Genistein suppresses development of spontaneous atopic-like dermatitis in NC/Nga mice

Journal of Nutritional Science and Vitaminology

Volumn 52, Issue 4, 2006, Pages 293-296

  Sakai, Tohru ^a,b   Kogiso, Mari ^a   Mitsuya, Kaori ^a   Komatsu, Tatushi ^b   Yamamoto, Shigeru ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b Osaka Prefecture University   (Japan)

Author keywords

Cytokine; Dermatitis; Genistein; IgE; NC Nga mice

Indexed keywords

CD3 ANTIBODY; GAMMA INTERFERON; GENISTEIN; IMMUNOGLOBULIN E; INTERLEUKIN 4; MONOCLONAL ANTIBODY CD28;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATOPIC DERMATITIS; CONTROLLED STUDY; DISEASE SEVERITY; DOSE RESPONSE; DRUG EFFECT; FEMALE; IMMUNOGLOBULIN BLOOD LEVEL; IN VITRO STUDY; MOUSE; NONHUMAN; SPLEEN CELL;

EID: 33749490447     PISSN: 03014800     EISSN: 18817742     Source Type: Journal    
DOI: 10.3177/jnsv.52.293     Document Type: Article

References (24)

1. Barnes S. 1998. Evolution of the health benefits of soy isoflavones. Proc Soc Exp Biol Med 217: 386-392.
2. Anderson JJ, Ambrose WW, Garner SC. 1998. Biphasic effects of genistein on bone tissue in the ovariectomized, lactating rat model. Proc Soc Exp Biol Med 217: 345-350.
3. Honore EK, Williams JK, Anthony MS, Clarkson TB. 1997. Soy isoflavones enhance coronary vascular reactivity in atherosclerosis female macaques. Fertil Steril 67: 148-154.
4. Potter SM, Baum JA, Teng H, Stillman RJ, Shay NF, Erdman JW Jr. 1998. Soy protein and isoflavones: their effects on blood lipids and bone density in post menopausal women. Am J Clin Nutr 68: 1375S-1379S.
5. Akiyama T, Ishida J, Nakagawa S, Ogawara H, Watanabe S, Itoh N, Shibuya M, Fukami Y. 1987. Genistein, a specific inhibitor of tyrosine-specific protein kinase. J Biol Chem 262: 5592-5595.
6. Rapaport FT, Terashima T, Tsukuda K, Kono K, Takayama T, Malinowski K. 1997. Suppression of lectin, alloantigen, and xenoantigen-induced T cell proliferation by genistein. Transplan Proc 29: 1261-1264.
7. Yellayi S, Zakroczymski MA, Selvaraj V, Valli VE, Ghanta V, Helferich WG, Cooke PS. 2003. The phytoestrogen genistein suppresses cell-mediated immunity in mice. J Endocrinol 176: 267-274.
8. Verdrengh M, Jonsson IM, Hilmdahl R, Tarkowski A. 2003. Genistein as an anti-inflammatory agent. Inflamm Res 52: 341-346.
9. Guo TL, McCay JA, Zhang LX, Brown RD, You L, Karrow NA, Germolec DR, White KL Jr. 2001. Genistein modulates immune responses and increases host resistance to B16F10 tumor in adult female B6C3F1 mice. J Nutr 131: 3251-3258.
10. Guo TL, Zhang XL, Bartolucci E, McCay JA, White KL Jr, You L. 2002. Genistein and methoxychlor modulate the activity of natural killer cells and the expression of phenotypic markers by thymocytes and splenocytes in F0 and F1 generations of Sprague-Dawley rats. Toxicology 172: 205-215.
11. Guo TL, White KL Jr, Brown RD, Delclos KB, Newbold RR, Weis C, Germolec DR, McCay JA. 2002. Genistein modulates splenic natural killer cell activity, antibody-forming cell response, and phenotypic marker expression in F0 and F1 generations of Sprague-Dawley rats. Toxicol Appl Pharmacol 181: 219-227.
12. Uehara M, Kimura C. 1993. Descendant family history of atopic dermatitis. Acta Dermatol Venereol 73: 62-63.
13. Van Bever HP. 1992. Recent advances in the pathogenesis of atopic dermatitis. Bur J Pediatr 151: 870-873.
14. Matsuda H, Watanabe N, Geba GP, Sperl J, Tsuduki M, Hiroi J, Matsumoto M, Ushio H, Saito S, Askenase PW, Ra C. 1997. Development of atopic dermatitis-like skin lesion with IgE hyperproduction in NC/Nga mice. Int Immunol 9: 461-466.
15. Matsumoto M, Ra C, Kawamoto K, Sato H, Itakura A, Sawada J, Ushio H, Suto H, Mitsuishi K, Hikasa Y, Matsuda H. 1999. IgE hyperproduction through enhanced tyrosine phosphorylation of janus kinase 3 in NC/Nga mice, a model for human atopic dermatitis. J Immunol 162: 1056-1063.
16. Li-Weber M, Krammer PH. 2003. Regulation of IL-4 gene expression by T cells and therapeutic perspectives. Nat Rev Immunol 3: 534-543.
17. Yagi R, Nagai H, Iigo Y, Akimoto T, Aral T, Kubo M. 2002. Development of atopic dermatitis-like skin lesion in STAT6-deficient NC/Nga mice. J Immunol 168: 2020-2027.
18. Takeda K, Tanaka T, Shi W, Matsumoto M, Minami M, Kashiwamura S, Nakanishi K, Yoshida N, Kishimoto T, Akira S. 1996. Essential role of Stat6 in IL-4 signaling. Nature 380: 627-630.
19. Whitten PL, Patisaul HB. 2001. Cross-species and interassay comparisons of phytoestrogen action. Environ Health Perspect 109 (Suppl 1): 5-20.
20. Setchell KD, Zimmer-Nechemias L, Cai J, Heubj JE. 1997. Exposure of infants to phyto-estrogens from soy-based infant formula. Lancet 350: 23-27.
21. Maret A, Coudert JD, Garidou L, Foucras G, Gourdy P, Krusst A, Dupont S, Chambon P, Druet P, Bayard F, Guery J-C. 2003. Estradiol enhances primary antigen-specific CD4 T cell responses and Th1 development in vivo. Essential role of estrogen receptor α expression in hematopoietic cells. Eur J Immunol 33: 512-521.
22. Karpuzoglu-Sahim E, Zhi-Jun Y, Lengi A, Sriranganathan N, Ansar Ahmed S. 2001. Effects of long-term estrogen treatment on IFN-γ, IL-2 and IL-4 gene expression and protein synthesis in spleen and thymus of normal C57BL/6 mice. Cytokine 14: 208-217.
23. Kinet JP. 1999. IgE receptor (FcRI): from physiology to pathology. Annu Rev Immunol 17: 931-972.
24. Duan W, Kuo IC, Selvarajan S, Chua KY, Bay BH, Wong WSF. 2003. Antiinflammatory effect of genistein, a tyrosine kinase inhibitor, on a Guinea pig model of asthma. Am J Respir Crit Care Med 167: 185-192.