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Volumn 6, Issue 10, 2006, Pages 983-992

Haematopoietic stem and progenitor cell-targeted therapies for thrombocytopenia

Author keywords

Haematopoietic stem cells; Thrombocytopenia; Thrombopoietin; TPO receptor ligands

Indexed keywords

AF 13948; AMG 531; ANTINEOPLASTIC AGENT; CORTICOSTEROID; CYTOKINE RECEPTOR AGONIST; ELTROMBOPAG; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IMMUNOGLOBULIN G; INTERLEUKIN 1ALPHA; JTZ 132; LEUKEMIA INHIBITORY FACTOR; RECOMBINANT INTERLEUKIN 11; RECOMBINANT MEGAKARYOCYTE GROWTH AND DEVELOPMENT FACTOR; RECOMBINANT THROMBOPOIETIN; RHESUS D ANTIBODY; SB 394725; SB 559475; STEM CELL FACTOR; STROMAL CELL DERIVED FACTOR 1; THROMBOCYTE FACTOR 4; UNCLASSIFIED DRUG;

EID: 33749322757     PISSN: 14712598     EISSN: None     Source Type: Journal    
DOI: 10.1517/14712598.6.10.983     Document Type: Review
Times cited : (6)

References (88)
  • 1
    • 0015353514 scopus 로고
    • Thrombocytopenia. I. Incidence and aetiology
    • BOTTIGER LE, WESTERHOLM B: Thrombocytopenia. I. Incidence and aetiology. Acta Med. Scand. (1972) 191(6):535-540.
    • (1972) Acta Med. Scand. , vol.191 , Issue.6 , pp. 535-540
    • Bottiger, L.E.1    Westerholm, B.2
  • 2
    • 0029914215 scopus 로고    scopus 로고
    • The thrombocytopenia of cancer. Prospects for effective cytokine therapy
    • KAUSHANSKY K: The thrombocytopenia of cancer. Prospects for effective cytokine therapy. Hematol. Oncol. Clin. North Am. (1996) 10(2):431-455.
    • (1996) Hematol. Oncol. Clin. North Am. , vol.10 , Issue.2 , pp. 431-455
    • Kaushansky, K.1
  • 3
    • 0031797309 scopus 로고    scopus 로고
    • Thrombopoietin: Biology and potential clinical applications
    • discussion 1611-1594
    • PROW D, VADHAN-RAJ S: Thrombopoietin: biology and potential clinical applications. Oncology (Williston Park) (1998) 12(11): 1597-1604, 1607-1598; discussion 1611-1594.
    • (1998) Oncology (Williston Park) , vol.12 , Issue.11 , pp. 1597-1604
    • Prow, D.1    Vadhan-Raj, S.2
  • 4
    • 0026438429 scopus 로고
    • Complications from intra-aortic balloon counterpulsation: A review of 303 cardiac surgical patients
    • ALVAREZ JM, GATES R, ROWE D, BRADY PW: Complications from intra-aortic balloon counterpulsation: a review of 303 cardiac surgical patients. Eur. J. Cardiothorac. Surg. (1992) 6(10):530-535.
    • (1992) Eur. J. Cardiothorac. Surg. , vol.6 , Issue.10 , pp. 530-535
    • Alvarez, J.M.1    Gates, R.2    Rowe, D.3    Brady, P.W.4
  • 5
    • 0032126712 scopus 로고    scopus 로고
    • Association of thrombocytopenia with the use of intra-aortic balloon pumps
    • VONDERHEIDE RH, THADHANI R, KUTER DJ: Association of thrombocytopenia with the use of intra-aortic balloon pumps. Am. J. Med. (1998) 105(1):27-32.
    • (1998) Am. J. Med. , vol.105 , Issue.1 , pp. 27-32
    • Vonderheide, R.H.1    Thadhani, R.2    Kuter, D.J.3
  • 6
    • 0031464206 scopus 로고    scopus 로고
    • The perils of platelet transfusions
    • KRUSKALL MS: The perils of platelet transfusions. N. Engl. J. Med. (1997) 337(26):1914-1915.
    • (1997) N. Engl. J. Med. , vol.337 , Issue.26 , pp. 1914-1915
    • Kruskall, M.S.1
  • 7
    • 0034032480 scopus 로고    scopus 로고
    • Current issues with platelet transfusion in patients with cancer
    • MCCULLOUGH J: Current issues with platelet transfusion in patients with cancer. Semin. Hematol. (2000) 37(2 Suppl. 4):3-10.
    • (2000) Semin. Hematol. , vol.372 , Issue.SUPPL. 4 , pp. 3-10
    • McCullough, J.1
  • 8
    • 8944225498 scopus 로고    scopus 로고
    • Idiopathic thrombocytopenic purpura: A practice guideline developed by explicit methods for the American Society of Hematology
    • GEORGE JN, WOOLF SH, RASKOB GE et al.: Idiopathic thrombocytopenic purpura: a practice guideline developed by explicit methods for the American Society of Hematology. Blood (1996) 88(1):3-40.
    • (1996) Blood , vol.88 , Issue.1 , pp. 3-40
    • George, J.N.1    Woolf, S.H.2    Raskob, G.E.3
  • 9
    • 0025674093 scopus 로고
    • A putative truncated cytokine receptor gene transduced by the myeloproliferative leukemia virus immortalizes hematopoietic progenitors
    • SOUYRI M, VIGON I, PENCIOLELLI JF et al.: A putative truncated cytokine receptor gene transduced by the myeloproliferative leukemia virus immortalizes hematopoietic progenitors. Cell (1990) 63(6):1137-1147.
    • (1990) Cell , vol.63 , Issue.6 , pp. 1137-1147
    • Souyri, M.1    Vigon, I.2    Penciolelli, J.F.3
  • 10
    • 0026684707 scopus 로고
    • Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: Identification of a member of the hematopoietic growth factor receptor superfamily
    • VIGON I, MORNON JP, COCAULT L et al.: Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: identification of a member of the hematopoietic growth factor receptor superfamily. Proc. Natl. Acad. Sci. USA (1992) 89(12):5640-5644.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , Issue.12 , pp. 5640-5644
    • Vigon, I.1    Mornon, J.P.2    Cocault, L.3
  • 11
    • 0028332474 scopus 로고
    • Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin
    • KAUSHANSKY K, LOK S, HOLLY RD et al.: Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin. Nature (1994) 369(6481):568-571.
    • (1994) Nature , vol.369 , Issue.6481 , pp. 568-571
    • Kaushansky, K.1    Lok, S.2    Holly, R.D.3
  • 12
    • 0028199208 scopus 로고
    • Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo
    • LOK S, KAUSHANSKY K, HOLLY RD et al.: Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo. Nature (1994) 369(6481):565-568.
    • (1994) Nature , vol.369 , Issue.6481 , pp. 565-568
    • Lok, S.1    Kaushansky, K.2    Holly, R.D.3
  • 13
    • 0036530040 scopus 로고    scopus 로고
    • Development of pancytopenia with neutralizing antibodies to thrombopoietin after multicycle chemotherapy supported by megakaryocyte growth and development factor
    • BASSER RL, O'FLAHERTY E, GREEN M et al.: Development of pancytopenia with neutralizing antibodies to thrombopoietin after multicycle chemotherapy supported by megakaryocyte growth and development factor. Blood (2002) 99(7):2599-2602.
    • (2002) Blood , vol.99 , Issue.7 , pp. 2599-2602
    • Basser, R.L.1    O'Flaherty, E.2    Green, M.3
  • 14
    • 0035760892 scopus 로고    scopus 로고
    • Thrombocytopenia caused by the development of antibodies to thrombopoietin
    • LI J, YANG C, XIA Y et al.: Thrombocytopenia caused by the development of antibodies to thrombopoietin. Blood (2001) 98(12):3241-3248.
    • (2001) Blood , vol.98 , Issue.12 , pp. 3241-3248
    • Li, J.1    Yang, C.2    Xia, Y.3
  • 16
    • 33749357363 scopus 로고    scopus 로고
    • Stimulating thrombopoiesis with AMG 531 improves platelet counts in patients with immune thrombocytopenic purpura
    • In Press
    • BUSSEL JB, KUTER DJ, GEORGE JN et al.: Stimulating thrombopoiesis with AMG 531 improves platelet counts in patients with immune thrombocytopenic purpura. N. Engl. J. Med. (2006) (In Press).
    • (2006) N. Engl. J. Med.
    • Bussel, J.B.1    Kuter, D.J.2    George, J.N.3
  • 17
    • 0030773876 scopus 로고    scopus 로고
    • Peptide agonist of the thrombopoietin receptor as potent as the natural cytokine
    • CWIRLA SE, BALASUBRAMANIAN P, DUFFIN DJ et al.: Peptide agonist of the thrombopoietin receptor as potent as the natural cytokine. Science (1997) 276(5319):1696-1699.
    • (1997) Science , vol.276 , Issue.5319 , pp. 1696-1699
    • Cwirla, S.E.1    Balasubramanian, P.2    Duffin, D.J.3
  • 18
    • 0032228104 scopus 로고    scopus 로고
    • Peptide agonists of the thrombopoietin receptor
    • DOWER WJ, CWIRLA SE, BALASUBRAMANIAN P et al.: Peptide agonists of the thrombopoietin receptor. Stem Cells (1998) 16(Suppl. 2):21-29.
    • (1998) Stem Cells , vol.16 , Issue.SUPPL. 2 , pp. 21-29
    • Dower, W.J.1    Cwirla, S.E.2    Balasubramanian, P.3
  • 19
    • 19944432021 scopus 로고    scopus 로고
    • Discovery and characterization of a selective, nonpeptidyl thrombopoietin receptor agonist
    • ERICKSON-MILLER CL, DELORME E, TIAN SS et al.: Discovery and characterization of a selective, nonpeptidyl thrombopoietin receptor agonist. Exp. Hematol. (2005) 33(1):85-93.
    • (2005) Exp. Hematol. , vol.33 , Issue.1 , pp. 85-93
    • Erickson-Miller, C.L.1    Delorme, E.2    Tian, S.S.3
  • 20
    • 3042830471 scopus 로고    scopus 로고
    • Induction of megakaryocytopoiesis and thrombocytopoiesis by JTZ-132, a novel small molecule with thrombopoietin mimetic activities
    • INAGAKI K, ODA T, NAKA Y et al.: Induction of megakaryocytopoiesis and thrombocytopoiesis by JTZ-132, a novel small molecule with thrombopoietin mimetic activities. Blood (2004) 104(1):58-64.
    • (2004) Blood , vol.104 , Issue.1 , pp. 58-64
    • Inagaki, K.1    Oda, T.2    Naka, Y.3
  • 21
    • 10044296968 scopus 로고    scopus 로고
    • Pharmacodynamics and pharmacokinetics of AMG 531, a novel thrombopoietin receptor ligand
    • WANG B, NICHOL JL, SULLIVAN JT: Pharmacodynamics and pharmacokinetics of AMG 531, a novel thrombopoietin receptor ligand. Clin. Pharmacol. Ther. (2004) 76(6):628-638.
    • (2004) Clin. Pharmacol. Ther. , vol.76 , Issue.6 , pp. 628-638
    • Wang, B.1    Nichol, J.L.2    Sullivan, J.T.3
  • 22
    • 22244475160 scopus 로고    scopus 로고
    • An oral, non-peptide, small molecule throbopoietin receptor agonist increases platelet counts in healthy subjects
    • JENKINS J, NICHOLL R, WILLIAMS D et al.: An oral, non-peptide, small molecule throbopoietin receptor agonist increases platelet counts in healthy subjects. Blood (2005) 106:797a.
    • (2005) Blood , vol.106
    • Jenkins, J.1    Nicholl, R.2    Williams, D.3
  • 23
    • 0037111558 scopus 로고    scopus 로고
    • Recombinant human thrombopoietin: Basic biology and evaluation of clinical studies
    • KUTER DJ, BEGLEY CG: Recombinant human thrombopoietin: basic biology and evaluation of clinical studies. Blood (2002) 100(10):3457-3469.
    • (2002) Blood , vol.100 , Issue.10 , pp. 3457-3469
    • Kuter, D.J.1    Begley, C.G.2
  • 24
    • 0347899389 scopus 로고    scopus 로고
    • The biology of hematopoietic stem cells
    • SZILVASSY SJ: The biology of hematopoietic stem cells. Arch. Med. Res. (2003) 34(6):446-460.
    • (2003) Arch. Med. Res. , vol.34 , Issue.6 , pp. 446-460
    • Szilvassy, S.J.1
  • 25
    • 0029796643 scopus 로고    scopus 로고
    • Characterization of a bipotent erythro-megakaryocytic progenitor in human bone marrow
    • DEBILI N, COULOMBEL L, CROISILLE L et al.: Characterization of a bipotent erythro-megakaryocytic progenitor in human bone marrow. Blood (1996) 88(4):1284-1296.
    • (1996) Blood , vol.88 , Issue.4 , pp. 1284-1296
    • Debili, N.1    Coulombel, L.2    Croisille, L.3
  • 26
    • 0037422537 scopus 로고    scopus 로고
    • Characterization of mouse clonogenic megakaryocyte progenitors
    • NAKORN TN, MIYAMOTO T, WEISSMAN IL: Characterization of mouse clonogenic megakaryocyte progenitors. Proc. Natl. Acad. Sci. USA (2003) 100(1):205-210.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , Issue.1 , pp. 205-210
    • Nakorn, T.N.1    Miyamoto, T.2    Weissman, I.L.3
  • 27
    • 31044452138 scopus 로고
    • Contribution to the study of the morphology of megakaryocytes and blood platelets with Feulgens test
    • CAJANO A, POLOSA P: [Contribution to the study of the morphology of megakaryocytes and blood platelets with Feulgens test.]. Haematologica (1950) 34(10):1113-1121.
    • (1950) Haematologica , vol.34 , Issue.10 , pp. 1113-1121
    • Cajano, A.1    Polosa, P.2
  • 28
    • 3042896723 scopus 로고
    • Maturation of rat megakaryocytes studied by microspectrophotometric measurement of DNA
    • ODELL TT JR, JACKSON CW, GOSSLEE DG: Maturation of rat megakaryocytes studied by microspectrophotometric measurement of DNA. Proc. Soc. Exp. Biol. Med. (1965) 119(4):1194-1199.
    • (1965) Proc. Soc. Exp. Biol. Med. , vol.119 , Issue.4 , pp. 1194-1199
    • Odell Jr., T.T.1    Jackson, C.W.2    Gosslee, D.G.3
  • 29
    • 0034762660 scopus 로고    scopus 로고
    • Of mice and men: Comparison of the ultrastructure of megakaryocytes and platelets
    • SCHMITT A, GUICHARD J, MASSE JM, DEBILI N, CRAMER EM: Of mice and men: comparison of the ultrastructure of megakaryocytes and platelets. Exp. Hematol. (2001) 29(11):1295-1302.
    • (2001) Exp. Hematol. , vol.29 , Issue.11 , pp. 1295-1302
    • Schmitt, A.1    Guichard, J.2    Masse, J.M.3    Debili, N.4    Cramer, E.M.5
  • 31
    • 0031868521 scopus 로고    scopus 로고
    • Megakaryocyte differentiation events
    • LONG MW: Megakaryocyte differentiation events. Semin. Hematol. (1998) 35(3):192-199.
    • (1998) Semin. Hematol. , vol.35 , Issue.3 , pp. 192-199
    • Long, M.W.1
  • 32
    • 0026748342 scopus 로고
    • Growth factors affecting human thrombocytopoiesis: Potential agents for the treatment of thrombocytopenia
    • GORDON MS, HOFFMAN R: Growth factors affecting human thrombocytopoiesis: potential agents for the treatment of thrombocytopenia. Blood (1992) 80(2):302-307.
    • (1992) Blood , vol.80 , Issue.2 , pp. 302-307
    • Gordon, M.S.1    Hoffman, R.2
  • 34
    • 31044442504 scopus 로고    scopus 로고
    • Megakaryocyte biology and related disorders
    • PANG L, WEISS MJ, PONCZ M: Megakaryocyte biology and related disorders. J. Clin. Invest. (2005) 115(12):3332-3338.
    • (2005) J. Clin. Invest. , vol.115 , Issue.12 , pp. 3332-3338
    • Pang, L.1    Weiss, M.J.2    Poncz, M.3
  • 35
    • 0028961058 scopus 로고
    • Thrombopoietic effects and toxicity of interleukin-6 in patients with ovarian cancer before and after chemotherapy: A multicentric placebo-controlled, randomized Phase Ib study
    • D'HONDT V, HUMBLET Y, GUILLAUME T et al.: Thrombopoietic effects and toxicity of interleukin-6 in patients with ovarian cancer before and after chemotherapy: a multicentric placebo-controlled, randomized Phase Ib study. Blood (1995) 85(9):2347-2353.
    • (1995) Blood , vol.85 , Issue.9 , pp. 2347-2353
    • D'Hondt, V.1    Humblet, Y.2    Guillaume, T.3
  • 36
    • 15844395460 scopus 로고    scopus 로고
    • A Phase I trial of recombinant human interleukin-11 (neumega rhIL-11 growth factor) in women with breast cancer receiving chemotherapy
    • GORDON MS, MCCASKILL-STEVENS WJ, BATTIATO LA et al.: A Phase I trial of recombinant human interleukin-11 (neumega rhIL-11 growth factor) in women with breast cancer receiving chemotherapy. Blood (1996) 87(9):3615-3624.
    • (1996) Blood , vol.87 , Issue.9 , pp. 3615-3624
    • Gordon, M.S.1    McCaskill-Stevens, W.J.2    Battiato, L.A.3
  • 37
    • 0031667679 scopus 로고    scopus 로고
    • Interleukin 3 in the treatment of chemotherapy induced thrombocytopenia
    • LEONARDI V, DANOVA M, FINCATO G, PALMERI S: Interleukin 3 in the treatment of chemotherapy induced thrombocytopenia. Oncol. Rep. (1998) 5(6):1459-1464.
    • (1998) Oncol. Rep. , vol.5 , Issue.6 , pp. 1459-1464
    • Leonardi, V.1    Danova, M.2    Fincato, G.3    Palmeri, S.4
  • 38
    • 0028174971 scopus 로고
    • Effects of interleukin-1 alpha on carboplatin-induced thrombocytopenia in patients with recurrent ovarian cancer
    • VADHAN-RAJ S, KUDELKA AP, GARRISON L et al.: Effects of interleukin-1 alpha on carboplatin-induced thrombocytopenia in patients with recurrent ovarian cancer. J. Clin. Oncol. (1994) 12(4):707-714.
    • (1994) J. Clin. Oncol. , vol.12 , Issue.4 , pp. 707-714
    • Vadhan-Raj, S.1    Kudelka, A.P.2    Garrison, L.3
  • 39
    • 0030917254 scopus 로고    scopus 로고
    • Interleukin-11: Review of molecular, cell biology, and clinical use
    • DU X, WILLIAMS DA: Interleukin-11: review of molecular, cell biology, and clinical use. Blood (1997) 89(11):3897-3908.
    • (1997) Blood , vol.89 , Issue.11 , pp. 3897-3908
    • Du, X.1    Williams, D.A.2
  • 40
    • 33749318418 scopus 로고    scopus 로고
    • Genetics Institute, Inc., Cambridge, MA, USA
    • NEUMEGA: Oprelvekin [package insert]. Genetics Institute, Inc., Cambridge, MA, USA (2002).
    • (2002) Oprelvekin [Package Insert]
  • 41
    • 31044439372 scopus 로고    scopus 로고
    • The molecular mechanisms that control thrombopoiesis
    • KAUSHANSKY K: The molecular mechanisms that control thrombopoiesis. J. Clin. Invest. (2005) 115(12):3339-3347.
    • (2005) J. Clin. Invest. , vol.115 , Issue.12 , pp. 3339-3347
    • Kaushansky, K.1
  • 42
    • 0037071389 scopus 로고    scopus 로고
    • The molecular and cellular biology of thrombopoietin: The primary regulator of platelet production
    • KAUSHANSKY K, DRACHMAN JG: The molecular and cellular biology of thrombopoietin: the primary regulator of platelet production. Oncogene (2002) 21(21):3359-3367.
    • (2002) Oncogene , vol.21 , Issue.21 , pp. 3359-3367
    • Kaushansky, K.1    Drachman, J.G.2
  • 43
    • 0030048887 scopus 로고    scopus 로고
    • Thrombopoietin in thrombocytopenic mice: Evidence against regulation at the mRNA level and for a direct regulatory role of platelets
    • STOFFEL R, WIESTNER A, SKODA RC: Thrombopoietin in thrombocytopenic mice: evidence against regulation at the mRNA level and for a direct regulatory role of platelets. Blood (1996) 87(2):567-573.
    • (1996) Blood , vol.87 , Issue.2 , pp. 567-573
    • Stoffel, R.1    Wiestner, A.2    Skoda, R.C.3
  • 44
    • 0032899072 scopus 로고    scopus 로고
    • The physiological response of thrombopoietin (c-Mpl ligand) to thrombocytopenia in the rat
    • YANG C, LI YC, KUTER DJ: The physiological response of thrombopoietin (c-Mpl ligand) to thrombocytopenia in the rat. Br. J. Haematol. (1999) 105(2):478-485.
    • (1999) Br. J. Haematol. , vol.105 , Issue.2 , pp. 478-485
    • Yang, C.1    Li, Y.C.2    Kuter, D.J.3
  • 45
    • 0029865443 scopus 로고    scopus 로고
    • Regulation of thrombopoietin levels by c-mpl-mediated binding to platelets
    • FIELDER PJ, GURNEY AL, STEFANICH E et al.: Regulation of thrombopoietin levels by c-mpl-mediated binding to platelets. Blood (1996) 87(6):2154-2161.
    • (1996) Blood , vol.87 , Issue.6 , pp. 2154-2161
    • Fielder, P.J.1    Gurney, A.L.2    Stefanich, E.3
  • 46
    • 0029030356 scopus 로고
    • The reciprocal relationship of thrombopoietin (c-Mpl ligand) to changes in the platelet mass during busulfan-induced thrombocytopenia in the rabbit
    • KUTER DJ, ROSENBERG RD: The reciprocal relationship of thrombopoietin (c-Mpl ligand) to changes in the platelet mass during busulfan-induced thrombocytopenia in the rabbit. Blood (1995) 85(10):2720-2730.
    • (1995) Blood , vol.85 , Issue.10 , pp. 2720-2730
    • Kuter, D.J.1    Rosenberg, R.D.2
  • 47
    • 0028909690 scopus 로고
    • Thrombopoietin (c-mpl ligand) acts synergistically with erythropoietin, stem cell factor, and interleukin-11 to enhance murine megakaryocyte colony growth and increases megakaryocyte ploidy in vitro
    • BROUDY VC, LIN NL, KAUSHANSKY K: Thrombopoietin (c-mpl ligand) acts synergistically with erythropoietin, stem cell factor, and interleukin-11 to enhance murine megakaryocyte colony growth and increases megakaryocyte ploidy in vitro. Blood (1995) 85(7):1719-1726.
    • (1995) Blood , vol.85 , Issue.7 , pp. 1719-1726
    • Broudy, V.C.1    Lin, N.L.2    Kaushansky, K.3
  • 48
    • 0028117771 scopus 로고
    • The purification of megapoietin: A physiological regulator of megakaryocyte growth and platelet production
    • KUTER DJ, BEELER DL, ROSENBERG RD: The purification of megapoietin: a physiological regulator of megakaryocyte growth and platelet production. Proc. Natl. Acad. Sci. USA (1994) 91(23):11104-11108.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , Issue.23 , pp. 11104-11108
    • Kuter, D.J.1    Beeler, D.L.2    Rosenberg, R.D.3
  • 49
    • 0029960265 scopus 로고    scopus 로고
    • Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-Mpl
    • ALEXANDER WS, ROBERTS AW, NICOLA NA, LI R, METCALF D: Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-Mpl. Blood (1996) 87(6):2162-2170.
    • (1996) Blood , vol.87 , Issue.6 , pp. 2162-2170
    • Alexander, W.S.1    Roberts, A.W.2    Nicola, N.A.3    Li, R.4    Metcalf, D.5
  • 50
    • 0029684417 scopus 로고    scopus 로고
    • Low levels of erythroid and myeloid progenitors in thrombopoietin-and c-mpl-deficient mice
    • CARVER-MOORE K, BROXMEYER HE, LUOH SM et al.: Low levels of erythroid and myeloid progenitors in thrombopoietin-and c-mpl-deficient mice. Blood (1996) 88(3):803-808.
    • (1996) Blood , vol.88 , Issue.3 , pp. 803-808
    • Carver-Moore, K.1    Broxmeyer, H.E.2    Luoh, S.M.3
  • 52
    • 0035756684 scopus 로고    scopus 로고
    • The end is just the beginning: Megakaryocyte apoptosis and platelet release
    • LI J, KUTER DJ: The end is just the beginning: megakaryocyte apoptosis and platelet release. Int. J. Hematol. (2001) 74(4):365-374.
    • (2001) Int. J. Hematol. , vol.74 , Issue.4 , pp. 365-374
    • Li, J.1    Kuter, D.J.2
  • 53
    • 0029804163 scopus 로고    scopus 로고
    • The role of megakaryocyte growth and development factor in terminal stages of thrombopoiesis
    • CHOI ES, HOKOM MM, CHEN JL et al.: The role of megakaryocyte growth and development factor in terminal stages of thrombopoiesis. Br. J. Haematol. (1996) 95(2):227-233.
    • (1996) Br. J. Haematol. , vol.95 , Issue.2 , pp. 227-233
    • Choi, E.S.1    Hokom, M.M.2    Chen, J.L.3
  • 54
    • 0032477741 scopus 로고    scopus 로고
    • Hematopoietic stem cell deficiencies in mice lacking c-Mpl, the receptor for thrombopoietin
    • KIMURA S, ROBERTS AW, METCALF D, ALEXANDER WS: Hematopoietic stem cell deficiencies in mice lacking c-Mpl, the receptor for thrombopoietin. Proc. Natl. Acad. Sci. USA (1998) 95(3):1195-1200.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , Issue.3 , pp. 1195-1200
    • Kimura, S.1    Roberts, A.W.2    Metcalf, D.3    Alexander, W.S.4
  • 55
    • 3242665129 scopus 로고    scopus 로고
    • Thrombopoietin induces HOXA9 nuclear transport in immature hematopoietic cells: Potential mechanism by which the hormone favorably affects hematopoietic stem cells
    • KIRITO K, FOX N, KAUSHANSKY K: Thrombopoietin induces HOXA9 nuclear transport in immature hematopoietic cells: potential mechanism by which the hormone favorably affects hematopoietic stem cells. Mol. Cell. Biol. (2004) 24(15):6751-6762.
    • (2004) Mol. Cell. Biol. , vol.24 , Issue.15 , pp. 6751-6762
    • Kirito, K.1    Fox, N.2    Kaushansky, K.3
  • 56
    • 17844408765 scopus 로고    scopus 로고
    • Thrombopoietin enhances expression of vascular endothelial growth factor (VEGF) in primitive hematopoietic cells through induction of HIF-lalpha
    • KIRITO K, FOX N, KOMATSU N, KAUSHANSKY K: Thrombopoietin enhances expression of vascular endothelial growth factor (VEGF) in primitive hematopoietic cells through induction of HIF-lalpha. Blood (2005) 105(11):4258-4263.
    • (2005) Blood , vol.105 , Issue.11 , pp. 4258-4263
    • Kirito, K.1    Fox, N.2    Komatsu, N.3    Kaushansky, K.4
  • 57
    • 0028803099 scopus 로고
    • Pegylated megakaryocyte growth and development factor abrogates the lethal thrombocytopenia associated with carboplatin and irradiation in mice
    • HOKOM MM, LACEY D, KINSTLER OB et al.: Pegylated megakaryocyte growth and development factor abrogates the lethal thrombocytopenia associated with carboplatin and irradiation in mice. Blood (1995) 86(12):4486-4492.
    • (1995) Blood , vol.86 , Issue.12 , pp. 4486-4492
    • Hokom, M.M.1    Lacey, D.2    Kinstler, O.B.3
  • 58
    • 0034032956 scopus 로고    scopus 로고
    • Biologic and structural differences of thrombopoietic growth factors
    • BEGLEY CG, BASSER RL: Biologic and structural differences of thrombopoietic growth factors. Semin. Hematol. (2000) 37(2 Suppl. 4):19-27.
    • (2000) Semin. Hematol. , vol.372 , Issue.SUPPL. 4 , pp. 19-27
    • Begley, C.G.1    Basser, R.L.2
  • 59
    • 0030880201 scopus 로고    scopus 로고
    • Mechanism of action and clinical trials of Mpl ligand
    • SHERIDAN WP, KUTER DJ: Mechanism of action and clinical trials of Mpl ligand. Curr. Opin. Hematol. (1997) 4(5):312-316.
    • (1997) Curr. Opin. Hematol. , vol.4 , Issue.5 , pp. 312-316
    • Sheridan, W.P.1    Kuter, D.J.2
  • 60
    • 17944389931 scopus 로고    scopus 로고
    • Randomized, blinded, placebo-controlled Phase I trial of pegylated recombinant human megakaryocyte growth and development factor with filgrastim after dose-intensive chemotherapy in patients with advanced cancer
    • BASSER RL, RASKO JE, CLARKE K et al.: Randomized, blinded, placebo-controlled Phase I trial of pegylated recombinant human megakaryocyte growth and development factor with filgrastim after dose-intensive chemotherapy in patients with advanced cancer. Blood (1997) 89(9):3118-3128.
    • (1997) Blood , vol.89 , Issue.9 , pp. 3118-3128
    • Basser, R.L.1    Rasko, J.E.2    Clarke, K.3
  • 61
    • 10344235968 scopus 로고    scopus 로고
    • Thrombopoietic effects of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) in patients with advanced cancer
    • BASSER RL, RASKO JE, CLARKE K et al.: Thrombopoietic effects of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) in patients with advanced cancer. Lancet (1996) 348(9037):1279-1281.
    • (1996) Lancet , vol.348 , Issue.9037 , pp. 1279-1281
    • Basser, R.L.1    Rasko, J.E.2    Clarke, K.3
  • 62
    • 0033861984 scopus 로고    scopus 로고
    • Enhancement of platelet recovery after myelosuppressive chemotherapy by recombinant human megakaryocyte growth and development factor in patients with advanced cancer
    • BASSER RL, UNDERHILL C, DAVIS I et al.: Enhancement of platelet recovery after myelosuppressive chemotherapy by recombinant human megakaryocyte growth and development factor in patients with advanced cancer. J. Clin. Oncol (2000) 18(15):2852-2861.
    • (2000) J. Clin. Oncol. , vol.18 , Issue.15 , pp. 2852-2861
    • Basser, R.L.1    Underhill, C.2    Davis, I.3
  • 63
    • 0031049879 scopus 로고    scopus 로고
    • Effects of polyethylene glycol-conjugated recombinant human megakaryocyte growth and development factor on platelet counts after chemotherapy for lung cancer
    • FANUCCHI M, GLASPY J, CRAWFORD J et al.: Effects of polyethylene glycol-conjugated recombinant human megakaryocyte growth and development factor on platelet counts after chemotherapy for lung cancer. N. Engl. J. Med. (1997) 336(6):404-409.
    • (1997) N. Engl. J. Med. , vol.336 , Issue.6 , pp. 404-409
    • Fanucchi, M.1    Glaspy, J.2    Crawford, J.3
  • 64
    • 0034050651 scopus 로고    scopus 로고
    • Recombinant human chrombopoietin attenuates carboplatin-induced severe thrombocytopenia and the need for platelet transfusions in patients with gynecologic cancer
    • VADHAN-RAJ S, VERSCHRAEGEN CF, BUESO-RAMOS C et al.: Recombinant human chrombopoietin attenuates carboplatin-induced severe thrombocytopenia and the need for platelet transfusions in patients with gynecologic cancer. Ann. Intern. Med. (2000) 132(5):364-368.
    • (2000) Ann. Intern. Med. , vol.132 , Issue.5 , pp. 364-368
    • Vadhan-Raj, S.1    Verschraegen, C.F.2    Bueso-Ramos, C.3
  • 65
    • 0037100423 scopus 로고    scopus 로고
    • Effects of pegylated recombinant human megakaryocyte growth and development factor in patients with idiopathic thrombocytopenic purpura
    • NOMURA S, DAN K, HOTTA T, FUJIMURA K, IKEDA Y: Effects of pegylated recombinant human megakaryocyte growth and development factor in patients with idiopathic thrombocytopenic purpura. Blood (2002) 100(2):728-730.
    • (2002) Blood , vol.100 , Issue.2 , pp. 728-730
    • Nomura, S.1    Dan, K.2    Hotta, T.3    Fujimura, K.4    Ikeda, Y.5
  • 66
    • 0034781155 scopus 로고    scopus 로고
    • Cyclic immune thrombocytopenia responsive to thrombopoietic growth factor therapy
    • RICE L, NICHOL JL, MCMILLAN R, ROSKOS LK, BACILE M: Cyclic immune thrombocytopenia responsive to thrombopoietic growth factor therapy. Am. J. Hematol. (2001) 68(3):210-214.
    • (2001) Am. J. Hematol. , vol.68 , Issue.3 , pp. 210-214
    • Rice, L.1    Nichol, J.L.2    McMillan, R.3    Roskos, L.K.4    Bacile, M.5
  • 67
    • 0023218341 scopus 로고
    • Mechanisms of thrombocyropenia in chronic autoimmune thrombocytopenic purpura. Evidence of both impaired platelet production and increased platelet clearance
    • BALLEM PJ, SEGAL GM, STRATTON JR et al.: Mechanisms of thrombocyropenia in chronic autoimmune thrombocytopenic purpura. Evidence of both impaired platelet production and increased platelet clearance. J. Clin. Invest. (1987) 80(1):33-40.
    • (1987) J. Clin. Invest. , vol.80 , Issue.1 , pp. 33-40
    • Ballem, P.J.1    Segal, G.M.2    Stratton, J.R.3
  • 68
    • 0043245959 scopus 로고    scopus 로고
    • Immune thrombocytopenic purpura (ITP) plasma and purified ITP monoclonal autoantibodies inhibit megakaryocytopoiesis in film
    • CHANG M, NAKAGAWA PA, WILLIAMS SA et al.: Immune thrombocytopenic purpura (ITP) plasma and purified ITP monoclonal autoantibodies inhibit megakaryocytopoiesis in film. Blood (2003) 102(3):887-895.
    • (2003) Blood , vol.102 , Issue.3 , pp. 887-895
    • Chang, M.1    Nakagawa, P.A.2    Williams, S.A.3
  • 69
    • 0022623857 scopus 로고
    • Platelet turnover and kinetics in immune thrombocytopenic purpura: Results with autologous 111In-labeled platelets and homologous 51Cr-labeled platelets differ
    • HEYNS ADU P, BADENHORST PN, LOTTER MG et al.: Platelet turnover and kinetics in immune thrombocytopenic purpura: results with autologous 111In-labeled platelets and homologous 51Cr-labeled platelets differ. Blood (1986) 67(1):86-92.
    • (1986) Blood , vol.67 , Issue.1 , pp. 86-92
    • Heyns Adu, P.1    Badenhorst, P.N.2    Lotter, M.G.3
  • 70
    • 0029817844 scopus 로고    scopus 로고
    • Regulation of serum thrombopoietin levels by platelets and megakaryocytes patients with aplastic anaemia and idiopathic thrombocytopenic purpura
    • ICHIKAWA N, ISHIDA F, SHIMODAIRA S et al.: Regulation of serum thrombopoietin levels by platelets and megakaryocytes patients with aplastic anaemia and idiopathic thrombocytopenic purpura. Thromb. Haemost. (1996) 76(2):156-160.
    • (1996) Thromb. Haemost. , vol.76 , Issue.2 , pp. 156-160
    • Ichikawa, N.1    Ishida, F.2    Shimodaira, S.3
  • 71
    • 0033485568 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled study with pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) as an adjunct to chemotherapy for adults with de novo acute myeloid leukemia
    • ARCHIMBAUD E, OTTMANN OG, YIN JA et al.: A randomized, double-blind, placebo-controlled study with pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) as an adjunct to chemotherapy for adults with de novo acute myeloid leukemia. Blood (1999) 94(11):3694-3701.
    • (1999) Blood , vol.94 , Issue.11 , pp. 3694-3701
    • Archimbaud, E.1    Ottmann, O.G.2    Yin, J.A.3
  • 72
    • 0033631018 scopus 로고    scopus 로고
    • A Phase I trial of recombinant human thrombopoietin in patients with delayed platelet recovery after hematopoietic stem cell transplantation
    • NASH RA, KURZROCK R, DIPERSIO J et al.: A Phase I trial of recombinant human thrombopoietin in patients with delayed platelet recovery after hematopoietic stem cell transplantation. Biol. Blood Marrow Transplant. (2000) 6(1):25-34.
    • (2000) Biol. Blood Marrow Transplant. , vol.6 , Issue.1 , pp. 25-34
    • Nash, R.A.1    Kurzrock, R.2    Dipersio, J.3
  • 73
    • 0034655649 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled trial of pegylated recombinant human megakaryocyte growth and development factor as an adjunct to induction and consolidation therapy for patients with acute myeloid leukemia
    • SCHIFFER CA, MILLER K, LARSON RA et al.: A double-blind, placebo-controlled trial of pegylated recombinant human megakaryocyte growth and development factor as an adjunct to induction and consolidation therapy for patients with acute myeloid leukemia. Blood (2000) 95(8):2530-2535.
    • (2000) Blood , vol.95 , Issue.8 , pp. 2530-2535
    • Schiffer, C.A.1    Miller, K.2    Larson, R.A.3
  • 74
    • 0035108247 scopus 로고    scopus 로고
    • Cytokine receptor dimerization and activation: Prospects for small molecule agonists
    • BOGER DL, GOLDBERG J: Cytokine receptor dimerization and activation: prospects for small molecule agonists. Bioorg. Med. Chem. (2001) 9(3):557-562.
    • (2001) Bioorg. Med. Chem. , vol.9 , Issue.3 , pp. 557-562
    • Boger, D.L.1    Goldberg, J.2
  • 75
    • 0346881171 scopus 로고    scopus 로고
    • AMG531 stimulates megakaryopoiesis in vitro by binding to Mpl
    • BROUDY VC, LIN NL: AMG531 stimulates megakaryopoiesis in vitro by binding to Mpl. Cytokine (2004) 25(2):52-60.
    • (2004) Cytokine , vol.25 , Issue.2 , pp. 52-60
    • Broudy, V.C.1    Lin, N.L.2
  • 76
    • 33749015400 scopus 로고    scopus 로고
    • Biological activity and selectivity for TPO receptor of the orally bioavailable, small molecule TPO receptor agonist, SB-497115
    • ERICKSON-MILLER CL, DELORME E, GIAMPA L et al.: Biological activity and selectivity for TPO receptor of the orally bioavailable, small molecule TPO receptor agonist, SB-497115. Blood (2005) 106:796a.
    • (2005) Blood , vol.106
    • Erickson-Miller, C.L.1    Delorme, E.2    Giampa, L.3
  • 77
    • 33646481176 scopus 로고    scopus 로고
    • Long-term dosing of AMG 531 is effective and well tolerated in thrombocytopenic patiens with immune thrombocytopenic purpura
    • BUSSEL JB, KUTER DJ, GEORGE JN et al.: Long-term dosing of AMG 531 is effective and well tolerated in thrombocytopenic patiens with immune thrombocytopenic purpura. Blood (2005) 106(11):220.
    • (2005) Blood , vol.106 , Issue.11 , pp. 220
    • Bussel, J.B.1    Kuter, D.J.2    George, J.N.3
  • 78
    • 22244465435 scopus 로고    scopus 로고
    • An open-label, unit dose-finding study evaluationg the safety and platelet response of a novel throbopoietic protein (AMG531) in thrombocytopenic adul patients (Pts) with immune thrombocytopenic purpura (ITP)
    • NEWLAND A, CAULIER MT, SCHIPPERUS MR et al.: An open-label, unit dose-finding study evaluationg the safety and platelet response of a novel throbopoietic protein (AMG531) in thrombocytopenic adul patients (Pts) with immune thrombocytopenic purpura (ITP). Blood (2004) 104(11):2058.
    • (2004) Blood , vol.104 , Issue.11 , pp. 2058
    • Newland, A.1    Caulier, M.T.2    Schipperus, M.R.3
  • 79
    • 32944479985 scopus 로고    scopus 로고
    • Umbilical cord blood transplantation and banking
    • BRUNSTEIN CG, WAGNER JE: Umbilical cord blood transplantation and banking. Annu. Rev. Med. (2006) 57:403-417.
    • (2006) Annu. Rev. Med. , vol.57 , pp. 403-417
    • Brunstein, C.G.1    Wagner, J.E.2
  • 80
    • 0033788193 scopus 로고    scopus 로고
    • Umbilical cord blood transplants
    • GLUCKMAN E, LOCATELLI F: Umbilical cord blood transplants. Curr. Opin. Hematol. (2000) 7(6):353-357.
    • (2000) Curr. Opin. Hematol. , vol.7 , Issue.6 , pp. 353-357
    • Gluckman, E.1    Locatelli, F.2
  • 81
    • 0032569779 scopus 로고    scopus 로고
    • Outcomes among 562 recipients of placental-blood transplants from unrelated donors
    • RUBINSTEIN P, CARRIER C, SCARADAVOU A et al.: Outcomes among 562 recipients of placental-blood transplants from unrelated donors. N. Engl. J. Med. (1998) 339(22):1565-1577.
    • (1998) N. Engl. J. Med. , vol.339 , Issue.22 , pp. 1565-1577
    • Rubinstein, P.1    Carrier, C.2    Scaradavou, A.3
  • 82
    • 0031000903 scopus 로고    scopus 로고
    • Extensive amplification and self-renewal of human primitive hematopoietic stem cells from cord blood
    • PIACIBELLO W, SANAVIO F, GARETTO L et al.: Extensive amplification and self-renewal of human primitive hematopoietic stem cells from cord blood. Blood (1997) 89(8):2644-2653.
    • (1997) Blood , vol.89 , Issue.8 , pp. 2644-2653
    • Piacibello, W.1    Sanavio, F.2    Garetto, L.3
  • 83
    • 0031898017 scopus 로고    scopus 로고
    • Differential growth factor requirement of primitive cord blood hematopoietic stem cell for self-renewal and amplification versus proliferation and differentiation
    • PIACIBELLO W, SANAVIO F, GARETTO L et al.: Differential growth factor requirement of primitive cord blood hematopoietic stem cell for self-renewal and amplification versus proliferation and differentiation. Leukemia (1998) 12(5):718-727.
    • (1998) Leukemia , vol.12 , Issue.5 , pp. 718-727
    • Piacibello, W.1    Sanavio, F.2    Garetto, L.3
  • 84
    • 0033152360 scopus 로고    scopus 로고
    • Engraftment in nonobese diabetic severe combined immunodeficient mice of human CD34(+) cord blood cells after ex vivo expansion: Evidence for the amplification and self-renewal of repopulating stem cells
    • PIACIBELLO W, SANAVIO F, SEVERINO A et al.: Engraftment in nonobese diabetic severe combined immunodeficient mice of human CD34(+) cord blood cells after ex vivo expansion: evidence for the amplification and self-renewal of repopulating stem cells. Blood (1999) 93(11):3736-3749.
    • (1999) Blood , vol.93 , Issue.11 , pp. 3736-3749
    • Piacibello, W.1    Sanavio, F.2    Severino, A.3
  • 85
    • 1442311702 scopus 로고    scopus 로고
    • Fast but durable megakaryocyte repopulation and platelet production in NOD/SCID mice transplanted with ex-vivo expanded human cord blood CD34+ cells
    • BRUNO S, GUNETTI M, GAMMAITONI L et al.: Fast but durable megakaryocyte repopulation and platelet production in NOD/SCID mice transplanted with ex-vivo expanded human cord blood CD34+ cells. Stem Cells (2004) 22(2):135-143.
    • (2004) Stem Cells , vol.22 , Issue.2 , pp. 135-143
    • Bruno, S.1    Gunetti, M.2    Gammaitoni, L.3
  • 86
    • 17144452780 scopus 로고    scopus 로고
    • Megakaryocytic progenitors can be generated ex vivo and safely administered to autologous peripheral blood progenitor cell transplant recipients
    • BERTOLINI F, BATTAGLIA M, PEDRAZZOLI P et al.: Megakaryocytic progenitors can be generated ex vivo and safely administered to autologous peripheral blood progenitor cell transplant recipients. Blood (1997) 89(8):2679-2688.
    • (1997) Blood , vol.89 , Issue.8 , pp. 2679-2688
    • Bertolini, F.1    Battaglia, M.2    Pedrazzoli, P.3
  • 87
    • 0031975145 scopus 로고    scopus 로고
    • In vitro and in vivo evidence that ex vivo cytokine priming of donor marrow cells may ameliorate posttransplant thrombocytopenia
    • RATAJCZAK MZ, RATAJCZAK J, MACHALINSKI B, MICK R, GEWIRTZ AM: In vitro and in vivo evidence that ex vivo cytokine priming of donor marrow cells may ameliorate posttransplant thrombocytopenia. Blood (1998) 91(1):353-359.
    • (1998) Blood , vol.91 , Issue.1 , pp. 353-359
    • Ratajczak, M.Z.1    Ratajczak, J.2    Machalinski, B.3    Mick, R.4    Gewirtz, A.M.5
  • 88
    • 0036330339 scopus 로고    scopus 로고
    • Thrombopoietin expands hematopoietic stem cells after transplantation
    • FOX N, PRIESTLEY G, PAPAYANNOPOULOU T, KAUSHANSKY K: Thrombopoietin expands hematopoietic stem cells after transplantation. J. Clin. Invest. (2002) 110(3):389-394.
    • (2002) J. Clin. Invest. , vol.110 , Issue.3 , pp. 389-394
    • Fox, N.1    Priestley, G.2    Papayannopoulou, T.3    Kaushansky, K.4


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