Pharmacokinetic/pharmacodynamic insulin-glucose analysis for differentiation of beta-cell function: An 18 month follow-up study in pre-pubertal lean and obese children

Biopharmaceutics and Drug Disposition

Volumn 27, Issue 6, 2006, Pages 257-265

  Gupta, N ^a   Hoffman, R P ^b   Veng Pedersen, P ^a  

^a UNIVERSITY OF IOWA   (United States)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

Beta cells; Insulin; Pharmacodynamics; Pharmacokinetics

Indexed keywords

GLUCOSE; INSULIN;

ARTICLE; BIOLOGICAL MODEL; BLOOD SAMPLING; BODY MASS; CONTROLLED STUDY; FEMALE; FOLLOW UP; HUMAN; HUMAN EXPERIMENT; IN VIVO STUDY; INSULIN RELEASE; INTRAVENOUS GLUCOSE TOLERANCE TEST; KINETICS; LEAN BODY WEIGHT; MALE; OBESITY; PANCREAS FUNCTION; PANCREAS ISLET BETA CELL; PHARMACODYNAMICS; PLASMA HALF LIFE; PREDICTION; SCHOOL CHILD; STATISTICAL ANALYSIS;

CHILD; DATA INTERPRETATION, STATISTICAL; DIABETES MELLITUS, TYPE 2; DIETARY CARBOHYDRATES; FEMALE; FOLLOW-UP STUDIES; GLUCOSE; HUMANS; INSULIN; INSULIN-SECRETING CELLS; LONGITUDINAL STUDIES; MALE; OBESITY; STIMULATION, CHEMICAL;

EID: 33749356522     PISSN: 01422782     EISSN: 1099081X     Source Type: Journal    
DOI: 10.1002/bdd.499     Document Type: Article

References (34)

1. Zimmet P, Alberti KG, Shaw J. Global and societal implications of the diabetes epidemic. Nature 2001; 414: 782-787.
2. Yaney GC, Corkey BE. Fatty acid metabolism and insulin secretion in pancreatic beta cells. Diabetologia 2003; 46: 1297-1312.
3. Casey VA, Dwyer JT, Coleman KA, Valadian I. Body mass index from childhood to middle age: a 50-y follow-up. Am J Clin Nutr 1992; 56: 14-18.
4. Hoffman RP, Armstrong PT. Glucose effectiveness, peripheral and hepatic insulin sensitivity, in obese and lean prepubertal children. Int J Obes Relat Metab Disord 1996; 20: 521-525.
5. Rudenski AS, Hadden DR, Atkinson AB, et al. Natural history of pancreatic islet B-cell function in type 2 diabetes mellitus studied over six years by homeostasis model assessment. Diabet Med 1988; 5: 36-41.
6. DeFronzo RA. Pathogenesis of type 2 (non-insulin dependent) diabetes mellitus: a balanced overview. Diabetologia 1992; 35: 389-397.
7. Kahn SE, Prigeon RL, McCulloch DK, et al. Quantification of the relationship between insulin sensitivity and beta-cell function in human subjects. Evidence for a hyperbolic function. Diabetes 1993; 42: 1663-1672.
8. Anonymous. UK prospective diabetes study 16. Overview of 6 years' therapy of type II diabetes: a progressive disease. UK Prospective Diabetes Study Group. Diabetes 1995; 44: 1249-1258.
9. Kjems LL, Volund A, Madsbad S. Quantification of beta-cell function during IVGTT in Type II and non-diabetic subjects: assessment of insulin secretion by mathematical methods. Diabetologia 2001; 44: 1339-1348.
10. Curry DL, Bennett LL, Grodsky GM. Dynamics of insulin secretion by the perfused rat pancreas. Endocrinology 1968; 83: 572-584.
11. Ahren B, Taborsky GJ Jr. Beta-cell function and insulin secretion. In Ellenberg and Rifkin's Diabetes Mellitus: Theory and Practice, Porte D, Sherwin RS, Baron A, Ellenberg M, Rifkin H (eds). McGraw-Hill Health: New York, 2003; 43-65.
12. Taylor SI, Accili D, Imai Y. Insulin resistance or insulin deficiency. Which is the primary cause of NIDDM? Diabetes 1994; 43: 735-740.
13. Srikanta S, Ganda OP, Gleason RE, Jackson RA, Soeldner JS, Eisenbarth GS. Pre-type I diabetes. Linear loss of beta cell response to intravenous glucose. Diabetes 1984; 33: 717-720.
14. Cerasi E, Luft R. 'What is inherited - what is added' hypothesis for the pathogenesis of diabetes mellitus. Diabetes 1967; 16: 615-627.
15. Gupta N, Hoffman RP, Veng-Pedersen P. Pharmacokinetic/pharmacodynamic differentiation of pancreatic responsiveness in obese and lean children. Biopharm Drug Dispos 2005; 26: 287-294.
16. Levy J, Atkinson AB, Bell PM, McCance DR, Hadden DR. Beta-cell deterioration determines the onset and rate of progression of secondary dietary failure in type 2 diabetes mellitas: the 10-year follow-up of the Belfast Diet Study. Diabet Med 1998; 15: 290-296.
17. Hammer LD, Kraemer HC, Wilson DM, Ritter PL, Dornbusch SM. Standardized percentile curves of body-mass index for children and adolescents. Am J Dis Child 1991; 145: 259-263.
18. Matschinsky FM, Ellerman JE. Metabolism of glucose in the islets of Langerhans. J Biol Chem 1968; 243: 2730-2736.
19. Proks P, Eliasson L, Ammala C, Rorsman P. Ashcroft FM. Ca(2+)- and GTP-dependent exocytosis in mouse pancreatic beta-cells involves both common and distinct steps. Am J Physiol 1996; 496: 255-264.
20. Straub SG, Sharp GWG. The two phases of glucose-stimulated insulin secretion: mechanisms and controls. In Diabetes Mellitus: A Fundamental and Clinical Text, LeRoith D, Taylor SI, Olefsky JM (eds). Lippincott Williams & Wilkins: Philadelphia, 2004; 3-14.
21. Parsons TD, Coorssen JR, Horstmann H, Almers W. Docked granules, the exocytic burst, and the need for ATP hydrolysis in endocrine cells. Neuron 1995; 15: 1085-1096.
22. Bratanova-Tochkova TK, Cheng H, Daniel S, et al. Triggering and augmentation mechanisms, granule pools, and biphasic insulin secretion. Diabetes 2002; 51(Suppl. 1): S83-S90.
23. Rorsman P, Renstrom E. Insulin granule dynamics in pancreatic beta cells. Diabetologia 2003; 46: 1029-1045.
24. Gembal M, Detimary P, Gilon P, Gao ZY, Henquin JC. Mechanisms by which glucose can control insulin release independently from its action on adenosine triphosphate-sensitive K+ channels in mouse B cells. J Clin Invest 1993; 91: 871-880.
25. Grodsky GM. An update on implications of phasic insulin secretion. In Frontiers of Insulin Secretion and Pancreatic B-Cell Research, Flatt P, Lenzen S (eds). Smith-Gordon: London, 1994; 421-430.
26. Hutchinson MF, deHoog FR. Smoothing noise data with spline functions. Num Math 1985: 47: 99-106.
27. Pedersen PV. Curve fitting and modeling in pharmacokinetics and some practical experiences with NONLIN and a new program FUNFIT. J Pharmacokinet Biopharm 1977; 5: 513-531.
28. Kahn SE, Beard JC, Schwartz MW, et al. Increased beta-cell secretory capacity as mechanism for islet adaptation to nicotinic acid-induced insulin resistance. Diabetes 1993; 38: 562-568.
29. Field JB. Extraction of insulin by liver. Annu Rev Med 1973; 24: 309-314.
30. Peiris AN, Mueller RA, Smith GA, Struve MF, Kissebah AH. Splanchnic insulin metabolism in obesity. Influence of body fat distribution. J Clin Invest 1986; 78: 1648-1657.
31. Bonora E, Zavaroni I, Bruschi F, et al. Peripheral hyperinsulinemia of simple obesity: pancreatic hypersecretion or impaired insulin metabolism? J Clin Endocrinol Metab 1984; 59: 1121-1127.
32. Karam JH, Grodsky GM, Forsham PH. Excessive insulin response to glucose in obese subjects as measured by immunochemical assay. Diabetes 1963; 12: 197-204.
33. Starr JI, Rubenstein AH. Metabolism of endogenous proinsulin and insulin in man. J Clin Endocrinol Metab 1974; 38: 305-308.
34. Kautzky-Willer A, Pacini G, Ludvik B, Schernthaner G, Prager R. Beta-cell hypersecretion and not reduced hepatic insulin extraction is the main cause of hyperinsulinemia in obese nondiabetic subjects. Metabolism 1992; 41: 1304-1312.