Investigation of the multi-step dehydration reaction of theophylline monohydrate using 2-dimensional powder X-ray diffractometry

Pharmaceutical Research

Volumn 23, Issue 10, 2006, Pages 2393-2404

  Nunes, Cletus ^a,b   Mahendrasingam, Arumugam ^c   Suryanarayanan, Raj ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b BRISTOL MYERS SQUIBB   (United States)

^c KEELE UNIVERSITY   (United Kingdom)

Author keywords

Anhydrate; Dehydration; Metastable; Polymorph; Synchrotron; Theophylline monohydrate; Two dimensional; X ray diffraction

Indexed keywords

EXCIPIENT; POVIDONE; THEOPHYLLINE;

AQUEOUS SOLUTION; ARTICLE; CONCENTRATION (PARAMETERS); CRYSTALLIZATION; KINETICS; POWDER DIFFRACTION; PRIORITY JOURNAL; SOLID STATE; SYNCHROTRON RADIATION; TEMPERATURE; X RAY DIFFRACTION;

ALGORITHMS; CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHARMACEUTICAL; DESICCATION; DIFFERENTIAL THERMAL ANALYSIS; KINETICS; SYNCHROTRONS; TABLETS; THEOPHYLLINE; THERMOGRAVIMETRY; X-RAY DIFFRACTION;

EID: 33749446863     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-006-9022-5     Document Type: Article

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