Cardiac toxicity from phenylpropanolamine overdose in a dog

Journal of the American Animal Hospital Association

Volumn 41, Issue 6, 2005, Pages 413-420

  Crandell, John M ^a,b   Ware, Wendy A ^a  

^a IOWA STATE UNIVERSITY   (United States)

^b Akron Veterinary Referral and Emergency Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANIS FAMILIARIS;

EID: 33749520720     PISSN: 15473317     EISSN: 15473317     Source Type: Journal    
DOI: 10.5326/0410413     Document Type: Article

References (58)

1. Hoffman BB, Lefkowitz RJ. Catecholamines and sympathomimetic drugs. In: Gillman AJ, Rall TW, Nies AS, et al., eds. Goodman and Gillman's the Pharmacological Basis of Therapeutics. 8th ed. New York: Pergamon Press, 1990:187-220.
2. Yu PH. Inhibition of monoamine oxidase activity by phenylpropanolamine, an anorectic agent. Res Commun Chem Pathol Pharmacol 1986;51:163-171.
3. Lake RC, Gallant S, Masson E, et al. Adverse drug effects attributed to phenylpropanolamine: a review of 142 case reports. Am J Med 1990;89:195-208.
4. Gunn VS, Taha SH, Liebelt EL, et al. Toxicity of over-the-counter cough and cold medications. Pediatrics 2001;108:e52.
5. Vick J, Weiss L, Ellis S. Cardiovascular studies of phenylpropanolamine. Arch Int Pharmacodyn 1994;327:13-24.
6. Conway EE, Walsh CA, Palomba AL. Supraventricular tachycardia following the administration of phenylpropanolamine in an infant. Pediatr Emerg Care 1989;5:173-174.
7. Clark JE, Simon WA. Cardiac arrhythmias after phenylpropanolamine ingestion. Drug Intell Clin Pharm 1983;17:737-738.
8. Woo OF, Benowitz NL, Bialy FW, et al. Atriventricular conduction block caused by phenylpropanolamine. JAMA 1985;253:2646-2647.
9. Pentel PR, Mikell FL, Zavoral JH. Myocardial injury after phenylpropanolamine ingestion. Br Heart J 1982;47:51-54.
10. Oosterbaan R, Burns M. Myocardial infarction associated with phenylpropanolamine. J Emerg Med 2000;18:55-59.
11. Leo PJ, Hollander JE, Shih RD, et al. Phenylpropanolamine and associated myocardial injury. Ann Emerg Med 1996;28:359-362.
12. Swenson RD, Golper TA, Bennett WM. Acute renal failure and rhabdomyolysis after ingestion of phenylpropanolamine-containing diet pills. JAMA 1982;248:1216.
13. Duffy WB, Senekjian HO, Knight TF, et al. Acute renal failure due to phenylpropanolamine. South Med J 1981;74:1548-1549.
14. Mueller SM. Neurologic complications of phenylpropanolamine use. Neurology 1983;33:650-652.
15. Dietz AJ. Amphetamine-like reactions to phenylpropanolamine. JAMA 1981;245:601-602.
16. Walker JS. Phenylpropanolamine potentiates caffeine neurotoxicity in rats. J Pharm Sci 1989;78:986-989.
17. Cantu C, Arauz A, Murillo-Bonilla LM, et al. Stroke associated with sympathomimetics contained in over-the-counter cough and cold drugs. Stroke 2003;34:1667-1672.
18. Kernan WN, Viscoli CM, Brass LM, et al. Phenylpropanolamine and the risk of hemorrhagic stroke. N Engl J Med 2000;343:1826-1832.
19. Glick R, Hoying J, Cerullo L, et al. Phenylpropanolamine: an over-the-counter drug causing central nervous system vasculitis and intracerebral hemorrhage. Neurosurgery 1987;20:969-974.
20. Mueller SM, Muller J, Asdell SM. Cerebral hemorrhage associated with phenylpropanolamine in combination with caffeine. Stroke 1984;15:119-123.
21. FDA Issues Public Health Warning on Phenylpropanolamine. 2000. Retrieved March 16, 2004, from http://www.fda.gov/bbs/topics/ANSWERS/ANS01051.html.
22. Richter KP, Ling GV. Clinical response and urethral pressure profile changes after phenylpropanolamine in dogs with primary sphincter incompetence. J Am Vet Med Assoc 1985;187:605-611.
23. White RA, Pomeroy CJ. Phenylpropanolamine: an α-adrenergic agent for the management of urinary incontinence in the bitch associated with urethral sphincter mechanism incompetence. Vet Rec 1989;125:478-480.
24. Bacon NJ, Oni O, White RA. Treatment of urethral sphincter mechanism incompetence in 11 bitches with a sustained-release formulation of phenylpropanolamine hydrochloride. Vet Rec 2002;151:373-376.
25. Kraft W, Egner B. Causes and effects of hypertension. In: Egner B, Carr A, Brown S, eds. Essential Facts of Blood Pressure in Dogs and Cats. Babenhausen: Beate Egner Vet Verlag, 2003:61-86.
26. Erhardt W, Henke J, Carr A. Causes and consequences of hypotension. In: Egner B, Carr A, Brown S, eds. Essential Facts of Blood Pressure in Dogs and Cats. Babenhausen: Beate Egner Vet Verlag, 2003:87-101.
27. Kittleson MD, Eyster GE, Knowlen GG, et al. Myocardial function in small dogs with chronic mitral regurgitation and severe congestive heart failure. J Am Vet Med Assoc 1984;184:455-459.
28. Lake RC, Zaloga G, Bray J, et al. Transient hypertension after two phenylpropanolamine diet aids and the effects of caffeine: a placebo-controlled follow-up study. JAMA 1989;86:427-432.
29. Pentel PR, Asinger RW, Benowitz NL. Propranolol antagonism of phenylpropanolamine-induced hypertension. Clin Pharmacol Ther 1985;37:488-494.
30. Morgan JP, Funderburk FR. Phenylpropanolamine and blood pressure: a review of prospective studies. Am J Clin Nutr 1992;55: 206S-210S.
31. Blackburn GL, Morgan JP, Lavin PT, et al. Determinants of the pressor effect of phenylpropanolamine in healthy subjects. JAMA 1989;261:3267-3272.
32. Pentel PR, Aaron C, Paya C. Therapeutic doses of phenylpropanolamine increase supine systolic blood pressure. Int J Obes 1985;9:115-119.
33. Plumb DC. Veterinary Drug Handbook. 4th ed. Ames: Iowa State Press, 2002:660-661.
34. 1-selective blockade. Lancet 1987;2(8559):585-589.
35. King JM, Roth L, Haschek WM. Myocardial necrosis secondary to neural lesions in domestic animals. J Am Vet Med Assoc 1982;180:144-148.
36. Samuels MA. Neurally induced cardiac damage. Neurol Clin 1993;11:273-292.
37. DeFrancesco TC, Atkins CE, Keene BW. Myocardial infarction complicating management of congestive heart failure in a dog. J Am Anim Hosp Assoc 1996;32:68-72.
38. Fregin GF, Luginbuhl H, Guarda F. Myocardial infarction in a dog with bacterial endocarditis. J Am Vet Med Assoc 1972;160: 956-963.
39. Nielsen SW, Nielsen LB. Coronary embolism in valvular bacterial endocarditis in two dogs. J Am Vet Med Assoc 1954;125:376-380.
40. Swanwick RA, Williams OJ. Fatal myocardial infarct in a greyhound. J Small Anim Pract 1982;23:451-455.
41. Weireich WE, Bisgard GE, Will JA, et al. Myocardial infarction and pulmonic stenosis in a dog. J Am Vet Med Assoc 1971;159:315-319.
42. Flickenger GL, Patterson DF. Coronary lesions associated with congenital subaortic stenosis in the dog. J Pathol Bacteriol 1967;93:133-140.
43. Kidd L, Stepien RL, Amrheiw DP. Clinical findings and coronary artery disease in dogs and cats with acute and subacute myocardial necrosis: 28 cases. J Am Anim Hosp Assoc 2000;36:199-208.
44. Bossbaly MJ, Buchanan JW, Sammarco C. Aortic body carcinoma and myocardial infarction in a Doberman pinscher. J Small Anim Pract 1993;34:638-642.
45. Driehuys S, Van Winkle TJ, Sammarco CD, et al. Myocardial infarction in dogs and cats: 37 cases (1985-1994). J Am Vet Med Assoc 1998;213:1444-1448.
46. Liu SK, Tilley LP, Tappe JP, et al. Clinical and pathologic findings in dogs with atherosclerosis: 31 cases (1970-1983). J Am Vet Med Assoc 1986;189:227-232.
47. Pinson DM. Myocardial necrosis and sudden death after an episode of aggressive behavior in a dog. J Am Vet Med Assoc 1995;211: 1371-1374.
48. Fox PR, Sisson D, Moise SN. Textbook of Canine and Feline Cardiology: Principles and Clinical Practice. 2nd ed. Philadelphia: WB Saunders, 1999:837-839.
49. Burns MJ, Dickson EW, Sivilotti ML, et al. Phentolamine reduces myocardial injury and mortality in a rat model of phenylpropanolamine poisoning. Clin Toxicol 2001;39:129-134.
50. Pentel PR, Jentzen J, Sievert J. Myocardial necrosis due to intraperitoneal administration of phenylpropanolamine in rats. Fundam Appl Toxicol 1987;9:167-172.
51. Leao PJ, Hollander JE, Shih RD, et al. Phenylpropanolamine and associated myocardial injury. Ann Emerg Med 1996;28:359-362.
52. O'Brien PJ, Landt Y, Ladenson JH. Differential reactivity of cardiac and skeletal muscle from various species in a cardiac troponin I immunoassay. Clin Chem 1997;43:2333-2338.
53. Apple FS, Murakami M, Panteghini M, et al. International survey on the use of cardiac markers. Clin Chem 201;47:587-588.
54. Ricchiuti V, Sharkey SW, Murakami MM, et al. Cardiac troponin I and T alterations in dog hearts with myocardial infarction. Am J Clin Pathol 1998;110:241-247.
55. Sleeper MM, Clifford CA, Laster LL. Cardiac troponin I in the normal dog and cat. J Vet Intern Med 2001;15:501-503.
56. Cummins B, Cummins P. Cardiac specific troponin-I release in canine experimental myocardial infarction: development of a sensitive enzyme-linked immunoassay. J Mol Cell Cardiol 1987;19:999-1010.
57. Fox PR, Sisson D, Moise SN. Textbook of Canine and Feline Cardiology: Principles and Clinical Practice. 2nd ed. Philadelphia: WB Saunders, 1999:88-89.
58. Liu S, Fox PR. Myocardial ischemia and infarction. In: Kirk RW, Bonagura JD, eds. Current Veterinary Therapy XI Small Animal Practice. Philadelphia: WB Saunders, 1992:791-795.