A prospective cohort study on orally administered heroin substitution for severely addicted opioid users

Addiction

Volumn 101, Issue 11, 2006, Pages 1631-1639

  Frick, Ulrich ^a,b   Rehm, Jürgen ^a,d,e   Kovacic, Susanne ^a,c   Ammann, Jeannine ^a   Uchtenhagen, Ambros ^a  

^a Institut fur Sucht und Gesundheitsforschung Zurich   (Switzerland)

^b CARINTHIA UNIVERSITY OF APPLIED SCIENCES   (Austria)

^c UNIVERSITY OF APPLIED SCIENCES   (Germany)

^d CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

^e UNIVERSITY OF TORONTO   (Canada)

Author keywords

Heroin substitution treatment; Open label; Opioid dependence; Oral application; Prospective cohort

Indexed keywords

DIAMORPHINE; METHADONE; MORPHINE; OPIATE;

ABDOMINAL PAIN; ADULT; ANADIPSIA; ARTICLE; BREATHING DISORDER; CLINICAL ARTICLE; CLINICAL TRIAL; COHORT ANALYSIS; CONCENTRATION LOSS; CONSTIPATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DECREASED APPETITE; DIARRHEA; DISEASE SEVERITY; DRUG DEPENDENCE TREATMENT; DRUG DOSE REGIMEN; DRUG EFFICACY; DRUG FORMULATION; DRUG SAFETY; DRUG TOLERANCE; DYSPNEA; FATIGUE; FEEDING DISORDER; FEMALE; HEADACHE; HEROIN SUBSTITUTION; HUMAN; HYPERSALIVATION; HYPOSALIVATION; IMMEDIATE RELEASE FORMULATION; INCREASED APPETITE; LIBIDO DISORDER; MALE; MEMORY DISORDER; MICTURITION DISORDER; NAUSEA; OPIATE ADDICTION; OUTPATIENT CARE; PATIENT COMPLIANCE; PROSPECTIVE STUDY; PRURITUS; SENSORY DYSFUNCTION; SIDE EFFECT; SLOW RELEASE FORMULATION; SWEATING; SWELLING; TABLET; THIRST; THORAX PAIN; TREMOR; VERTIGO; VISUAL IMPAIRMENT; VOMITING;

ADULT; COHORT STUDIES; FEMALE; HEROIN; HEROIN DEPENDENCE; HUMANS; MALE; NARCOTICS; PROSPECTIVE STUDIES; SUBSTANCE ABUSE, INTRAVENOUS; TREATMENT OUTCOME;

EID: 33749515805     PISSN: 09652140     EISSN: 13600443     Source Type: Journal    
DOI: 10.1111/j.1360-0443.2006.01569.x     Document Type: Article

References (20)

1. Degenhardt L., Hall W., Warner-Smith M., Lynsky M. Illicit drug use. In: Ezzati M., Lopez A. D., Rodgers A., Murray C. J. L., editors. Comparative quantification of health risks. Global and regional burden of disease attributable to selected major risk factors . Geneva: World Health Organization; 2004, p. 1109-75.
2. Fischer B., Rehm J., Kirst M., Casas M., Hall W., Krausz M. et al. Heroin-assisted treatment as a response to the public health problem of opiate dependence. Eur J Public Health 2002; 12: 228-34.
3. Ward J., Mattick R. P., Hall W. Methadone Maintenance Treatment and Other Opioid Replacement Therapies. Amsterdam: Harwood Academic; 1998.
4. Mattick R. P., Breen C., Kimber J., Davoli M. Methadone maintenance therapy versus no opioid replacement therapy for opioid dependence, Cochrane Database Syst Rev 2003; 2.
5. Fischer B., Rehm J., Kim G., Kirst M. Eyes wide shut? A conceptual and empirical critique of methadone maintenance treatment (MMT). Eur Addict Res 2005; 11: 1-9.
6. Amato L., Davoli M. A., Perucci C., Ferri M., Faggiano F. P., Mattick R. P. An overview of systematic reviews of the effectiveness of opiate maintenance therapies: available evidence to inform clinical practice and research. J Subst Abuse Treat 2005; 28: 321-9.
7. van den Brink W., Hendriks V., Blanken P., Koeter M., van Zwieten B., van Ree J. M. Medical prescription of heroin to treatment resistant heroin addicts: two randomised controlled trials. BMJ 2003; 327: 310.
8. Rehm J., Gschwend P., Steffen T., Gutzwiller F., Dobler-Mikola A., Uchtenhagen A. Feasibility, safety, and efficacy of injectable heroin prescription for refractory opioid addicts: a follow-up study. Lancet 2001; 385: 1417-20.
9. Rehm J., Frick U., Hartwig C., Gutzwiller F., Gschwend P., Uchtenhagen A. Mortality in heroin-assisted treatment in Switzerland 1994-2000. Drug Alcohol Depend 2005; 79: 137-43.
10. Blanken P., Hendriks V., Koeter M., Van Ree J. M., Van Den Brink W. Matching of treatment-resistant heroin-dependent patients to medical prescription of heroin or oral methadone treatment: results from two randomized controlled trials. Addiction 2005; 100: 89-95.
11. Van Den Brink W., Van Ree J. Pharmacological treatments for heroin and cocaine addiction. Eur Neuropsychopharmacol 2003; 13: 476-87.
12. Frick U., Ammann J., Kovacic S., Bürki C., Mohler M., Käser R. et al. Qualitätssicherung in der Heroin gestützten Behandlung (HegeBe) der Schweiz seit 2001: Methodische Anmerkungen zu Zielkriterien, Adjustierung des Patienten-Mix und Zentrumsvergleichen [Quality control and assurance in the heroin-assisted treatment in Switzerland after 2001: methodological remarks with respect to outcome criteria, adjusting the patient mix and comparisons between treatment centres]. Gesundheitsökonomie Qualitätsmanagement 2006; 11: 155-61.
13. Hartwig C., Lerch S., Rehm J., Gschwend P. Unerwünschte Arzneimittelwirkungen in der Heroin gestützten Behandlung (HegeBe) im Zusammenhang mit verschiedenen Applikationsformen in den Jahren 2001/2002 - Eine Auswertung der Statistik der Hegebe Meldestelle Sowie Einer Befragung Im Rahmen der Klinischen Monitors [Adverse events in heroin-assisted treatment in different forms of application of opioids in 2001 and 2002 in Switzerland]. Zürich: Institut für Suchtforschung; 2003.
14. Gerlich M., Gschwend P., Uchtenhagen A., Krämer A., Rehm J. Prevalence of hepatitis and HIV infections and vaccination rates in patients entering the heroin-assisted treatment in Switzerland between 1994 and 2002. Eur J Epidemiol in press.
15. Kalbfleisch J. D., Prentice R. L. 1980 The Statistical Analysis of Failure Time Data. New York: Wiley.
16. Daly L. Simple SAS macros for the calculation of exact binomial and Poisson confidence limits. Comput Biol Med 1992; 22: 351-61.
17. Uchtenhagen A., Gutzwiller F., Dobler-Mikola A., Steffen T., Rihs-Middel M. Prescription of Narcotics for Heroin Addicts - Main Results of the Swiss National Cohort Study . Basel: Karger Verlag; 1999, p. 134.
18. Rihs-Middel M., Jacobshagen N., Seidenberg A. Ärztliche Verschreibung von Betäubungsmitteln - Praktische Umsetzung und wichtigste Ergebnisse [Medical Prescription of Narcotics - Practical Operationalization and Key Results.] . Bern: Hans Huber.
19. Eder H., Jagsch R., Kraigher D., Primorac A., Ebner N., Fischer G. 2005 Comparative study of the effectiveness of slow-release morphine and methadone for opioid maintenance therapy. Addiction 2002; 100: 1101-9.
20. Mitchell T. B., White J. M., Somogyi A. A., Bochner F. Slow-realease oral morphine versus methadone: a crossover comparison of patient outcomes and acceptability as maintenance pharmacotherapies for opioid dependence. Addiction 2005; 100: 940-5.