Synthesis of bicyclic molecular scaffolds (BTAa): An investigation towards new selective MMP-12 inhibitors

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 22, 2006, Pages 7392-7403

  Mannino, Claudia ^a   Nievo, Marco ^a   Machetti, Fabrizio ^c   Papakyriakou, Athanasios ^a   Calderone, Vito ^a   Fragai, Marco ^a   Guarna, Antonio ^a,b  

^a UNIVERSITY OF FLORENCE   (Italy)

^b Synthesis and Study of Biologically Active Heterocycles   (Italy)

^c CNR   (Italy)

Author keywords

BTAa; Inhibitors; Metalloproteinases; NMR spectroscopy

Indexed keywords

3 AZA 6,8 DIOXA BICYCLO[3.2.1]OCTANE 3,7 DICARBOXYLIC ACID 7 [(BIPHENYL 4 YLMETHYL)AMIDE] 3 HYDROXYAMIDE; 3 BIPHENYL 4 YLMETHYL 2 OXO 3 AZA 6,8 DIOXA BICYCLO[3.2.1]OCTANE 7 CARBOXYLIC ACID; 3 BIPHENYL 4 YLMETHYL 2 OXO 3 AZA 6,8 DIOXA BICYCLO[3.2.1]OCTANE 7 CARBOXYLIC ACID HYDROXYAMIDE; 3 BIPHENYL 4 YLMETHYL 3 AZA 6,8 DIOXA BICYCLO[3.2.1]OCTANE 7 CARBOXYLIC ACID; 3 BIPHENYL 4 YLMETHYL 3 AZA 6,8 DIOXA BICYCLO[3.2.1]OCTANE 7 CARBOXYLIC ACID HYDROXYAMIDE; ACETOHYDROXAMIC ACID; CARBOXYL GROUP; HYDROXYUREA; MACROPHAGE ELASTASE; MATRIX METALLOPROTEINASE INHIBITOR; OCTANE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DRUG BINDING; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; IC 50; NUCLEAR MAGNETIC RESONANCE IMAGING; STRUCTURE ACTIVITY RELATION; X RAY ANALYSIS;

BICYCLO COMPOUNDS, HETEROCYCLIC; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HUMANS; MATRIX METALLOPROTEINASE 12; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33749351379     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.07.028     Document Type: Article

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