Effect of Acorus gramineus and its active component α-asarone on apoptosis of hippocampal neurons in epileptic young rats

Chinese Traditional and Herbal Drugs

Volumn 37, Issue 8, 2006, Pages 1196-1199

  Yang, Li Bin ^a   Li, Shu Lei ^b   Huang, Yan Zhi ^c   Wang, Yu Hong ^d   Liang, Jian Min ^d   Zhang, Shu Qin ^d  

^a THE FIRST HOSPITAL OF JILIN UNIVERSITY   (China)

^b JILIN UNIVERSITY   (China)

^c Changchun Central Hospital   (China)

^d HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

asarone; Acorus gramineus Soland; Apoptosis; Epilepsy; Phenobarbital sodium

Indexed keywords

ACORUS GRAMINEUS EXTRACT; ALPHA ASARONE; PENTETRAZOLE; PHENOBARBITAL; PLANT EXTRACT; PROTEIN BAX; PROTEIN BCL 2; UNCLASSIFIED DRUG;

ACORUS; ACORUS GRAMINEUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; APOPTOSIS; ARTICLE; BRAIN NERVE CELL; CELL COUNT; CONTROLLED STUDY; ELECTRON MICROSCOPY; EPILEPSY; HIPPOCAMPUS; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; NICK END LABELING; NONHUMAN; PROTEIN EXPRESSION; RAT; STATISTICAL SIGNIFICANCE;

EID: 33749348235     PISSN: 02532670     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. An R Z, Yin Y R, Jin C J, et al. Relationship between programmed cell death mechanisms and neuronal necrosis induced by seizures [J]. Chin J Pediatr 2003, 41: 290-292.
2. Zhang S Q, Lin W H, Zhao L M. The observation of the apoptosis in different brain regions in epilepsy rats kinkled by electrical amygdala [J]. J Apoplexy Nerv Dis 2002, 19(4): 205-207.
3. Yang L B, Li S L, Huang Y Z, et al. Effect of Acorus gramineus and its active component α-asarone on behavior and memory function of epileptic young rats [J]. Chin Tradit Herb Drugs 2005, 36(7): 1035-1038.
4. Vourliotis M E, Riechert U, Mayer P, et al. Pentylenetetrazole (PTZ)-induced c-fos expression in the hippocampus of kindled rats is suppressed by concomitant treatment with naloxone [J]. Brain Res, 1998, 792: 299-308.
5. Lai X Y, Liang H, Zhao Y Y. Research survey of chemical component and pharmacological characteristic of acorus [J]. China J Chin Mater Med 2002, 27 (3): 161-165.
6. Fujikawa D G, Shinmei S S, Cai B. Lithium-pilocarpine-induced status epilepticus produces necrotic neurons with internucleosomal DNA fragmentation in adult rats [J]. Eur J Neurosci, 1991, 11: 1605-1614.
7. Fujikawa D G, Shinmei S S, Cai B. Kainic acid-induced seizures produce necrotic, apoptotic, neurons with internucleosomal DNA cleavage: implications for programmed cell death mechanisms [J]. Neuroscience, 2000, 98: 41-53.
8. Kuang Z S, Xie Y H, Li L, et al. Protective effect of the extract of Acrous tatarinowii Schott on neuronal apoptosis induced by cerebral ischemia-reperfusion [J]. Guangdong Med J 2002, 23(5): 459-460.
9. Sermadiras D M, Joly B R. Global ischemia can cause DNA fragmentation inducative of apoptosis in rat brain [J]. Br J Dermatol, 1997, 137: 883-889.
10. Oltvai Z N, Milliman C L, Kovsmeyer S J. Bcl-2 heterodimerizes in vivo with a conseved homolog, Bax, that accelerates programmed cell death [J]. Cell, 1993, 74: 609-619.