Synthesis and antidiabetic activity of novel 2,4-thiazolidinedione derivatives containing a thiazole ring

Arzneimittel-Forschung/Drug Research

Volumn 56, Issue 9, 2006, Pages 621-625

  Bozdaǧ Dündar, Oya ^a   Ceylan Ünlüsoy, Meltem ^a   Verspohl, Eugen J ^b   Ertan, Rahmiye ^a  

^a ANKARA UNIVERSITY   (Turkey)

^b UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

2,4 Thiazolidinediones, antidiabetic activities, synthesis, thiazole derivatives; Antidiabetics

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; 3 (4 NITRO BENZYL) 5 (2,4 DICHLORO THIAZOL 5 YL METHYLENE) 2,4 THIAZOLIDINEDIONE; 3 BENZYL 5 (2 BENZYL SULFANYL 4 CHLORO THIAZOL 5 YL METHYLENE) 2,4 THIALIDINEDIONE; ALDEHYDE; BENZYL 2,4 THIAZOLIDINEDIONE DERIVATIVE; CHLOROTHIAZOLECARBALDEHYDE DERIVATIVE; THIAZOLE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; DRUG ACTIVITY; DRUG SYNTHESIS; INSULIN LIKE ACTIVITY; KNOEVENAGEL CONDENSATION; NONHUMAN; PANCREAS ISLET BETA CELL; RAT;

EID: 33749478923     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0031-1296762     Document Type: Article

References (9)

1. Reaven, G. M., Role of insulin resistance in human disease. Diabetes 37, 1595 (1988)
2. DeFronzo, R. A., Bonadonna, R. C., Ferrannini, E., Pathogenesis of NIDDM. Diabetes Care 15, 318 (1992)
3. Bradly, C., The glitazones: a new treatment for type 2 diabetes mellitus. Intensive and Critical Care Nursing 18, 189 (2002)
4. Gerich, J. E., Oral hypoglycemic agents. N. Engl. J. Med. 321, 1231 (1989)
5. Sturmvoll M., Haring H-U., Glitazones: clinical effects and molecular mechanisms. Ann. Med. 34, 217 (2002)
6. Lima M. C. A., Costa D. L. B., Goes A. J. S. et al., Synthesès et activité antimicrobienne de dérivès chlorobenzyl benzylidène imidazolidinediones et thiazolidinediones substituées. Pharmazie 47, 182 (1992)
7. Athmani S., Farhat M. F., Iddon B., Azoles. Part 9. Synthesis of derivatives of thieno [2,3-d]thiazole, 4H-pyrrolo-2,3-d]thiazole, 2H-pyrazolo[3,4-d]thiazole and isoxazole [3,4-d]thiazole from thiazolidine-2,4-dione. J. Chem. Soc. Perkin Trans. 1, 973 (1992)
8. Lo C., Shropshire E. Y., The Alkylation of 2,4-Thiazolidinedione. J. Org. Chem. 22, 999 (1957)
9. Costa D. L. B., Chantarel J., DeLima M. C. A. et al., Imidazolidinediones et thiazolidinediones substituées: synthèse, étude structurale et activité cytotoxique. J. Pharm. Belg. 50, 5 (1995)