Adenosine receptors in the response to sepsis: What do receptor-specific knockouts tell us?

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 291, Issue 4, 2006, Pages

  Law, William R ^a  

^a UNIVERSITY OF THE SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE A2 RECEPTOR; ADENOSINE A3 RECEPTOR; ADENOSINE DEAMINASE; ADENOSINE KINASE; ADENOSINE RECEPTOR; ADENOSINE RECEPTOR BLOCKING AGENT; ADENOSINE RECEPTOR STIMULATING AGENT; CYTOKINE; G PROTEIN COUPLED RECEPTOR; TUMOR NECROSIS FACTOR;

CARDIOVASCULAR EFFECT; CECUM; DRUG INHIBITION; EDITORIAL; HEMOSTASIS; IMMUNE FUNCTION TEST; KNOCKOUT MOUSE; LIGATION; LUNG FUNCTION; METABOLISM; NERVE FUNCTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; PUNCTURE; SEPSIS; SIGNAL TRANSDUCTION;

ANIMALS; DISEASE MODELS, ANIMAL; MICE; MICE, KNOCKOUT; RECEPTORS, PURINERGIC P1; SEPSIS;

EID: 33749332700     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00412.2006     Document Type: Editorial

References (17)

1. Drury AN and Szent-György A. The physiological activity of adenine compounds with especial reference to their action upon the mammalian heart. J Surg Res 68: 213-237, 1929.
2. Adanin S, Yalovetskiy IV, Nardulli BA, Sam AD, Jonjev ZS II, and Law WR. Inhibiting adenosine deaminae modulates the systemic inflammatory response syndrome in endotoxemia and sepsis. Am J Physiol Regul Integr Comp Physiol 282: R1324-R1332, 2002.
3. Cohen ES, Law WR, Easington CR, Cruz KQ, Nardulli BA, Balk RA, Parillo JE, and Hollenberg SM. Adenosine deaminase inhibition attenuates microvascular dysfunction and improves survival in sepsis. Am J Respir Crit Care Med 166: 16-20, 2002.
4. Eppell BA, Newell AM, and Brown EJ. Adenosine receptors are expressed during differentiation of monocytes to macrophages in vitro. Implications for regulation of phagocytosis. J Immunol 143: 4141-4145, 1989.
5. Firestein GS, Boyle D, Bullough DA, Gruber HE, Sajjadi FG, Montag A, Sambol B, and Mullane KM. Protective effect of an adenosine kinase inhibitor in septic shock. J Immunol 152: 5853-5859, 1994.
6. 1 adenosine receptor knock-out mice exhibit increased mortality, renal dysfunction and hepatic injury in murine septic peritonitis. Am J Physiol Renal Physiol 289: F369-F376, 2005.
7. 2a receptor activation fails to alter cAMP or contractility: role of receptor localization. Am J Physiol Heart Circ Physiol 282: H1035-H1040, 2002.
8. Law WR, Conlon BA, and Valli VE. Therapeutic potential for transient inhibition of adenosine deaminase in systemic inflammatory response syndrome. Crit Care Med 31: 1475-1481, 2003.
9. 3 adenosine receptor activation decreases mortality, renal and hepatic injury in murine septic peritonitis. Am J Physiol Regul Integr Comp Physiol 291: R959-R969, 2006.
10. Meldrum DR, Meng X, Sheridan BC, McIntyre RC Jr, Harken AH, and Banerjee A. Tissue-specific protein kinase C isoforms differentially mediate macrophage TNF-a and IL-1b production. Shock 9: 256-260, 1998.
11. Motew SJ, Mourelatos MG, Miller RN, Ferguson JL, and Law WR. Evidence that adenosine contributes to maintenance of hepatosplanchnic blood flow during peritoneal sepsis in rats. Shock 7: 439-446, 1997.
12. Motew SJ, Sam AD, Mourelatos MG II, Sharma AC, Alden KJ, Ferguson JL, and Law WR. Adenosine receptor antagonism affects regional resting vascular resistance during rat peritoneal sepsis. J Surg Res 80: 326-332, 1998.
13. 2A receptor inactivation increases survival in polymicrobial sepsis. J Immunol 176: 5616-5626, 2006.
14. 2 receptors are inhibitory. J Immunol 145: 2235-2240, 1990.
15. Sam AD, Sharma AC II, Rice AN, Ferguson JL, and Law WR. Adenosine and nitric oxide regulate regional vascular resistance via interdependent and independent mechanisms during sepsis. Crit Care Med 28: 1931-1939, 2000.
16. Sam AD, Sharma AC II, Rice AN, Ferguson JL, and Law WR. Interdependence of adenosine and nitric oxide in hepato-splanchnic circulation during sepsis. J Surg Res 94: 61-67, 2000.
17. 2A adenosine receptor activation improves survival in mouse models of endotoxemia and sepsis. J Infect Dis 189: 1897-1904, 2004.