Press, Lyon, 2003.
3. Vera-Sempere F, Garcia-Martinez A: Malignant phyllodes tumor of the breast with predominant chondrosarcomatous differentiation. Pathol Res Pract, 199: 841-845, 2003.
4. Isotalo PA, George RL, Walker R, Sengupta SK: Malignant phyllodes tumor with liposarcomatous differentiation. Arch Pathol Lab Med, 129: 421-422, 2005.
5. McKenzie CA, Philips J: Malignant phyllodes tumor metastatic to the lung with osteogenic differentiation diagnosed on fine needle aspiration biopsy. A case report. Acta Cytol, 46: 718-722, 2002.
6. Mukherjee P, Kalish LH, Delprado W, Crea P: Telangiectatic osteosarcomatous differentiation in a phyllodes tumour. ANZ J Surg, 74: 707-709, 2004.
7. Tsubochi H, Sato N, Kaimori M, Imai T: Osteosarcomatous differentiation in lung metastases from a malignant phyllodes tumour of the breast. J Clin Pathol, 57: 432-434, 2004.
8. Bhartia S, Kashyap P: Osteogenic pulmonary metastases originating from a phyllodes tumour of the breast with osteosarcomatous differentiation. Australas Radiol, 49: 63-65, 2005.
9. Silver SA, Tavassoli FA: Primary osteogenic sarcoma of the breast: a clinicopathologic analysis of 50 cases. Am J Surg Pathol, 22: 925-933, 1998.
10. Remadi S, Doussis-Anagnostopoulu I, Mac Gee W: Primary osteosarcoma of the breast. Pathol Res Pract, 191: 471-474, 1995.
11. Dunne B, Lee AH, Pinder SE, Bell JA, Ellis IO: An immunohistochemical study of metaplastic spindle cell carcinoma, phyllodes tumor and fibromatosis of the breast. Hum Pathol, 34: 1009-1015, 2003.
12. Chan YJ, Chen BF, Chang CL, Yang TL, Fan CC: Expression of p53 protein and Ki-67 antigen in phyllodes tumor of the breast. J Chin Med Assoc, 67: 3-8, 2004.
13. Tse GM, Lui PC, Scolyer RA, Putti TC, Kung FY, Law BK, Lau TS, Lee CS: Increased p53 protein expression in malignant mammary phyllodes tumors. Mod Pathol, 15: 734-740, 2002.
14. Sawyer EJ, Poulsom R, Hunt FT, Jeffery R, Elia G, Ellis IO, Ellis P, Tomlinson IP, Hanby AM: Malignant phyllodes tumours show stromal overexpression of c-myc and c-kit. J Pathol, 200: 59-64, 2003.
15. Tse GM, Lui PC, Scolyer RA, Putti TC, Kung FY, Law BK, Lau TS, Lee CS: Tumour angiogenesis and p53 protein expression in mammary phyllodes tumors. Mod Pathol, 16: 1007-1013, 2003.
16. Tse GM, Lui PC, Lee CS, Kung FY, Scolyer RA, Law BK, Lau TS, Karim R, Putti TC: Stromal expression of vascular endothelial growth factor correlates with tumor grade and microvessel density in mammary phyllodes tumors: a multicenter study of 185 cases. Hum Pathol, 35: 1053-1057, 2004.
17. Hicklin DJ, Ellis LM: Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol, 23: 1011-1027, 2005.
18. Piro LD: Apoptosis, Bcl-2 antisense, and cancer therapy. Oncology, 18: 5-10, 2004.
19. Kiechle FL, Zhang X: Apoptosis: biochemical aspects and clinical implications. Clin Chim Acta, 326: 27-45, 2002.
20. Ahn J, Urist M, Prives C: The Chk2 protein kinase. DNA Repair, 3: 1039-1047, 2004.
21. Townsend PA, Cutress RI, Sharp A, Brimmell M, Packham GT: BAG-1: a multifunctional regulator of cell growth and survival. Biochim Biophys Acta, 1603: 83-98, 2003.
22. Li F: Role of survivin and its splice variants in tumorigenesis. Br J Cancer, 92: 212-216, 2005.
23. Noel A, Maillard C, Rocks N, Jost M, Chabottaux V, Sounni NE, Maquoi E, Cataldo D, Foidart JM: Membrane associated proteases and their inhibitors in tumour angiogenesis. J Clin Pathol, 57: 577-584, 2004.
24. Zucker S, Cao J, Chen WT: Critical appraisal of the use of matrix metalloproteinase inhibitors in cancer treatment. Oncogene, 19: 6642-6650, 2000.
25. Djonov V, Hogger K, Sedlacek R, Laissue J, Draeger A: MMP-19: cellular localization of a novel metalloproteinase within normal breast tissue and mammary gland tumours. J Pathol, 195: 147-155, 2001.
26. Alkarain A, Jordan R, Slingerland J: p27 deregulation in breast cancer: prognostic significance and implications for therapy. J Mammary Gland Biol Neoplasia, 9: 67-80, 2004.
27. Suo Z, Nesland JM: Phyllodes tumor of the breast: EGFR family expression and relation to clinicopathological features. Ultrastruct Pathol, 24: 371-381, 2000.
28. Jamerson MH, Johnson MD, Dickson RB: Of mice and Myc: c-Myc and mammary tumorigenesis. J Mammary Gland Biol Neoplasia, 9: 27-37, 2004.
29. Weiss RH: p21Waf1/Cip1 as a therapeutic target in breast and other cancers. Cancer Cell, 4: 425-429, 2003.
30. Standal T, Borset M, Sundan A: Role of osteopontin in adhesion, migration, cell survival and bone remodeling. Exp Oncol, 26: 179-184, 2004.
31. Gonzalez-Licea A, Yardley JH, Hartmann WH: Malignant tumor of the breast with bone formation. Studies by light and electron microscopy. Cancer, 20: 1234-1247, 1967.