Molecular characterization of the hypothetical 66.3-kDa protein in mouse: Lysosomal targeting, glycosylation, processing and tissue distribution

FEBS Letters

Volumn 580, Issue 24, 2006, Pages 5747-5752

  Deuschl, Florian ^a   Kollmann, Katrin ^a   von Figura, Kurt ^a   Lübke, Torben ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

66.3 kDa protein; Lysosomal localisation; Lysosomal processing; Lysosomal storage diseases; Lysosomes; Mannose 6 phosphate

Indexed keywords

BINDING PROTEIN; MANNOSE; POLYPEPTIDE;

ANIMAL CELL; ARTICLE; EMBRYO; FIBROBLAST; GLYCOSYLATION; HEART; IMMUNOFLUORESCENCE; KIDNEY; LIVER LYSOSOME; LUNG; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEOMICS; SPLEEN; TESTIS; TISSUE DISTRIBUTION; WESTERN BLOTTING;

ANIMALS; CELL LINE, TUMOR; GLYCOPROTEINS; GLYCOSYLATION; HUMANS; LYSOSOMES; MICE; MOLECULAR WEIGHT; ORGAN SPECIFICITY; PROTEIN PROCESSING, POST-TRANSLATIONAL; SUBSTRATE SPECIFICITY;

EID: 33749322938     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2006.09.029     Document Type: Article

References (13)

1. Kollmann K., Mutenda K.E., Balleininger M., Eckermann E., von Figura K., Schmidt B., and Lübke T. Identification of novel lysosomal matrix proteins by proteome analysis. Proteomics 5 15 (2005) 3966-3978
2. Sleat D.E., Lackland H., Wang Y., Sohar I., Xiao G., Li H., and Lobel P. The human brain mannose 6-phosphate glycoproteome: a complex mixture composed of multiple isoforms of many soluble lysosomal proteins. Proteomics 5 6 (2005) 1520-1532
3. Journet A., Chapel A., Kieffer S., Roux F., and Garin J. Proteomic analysis of human lysosomes: application to monocytic and breast cancer cells. Proteomics 2 8 (2002) 1026-1040
4. Scriver C.R., Beaudet A.R., Sly W., and Valle D. The Metabolic and Molecular Bases of Inherited Disease. 8th edn. (2001), McGraw-Hill Professional, New York
5. Preusser-Kunze A., Mariappan M., Schmidt B., Gande S.L., Mutenda K., Wenzel D., von Figura K., and Dierks T. Molecular characterization of the human Calpha-formylglycine-generating enzyme. J. Biol. Chem. 280 15 (2005) 14900-14910
6. Leighton F., Poole B., Beaufay H., Baudhuin P., Coffey J.W., Fowler S., and De Duve C. The large-scale separation of peroxisomes, mitochondria, and lysosomes from the livers of rats injected with triton WR-1339. Improved isolation procedures, automated analysis, biochemical and morphological properties of fractions. J. Cell Biol. 37 2 (1968) 482-513
7. Gieselmann V., Pohlmann R., Hasilik A., and von Figura K. Biosynthesis and transport of cathepsin D in cultured human fibroblasts. J. Cell Biol. 97 1 (1983) 1-5
8. Lubke T., Marquardt T., Etzioni A., Hartmann E., von Figura K., and Korner C. Complementation cloning identifies CDG-IIc, a new type of congenital disorders of glycosylation, as a GDP-fucose transporter deficiency. Nat. Genet. 28 1 (2001) 73-76
9. Wattiaux R., Wibo M., and Baudhuin P. Effect of the injection of Triton WR 1339 on the hepatic lysosomes of the rat. Arch. Int. Physiol. Biochim. 71 (1963) 140-142
10. Sleat D.E., Wang Y., Sohar I., Lackland H., Li Y., Li H., Zheng H., and Lobel P. (2006) Identification and validation of mannose 6-phosphate glycoproteins in human plasma reveals a wide range of lysosomal and non-lysosomal proteins. Mol. Cell. Proteomics. epub ahead of print.
11. Kelley R.J., Alexander D.L., Cowan C., Balber A.E., and Bangs J.D. Molecular cloning of p67, a lysosomal membrane glycoprotein from Trypanosoma brucei. Mol. Biochem. Parasitol. 98 1 (1999) 17-28
12. Danon M.J., Oh S.J., DiMauro S., Manaligod J.R., Eastwood A., Naidu S., and Schliselfeld L.H. Lysosomal glycogen storage disease with normal acid maltase. Neurology 31 1 (1981) 51-57
13. Tanaka Y., Guhde G., Suter A., Eskelinen E.L., Hartmann D., Lullmann-Rauch R., Janssen P.M., Blanz J., von Figura K., and Saftig P. Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice. Nature 406 6798 (2000) 902-906