Neurodegeneration and aldehyde load: From concept to therapeutics

Journal of Psychiatry and Neuroscience

Volumn 31, Issue 5, 2006, Pages 296-297

  Wood, Paul L ^a  

^a Northwestern University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE; AMINOALDEHYDE; ARGINASE; ORNITHINE DECARBOXYLASE; POLYAMINE OXIDASE; PUTRESCINE;

ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; CELL DEATH; CEREBROSPINAL FLUID; CHOLINERGIC NERVE; CLINICAL PRACTICE; DOPAMINERGIC NERVE CELL; EDITORIAL; MEDICAL RESEARCH; MOTONEURON; MULTIPLE SCLEROSIS; NERVE DEGENERATION; NEUROPATHY; NONHUMAN; OLIGODENDROGLIA; PARKINSON DISEASE; REPERFUSION INJURY;

ALDEHYDES; ANIMALS; BRAIN; CELL DEATH; HUMANS; NEURODEGENERATIVE DISEASES; NEUROGLIA; NEURONS; RISK FACTORS;

EID: 33749319812     PISSN: 11804882     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Editorial

References (4)

1. Zarkovic K. 4-hydroxynonenal and neurodegenerative diseases. Mol Aspects Med 2003;24:293-303.
2. Ivanova S, Batliwalla F, Mocco J, et al. Neuroprotection in cerebral ischemia by neutralization of 3-aminopropanal. Proc Natl Acad Sci U S A 2002;99:5579-84.
3. Wood PL, Khan MA, Kulow SR, et al. Neurotoxicity of reactive aldehydes: the concept of "aldehyde load" as demonstrated by neuroprotection with hydroxylamines. Brain Res 2006;1095:190-5.
4. Williams TI, Lynn BC, Markesbery WR, et al. Increased levels of 4-hydroxynonenal and acrolein, neurotoxic markers of lipid peroxidation, in the brain in mild cognitive impairment and early Alzheimer's disease. Neurobiol Aging 2006;27:1094-9.