Understanding the microbiology of the Aspergillus cell wall and the efficacy of caspofungin

Medical Mycology

Volumn 44, Issue SUPPL. 1, 2006, Pages 95-99

  Douglas, Cameron M ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Caspofungin; Dectin 1; Echinocandin; Glucan

Indexed keywords

1,3 BETA GLUCAN SYNTHASE; BETA GLUCAN; CASPOFUNGIN; CYTOKINE; ECHINOCANDIN;

ANTIFUNGAL ACTIVITY; ARTICLE; ASPERGILLOSIS; ASPERGILLUS FUMIGATUS; CELL WALL; CONIDIUM; CYTOKINE PRODUCTION; DISEASE MODEL; DRUG EFFICACY; FUNGAL CELL; FUNGUS CULTURE; FUNGUS GROWTH; FUNGUS HYPHAE; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; INNATE IMMUNITY; KIDNEY; MACROPHAGE; MICROBIOLOGY; NEUTROPENIA; NONHUMAN; PROTEIN BINDING; SURVIVAL;

ANIMALIA; ASPERGILLUS; ASPERGILLUS FUMIGATUS;

EID: 33749507675     PISSN: 13693786     EISSN: 14602709     Source Type: Journal    
DOI: 10.1080/13693780600981684     Document Type: Article

References (35)

1. Maertens, J and Raad, I and Petrikkos, G and (2004) Efficacy and safety of caspofungin for treatment of invasive aspergillosis in patients refractory to or intolerant of conventional antifungal therapy Clin Infect Dis, 39, pp. 1563-1571.
2. Deresinski, SC and Stevens, DA. (2003) Caspofungin Clin Infect Dis, 36, pp. 1445-1457.
3. Morrison, VA. (2005) Caspofungin: An overview Expert Rev Anti Infect Ther, 3, pp. 697-705.
4. Vazquez, JA and Sobel, JD. (2006) Anidulafungin: A novel echinocandin Clin Infect Dis, 43, pp. 215-222.
5. Chandrasekar, PH and Sobel, JD. (2006) Micafungin: A new echinocandin Clin Infect Dis, 42, pp. 1171-1178.
6. Zaas, AK and Steinbach, WJ. (2005) Micafungin: The US perspective Expert Rev Anti Infect Ther, 3, pp. 183-190.
7. Latge, JP. (1999) Aspergillus fumigatus and aspergillosis Clin Microbiol Rev, 12, pp. 310-350.
8. Beauvais, A and Bruneau, JM and Mol, PC and (2001) Glucan synthase complex of Aspergillus fumigatus J Bacteriol, 183, pp. 2273-2279.
9. Mouyna, I and Henry, C and Doering, TL and Latge, JP. (2004) Gene silencing with RNA interference in the human pathogenic fungus Aspergillus fumigatus FEMS Microbiol Lett, 237, pp. 317-324.
10. Kurtz, MB and Heath, IB and Marrinan, J and (1994) Morphological effects of lipopeptides against Aspergillus fumigatus correlate with activities against (1,3)-beta-D-glucan synthase Antimicrob Agents Chemother, 38, pp. 1480-1489.
11. Bowman, JC and Hicks, PS and Kurtz, MB and (2002) The antifungal echinocandin caspofungin acetate kills growing cells of Aspergillus fumigatus in vitro Antimicrob Agents Chemother, 46, pp. 3001-3012.
12. Bowman JC, Abruzzo GK, Flattery AM,. Efficacy of caspofungin against Aspergillus flavus, Aspergillus terreus, and Aspergillus nidulans. Antimicrob Agents Chemother in Press.
13. Petraitiene, R and Petraitis, V and Groll, AH and (2002) Antifungal efficacy of caspofungin (MK-0991) in experimental pulmonary aspergillosis in persistently neutropenic rabbits: Pharmacokinetics, drug disposition, and relationship to galactomannan antigenemia Antimicrob Agents Chemother, 46, pp. 12-23.
14. Kirkpatrick, WR and Perea, S and Coco, BJ and Patterson, TF. (2002) Efficacy of caspofungin alone and in combination with voriconazole in a guinea pig model of invasive aspergillosis Antimicrob Agents Chemother, 46, pp. 2564-2568.
15. Bowman, JC and Abruzzo, GK and Anderson, JW and (2001) Quantitative PCR assay to measure Aspergillus fumigatus burden in a murine model of disseminated aspergillosis: Demonstration of efficacy of caspofungin acetate Antimicrob Agents Chemother, 45, pp. 3474-3481.
16. Clemons, KV and Espiritu, M and Parmar, R and Stevens, DA. (2005) Comparative efficacies of conventional amphotericin B, liposomal amphotericin B (AmBisome), caspofungin, micafungin, and voriconazole alone and in combination against experimental murine central nervous system aspergillosis Antimicrob Agents Chemother, 49, pp. 4867-4875.
17. Barchiesi, F and Spreghini, E and Santinelli, A and (2005) Efficacy of caspofungin against Aspergillus terreus Antimicrob Agents Chemother, 49, pp. 5133-5135.
18. Sivak, O and Bartlett, K and Risovic, V and (2004) Assessing the antifungal activity and toxicity profile of amphotericin B lipid complex (ABLC; Abelcet) in combination with caspofungin in experimental systemic aspergillosis J Pharm Sci, 93, pp. 1382-1389.
19. van Vianen, W and de Marie, S and ten Kate, MT and Mathot, RA and Bakker-Woudenberg, IA. (2006) Caspofungin: Antifungal activity in vitro, pharmacokinetics, and effects on fungal load and animal survival in neutropenic rats with invasive pulmonary aspergillosis J Antimicrob Chemother, 57, pp. 732-740.
20. Singh, G and Imai, J and Clemons, KV and Stevens, DA. (2005) Efficacy of caspofungin against central nervous system Aspergillus fumigatus infection in mice determined by TaqMan PCR and CFU methods Antimicrob Agents Chemother, 49, pp. 1369-1376.
21. Wiederhold, NP and Kontoyiannis, DP and Chi, J and (2004) Pharmacodynamics of caspofungin in a murine model of invasive pulmonary aspergillosis: Evidence of concentration-dependent activity J Infect Dis, 190, pp. 1464-1471.
22. Hickey, E and Abruzzo, G and Bowman, JC and (2005) Caspofungin versus Amphotericin B treatment of Aspergillus fumigatus in kidneys of chronically immunosuppressed infected mice Therapy, 4, pp. 615-621.
23. Watabe, E and Nakai, T and Matsumoto, S and Ikeda, F and Hatano, K. (2003) Killing activity of micafungin against Aspergillus fumigatus hyphae assessed by specific fluorescent staining for cell viability Antimicrob Agents Chemother, 47, pp. 1995-1998.
24. Espinel-Ingroff, A. (1998) Comparison of In vitro activities of the new triazole SCH56592 and the echinocandins MK-0991 (L-743,872) and LY303366 against opportunistic filamentous and dimorphic fungi and yeasts J Clin Microbiol, 36, pp. 2950-2956.
25. Pfaller, MA and Marco, F and Messer, SA and Jones, RN. (1998) In vitro activity of two echinocandin derivatives, LY303366 and MK-0991 (L-743,792), against clinical isolates of Aspergillus, Fusarium, Rhizopus, and other filamentous fungi Diagn Microbiol Infect Dis, 30, pp. 251-255.
26. Abruzzo, GK and Gill, CJ and Flattery, AM and (2000) Efficacy of the echinocandin caspofungin against disseminated aspergillosis and candidiasis in cyclophosphamide-induced immunosuppressed mice Antimicrob Agents Chemother, 44, pp. 2310-2318.
27. Louie, A and Deziel, M and Liu, W and (2005) Pharmacodynamics of caspofungin in a murine model of systemic candidiasis: Importance of persistence of caspofungin in tissues to understanding drug activity Antimicrob Agents Chemother, 49, pp. 5058-5068.
28. Clancy, CJ and Huang, H and Cheng, S and Derendorf, H and Nguyen, MH. (2006) Characterizing the effects of caspofungin on Candida albicans, Candida parapsilosis, and Candida glabrata isolates by simultaneous time-kill and postantifungal-effect experiments Antimicrob Agents Chemother, 50, pp. 2569-2572.
29. Chiller, T and Farrokhshad, K and Brummer, E and Stevens, DA. (2001) The interaction of human monocytes, monocyte-derived macrophages, and polymorphonuclear neutrophils with caspofungin (MK-0991), an echinocandin, for antifungal activity against Aspergillus fumigatus Diagn Microbiol Infect Dis, 39, pp. 99-103.
30. Hohl, TM and Van Epps, HL and Rivera, A and (2005) Aspergillus fumigatus triggers inflammatory responses by stage-specific beta-glucan display PLoS Pathog, 1, pp. e30.
31. Steele, C and Rapaka, RR and Metz, A and (2005) The beta-glucan receptor dectin-1 recognizes specific morphologies of Aspergillus fumigatus PLoS Pathog, 1, pp. e42.
32. Wheeler, RT and Fink, GR. (2006) A drug-sensitive genetic network masks fungi from the immune system PLoS Pathog, 2, pp. e35.
33. Kahn, JN and Hsu, MJ and Racine, F and Giacobbe, R and Motyl, M. (2006) Caspofungin susceptibility in Aspergillus and non-Aspergillus molds: inhibition of glucan synthase and reduction of beta-D-1,3 glucan levels in culture Antimicrob Agents Chemother, 50, pp. 2214-2216.
34. Betts, R and Glasmacher, A and Maertens, J and (2006) Efficacy of caspofungin against invasive Candida or invasive Aspergillus infections in neutropenic patients Cancer, 106, pp. 466-473.
35. Kartsonis, NA and Saah, AJ and Joy Lipka, C and Taylor, AF and Sable, CA. (2005) Salvage therapy with caspofungin for invasive aspergillosis: results from the caspofungin compassionate use study J Infect, 50, pp. 196-205.