The WHO analgesic ladder for cancer pain control, twenty years of use. How much pain relief does one get from using it?

Supportive Care in Cancer

Volumn 14, Issue 11, 2006, Pages 1086-1093

  Azevedo Sao Leao Ferreira, Karine ^a,b   Kimura, Miako ^a   Jacobsen Teixeira, Manoel ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b NONE   (Brazil)

Author keywords

Analgesics drugs; Cancer pain; Side effects; WHO analgesic ladder; WHO guidelines

Indexed keywords

ACETYLSALICYLIC ACID; AMITRIPTYLINE; ANALGESIC AGENT; BUPRENORPHINE; CARBAMAZEPINE; CITALOPRAM; CLONAZEPAM; CODEINE; DEXTROPROPOXYPHENE; DEXTROPROPOXYPHENE NAPSILATE; DICLOFENAC; DIHYDROCODEINE; DIPYRONE; FENTANYL; FLURBIPROFEN; IBUPROFEN; KETOBEMIDONE; KETOROLAC; METHADONE; MORPHINE; NAPROXEN; NORTRIPTYLINE; OXYCODONE; PARACETAMOL; PHENYTOIN; PIRITRAMIDE; SUFENTANIL; TILIDINE; TRAMADOL; UNINDEXED DRUG;

ANALGESIA; CANCER PAIN; CANCER PATIENT; CONSTIPATION; DATA BASE; DIZZINESS; DROWSINESS; DYSPNEA; EMBASE; HUMAN; LILACS; MEDLINE; MENTAL DISEASE; NAUSEA; NEUROLOGIC DISEASE; PRACTICE GUIDELINE; PRIORITY JOURNAL; PUBLICATION; REVIEW; SEDATION; SIDE EFFECT; SWEATING; URINARY TRACT DISEASE; VERTIGO; VOMITING; WORLD HEALTH ORGANIZATION; XEROSTOMIA;

ANALGESICS; HUMANS; NEOPLASMS; PAIN; PAIN MEASUREMENT; PROSPECTIVE STUDIES; RESEARCH DESIGN; RETROSPECTIVE STUDIES; TREATMENT OUTCOME; WORLD HEALTH ORGANIZATION;

EID: 33749384695     PISSN: 09414355     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00520-006-0086-x     Document Type: Review

References (59)

1. Barrett B, Brown D, Mundt M, Brown R (2005) Sufficiently important difference: expanding the framework of clinical significance. Med Decis Mak 25(3):250-261
2. Beer TM, Eilers KM, Garzotto M, Hsieh YC, Mori M (2004) Quality of life and pain relief during treatment with calcitriol and docetaxel in symptomatic metastatic androgen-independent prostate carcinoma. Cancer 100(4):758-763
3. Brasil. Ministério da Saúde. Instituto Nacional do Câncer-INCA (1997) O alívio da dor do câncer: com um guia para a disponibilidade de opiáceos. INCA, Rio de Janeiro
4. Brasil. Ministério da Saúde. Instituto Nacional do Câncer-INCA (2001) Cuidados Paliativos oncológicos: controle da dor. INCA, Rio de Janeiro
5. Burton AW, Cleeland CS (2001) Cancer pain: progress since the WHO Guidelines. Pain Practice 1(3):236-242
6. Cleeland CS, Gonin R, Hotfield AK, Edmonson JH, Blum RH, Stewart JA, Pandya KJ (1994) Pain and its treatment in outpatients with metastatic cancer. N Eng J Med 330(9):592-596
7. Cook DJ, Guyatt GH, Laupacis A, Sackett DL (1992) Rules of evidence and clinical recommendations on the use of antithrombotic agents. Chest 102(4 Suppl):305S-311S
8. Coyne PJ (2003) When the World Health Organization analgesic therapies ladder fails: the role of invasive analgesic therapies. Oncol Nurs Forum 30(5):777-783
9. de Wit R, van Dam F, Abu-Saad HH, Loonstra S, Zandbelt L, van Buuren A, van der Heijden K, Leenhouts G (1999) Empirical comparison of commonly used measures to evaluate pain treatment in cancer patients with chronic pain. J Clin Oncol 17(4):1280
10. Di Maio M, Gridelli C, Gallo C, Manzione L, Brancaccio L, Barbera S, Robbiati SF, Ianniello GP, Ferraù F, Piazza E, Frontini L, Rosetti F, Carrozza F, Bearz A, Spatafora M, Adamo V, Isa L, Iaffaiol RVi, E Salvo Di, Perrone F (2004) Prevalence and management of pain in Italian patients with advanced non-small-cell lung cancer. Br J Cancer 90:2288-2296
11. Ferlay J, Bray F, Pisani P, Parkin DM (2004). GLOBOCAN 2002: Cancer Incidence, Mortality and Prevalence Worldwide, Version 2.0. IARC CancerBase No. 5. Lyon, IARCPress. Limited version available from: URL: http://www-depdb.iarc. fr/globocan2002.htm
12. Fernández R, Rey R (1995) Evaluación de la escala analgésica de la OMS en el hagar de la Liga Chilena contra el cáncer. Dolor 3(13):6-7
13. Goisis A, Gorini M, Ratti R, Luliri P (1989) Application of a WHO protocol on medical therapy for oncologic pain in an internal medicine hospital. Tumori 75(5):470-472
14. Grond S, Zech D, Schug SA, Lynch J, Lehmann KA (1991a) The importance of non-opioid analgesic for cancer pain relief according the guidelines of The World Health Organization. Int J Clin Pharmacol Res 11(6):253-260
15. Grond S, Zech D, Schug SA, Lynch J, Lehmann KA (1991b) Validation of World Health Organization guidelines for cancer pain relief the last days and hours of life. J Pain Symptom Manage 6(7):411-422
16. Grond S, Zech D, Lynch J, Diefenbach C, Schug SA, Lehmann KA (1993) Validation of World Health Organization guidelines for pain relief in head and neck cancer. A prospective study. Ann Otol Rhinol Laryngol 102(5):342-348
17. Grond S, Radbruch L, Meuser T, Sabatowski R, Loick G, Lehmann KA (1999) Assessment and treatment of neuropathic cancer pain following WHO guidelines. Pain 79(1):15-20
18. Hwang WS, Tsai YF, Chang HC, Liu IP, Huang CT (2002) A prospective study of pain treatment for patients with advanced cancer who receive hospice home care. Zhonghua Yi Xue Za Zhi (Taipei) 65(7):331-335
19. Jadad AR, Browman GP (1995) The WHO analgesic ladder for cancer pain management: stepping up the quality of its evaluation. JAMA 274(23):1870-1873
20. Jadad AR, Browman GP (1996) Pain control and the World Health Organization Analgesic Ladder. JAMA 275(11):836
21. Katz N (2002) The impact of pain management on quality of life. J Pain Symptom Manage 24(1 Suppl):S38-S47
22. Larue F, Colleau SM, Fontaine A, Brasseur L (1995) Oncologists and primary care physicians' attitudes toward pain control and morphine prescribing in France. Cancer 76(11):2375-2382
23. Liu LM, Yu EX (1989) Treatment of pain according to syndrome differentiation in 169 cases of liver cancer. J Tradit Chin Med 9(4):277-280
24. Mantadakis E, Panagiotidis C, Delakas D, Samonis G (2003) Symptomatic relief of patients with advanced bladder carcinoma after regional intra-arterial chemotherapy. Anticancer Res 23(6D):5143-5147
25. Marinangeli F, Ciccozzi A, Leonardis M, Aloisio L, Mazzei A, Paladini A, Porzio G, Marchetti P, Varrassi G (2004) Use of strong opioids in advanced cancer pain: a randomized trial. J Pain Symptom Manage 27(5):409-416
26. Mercadante S, Maddaloni S, Roccella S, Salvaggi L (1992) Predictive factors in advanced cancer pain treatment only by analgesic. Pain 50(2):151-155
27. Mercadante S (1999) Pain treatment and outcomes for patients with advance cancer who received follow-up care at home. Cancer 85(8):1849-1858
28. Mercadante S, Arcuri E, Tirelli W, Villari P, Casuccio A (2002) Amitriptyline in neuropathic cancer pain in patients on morphine therapy: a randomized placebo-controlled, double-blind crossover study. Tumori 88(3):239-242
29. Meuser T, Pietruck C, Radbruch L, Stute P, Lehmann KA, Grond S (2001) Symptoms during cancer pain treatment following WHO guidelines: a longitudinal follow-up study of symptom prevalence severity and etiology. Pain 93:247-257
30. Miguel R (2000) Interventional treatment of cancer pain: the fourth step in the World Health Organization Analgesic Ladder? Cancer Control 7(2):149-156
31. Morgan AE, Lindley CM, Berry JI (1994) Assessment of pain and patterns of analgesic use in hospice patients. Am J Hospice Palliat Care 11(1):13-19, 22-25
32. Petrylak DP, Tangen CM, Hussain MH, Lara PN Jr, Jones JA, Taplin ME, Burch PA, Berry D, Moinpour C, Kohli M, Benson MC, Small EJ, Raghavan D, Crawford ED (2004) Docetaxel and estramustine compared with mitoxantrone and prednisone for advanced refractory prostate cancer. N Engl J Med 351(15):1513-1520
33. Reidenberg MM (1996) Pain control and the World Health Organization analgesic ladder. JAMA 275(11):835
34. Rustoen T, Fossa SD, Skarstein J, Moum T (2003) The impact of demographic and disease-specific variables on pain in cancer patients. J Pain Symptom Manage 26(2):696-704
35. Sabatowski R, Arens ER, Waap I, Radbruch L (2001) Cancer pain management in Germany - results and analysis of a questionnaire. Schmerz 15(4):241-247
36. Samek M, Zech D, Grond S (1990) Pain relieving therapy for 57 patients with malignancies in the head and neck area. Dtsch Zahnarztl Z 45(1):49-51
37. Schneider M, Eichner C (1994) Pain therapy of tumor patients with special reference to tumors of the gastrointestinal tract. WHO staged schedule versus para-spinal analgesic techniques. Chirurg 65(6):551-555
38. Schug SA, Zech D, Dorr U (1990) Cancer pain management according to WHO analgesic guidelines. J Pain Symptom Manage 5(1):27-32
39. Shvartzman P, Friger M, Shani A, Barak F, Yoram C, Singer Y (2003) Pain control in ambulatory cancer patients - can we do better? J Pain Symptom Manage 26(2):716-722
40. Sloan J, Symonds T, Vargas-Chanes D, Fridley B (2003) Practical guidelines for assessing the clinical significance of health-related quality of life changes within clinical trials. Drug Information J 37:23-31
41. Strömgren AS, Groenvold M, Petersen MA, Goldschmidt D, Pedersen L, Spile M, Irming-Pedersen G, Sjorgren P (2004) Pain characteristics and treatment outcome for advanced cancer patients during the first week of specialized palliative care. J Pain Symptom Manage 27(2):104-113
42. Stute P, Soukup J, Menzel M, Sabatowski R, Grond S (2003) Analysis and treatment of different types of neuropathic cancer pain. J Pain Symptom Manage 26(6):1123-1131
43. Symonds T, Berzon R, Marquis P, Rummans TA (2002) Clinical Significance Consensus Meeting Group. The clinical significance of quality-of-life results: practical considerations for specific audiences. Mayo Clin Proc 77(6):572-583
44. Talmi YP, Waller A, Bercovici M, Horowitz Z, Pfeffer MR, Adunski A, Kronenberg J (1997) Pain experienced by patients with terminal head and neck carcinoma. Cancer 80(6):1117-1123
45. Terwee CB, Dekker FW, Wiersinga WM, Prummel MF, Bossuyt PM (2003) On assessing responsiveness of health-related quality of life instruments: guidelines for instrument evaluation. Qual Life Res 12(4):349-362
46. Theobald DE, Kish KL, Holtsclaw E, Donaghy K, Passik SD (2002) An open-label, cross-over trial of mirtazapine (15 and 30 mg) in cancer patients with pain and other distressing symptoms. J Pain Symptom Manage 23(5):442-447
47. Twycross R, Lickiss N (1996) Pain control and the World Health Organization Analgesic Ladder. JAMA 275(11):835
48. Ventafridda V, Tamburini M, Caraceni A, De Conno F, Naldi F (1987) A validation study of the WHO method for cancer pain relief. Cancer 59(4):850-856
49. Ventafridda GV, Caraceni AT, Snanotto AM, Barletta L, De Conno F (1990a) Pain treatment in cancer of pancreas. Eur J Surg Oncol 16(1):1-6
50. Ventafridda GV, Caraceni A, Gamba A (1990b) Field-testing of th WHO guidelines for cancer pain relief. In: Foley KM, Bonica JJ, Ventafridda GV, Callaway MV (eds) Advances in pain research and therapy. Raven, New York
51. Ventafridda V, Stjernsward J (1996) Pain control and the World Health Organization Analgesic Ladder. JAMA 275(11):835-836
52. Walker VA, Hoskin PJ, Hanks GW, White ID (1988) Evaluation of WHO analgesic guidelines for cancer pain in a hospital-based palliative care unit. J Pain Symptom Manage 3(3):145-149
53. Ward SE, Goldberg N, Miller-McCauley V, Mueller C, Nolan A, Pawlik-Plank D, Robbins A, Stormoen D, Weissman DE (1993) Patient-related barriers to management of cancer pain. Pain 52(3):319-324, Mar
54. Wenk R, Diaz C, Echeverria M, Aparicio A, Bertucelli N, Courtalon M, De Felipe M, Ocariz J, Clerici M, Pacini T (1991) Argentina's WHO Cancer Pain Relief Program: a patient care model. J Pain Symptom Manage 6(1):40-43
55. World health Organization (1987) Alivio del dolor en el cancer. World Health Organization, Geneva Switzerland
56. World Health Organization (1996) Cancer pain relief: with guide to opioid availability, 2nd edn. World Health Organization, Geneva Switzerland
57. Wyrwich KW, Bullinger M, Aaronson N, Hays RD, Patrick DL, Symonds T (2005) The Clinical Significance Consensus Meeting Group. Estimating clinically significant differences in quality of life outcomes. Qual Life Res 14(2):285-295
58. Yun YH, Heo DS, Lee IG, Jeong HS, Kim HJ, Kim S-Y, Kim YH, Ro YJ, Yoon SS, Lee KH, Huh BY (2003) Multicenter study of pain and its management in patients with advanced cancer in Korea. J Pain Symptom Manage 25(5):430-437
59. Zech DF, Grond S, Lynch J, Hertel D, Lehmann KA (1995) Validation of World Health Organization Guidelines for cancer pain relief: a 10-year prospective study. Pain 63(1):65-76