Epstein-Barr virus associated Hodgkin lymphoma in a 9-year-old girl receiving long-term methotrexate therapy for juvenile idiopathic arthritis

Journal of Pediatric Hematology/Oncology

Volumn 28, Issue 9, 2006, Pages 622-624

  Takeyama, Junji ^a   Sato, Atsushi ^a   Nakano, Kyoko ^a   Abukawa, Daiki ^a   Ichinohazama, Ryo ^b   Imaizumi, Masue ^a  

^a MIYAGI CHILDREN S HOSPITAL   (Japan)

^b TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Epstein Barr virus; Hodgkin lymphoma; Juvenile idiopathic arthritis; Methotrexate

Indexed keywords

ACETYLSALICYLIC ACID; DOXORUBICIN; METHOTREXATE; NAPROXEN; PREDNISONE; PROCARBAZINE; VINCRISTINE;

ANAMNESIS; ARTICLE; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER REGRESSION; CASE REPORT; CLINICAL FEATURE; COMPUTER ASSISTED TOMOGRAPHY; EPSTEIN BARR VIRUS; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; JUVENILE RHEUMATOID ARTHRITIS; LABORATORY TEST; LOW DRUG DOSE; LYMPH NODE BIOPSY; NONHODGKIN LYMPHOMA; PHYSICAL EXAMINATION; PRIORITY JOURNAL; SCHOOL CHILD;

ARTHRITIS, JUVENILE RHEUMATOID; CHILD; DRUG THERAPY, COMBINATION; EPSTEIN-BARR VIRUS INFECTIONS; FEMALE; HERPESVIRUS 4, HUMAN; HODGKIN DISEASE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; METHOTREXATE; NAPROXEN; PREDNISONE; TIME FACTORS; TUMOR VIRUS INFECTIONS;

EID: 33749316405     PISSN: 10774114     EISSN: 15363678     Source Type: Journal    
DOI: 10.1097/01.mph.0000212960.66221.e7     Document Type: Article

References (14)

1. Kamel OW, van de Rijn M, Hanasono MM, et al. Immunosuppression-associated lymphoproliferative disorders in rheumatic patients. Leuk Lymphoma. 1995;16:363-368.
2. Callan MFC. Epstein-Barr virus, arthritis, and the development of lymphoma in arthritis patients. Curr Opin Rheumatol. 2004;16:399-405.
3. Balandraud N, Meynard JB, Auger I, et al. Epstein-Barr virus load in the peripheral blood of patients with rheumatoid arthritis. Arthritis Rheum. 2003;48:1223-1228.
4. Chetty R, Biddolph S, Gatter K. An immunohistochemical analysis of Reed-Sternberg-like cells in posttransplantation lymphoproliferative disorders: the possible pathogenetic relationship to Reed-Sternberg cells in Hodgkin's disease and Reed-Sternberg-like cells in non-Hodgkin's lymphomas and reactive conditions. Hum Pathol. 1997;28:493-498.
5. Dharnidharka VR, Douglas VK, Hunger SP, et al. Hodgkin's lymphoma after post-transplant lymphoproliferative disease in a renal transplant recipient. Pediatr Transplant. 2004;8:87-90.
6. Ranganathan S, Jaffe R. Is there a difference between Hodgkin's disease and a Hodgkin's-like post-transplant lymphoproliferative disorder, and why should that be of any interest? Pediatr Transplant. 2004;8:6-8.
7. Dharnidharka VR, Douglas-Nikitin V. Hodgkin's-like PTLD versus true Hodgkin's disease. Pediatr Transplant. 2004;8:581-582.
8. Moder KG, Tefferi A, Cohen MD, et al. Hematologic malignancies and the use of methotrexate in rheumatoid arthritis: a retrospective study. Am J Med. 1995;99:276-281.
9. Salloum E, Cooper DL, Howe G, et al. Spontaneous regression of lymphoproliferative disorders in patients treated with methotrexate for rheumatoid arthritis and other rheumatic diseases. J Clin Oncol. 1996;14:1943-1949.
10. Kamel OW, Weiss LM, van de Rijn M, et al. Hodgkin's disease and lymphoproliferations resembling Hodgkin's disease in patients receiving long-term low-dose methotrexate therapy. Am J Surg Pathol. 1996;20:1279-1287.
11. Londino AV Jr, Blatt J, Knisely AS. Hodgkin's disease in a patient with juvenile rheumatoid arthritis taking weekly low dose methotrexate. J Rheumatol 1998;25:1245-1246.
12. Padeh S, Sharon N, Schiby G, et al. Hodgkin's lymphoma in systemic onset juvenile rheumatoid arthritis after treatment with low dose methotrexate. J Rheumatol. 1997;24:2035-2037.
13. Krugmann J, Sailer-Hock M, Muller T, et al. Epstein-Barr virus-associated Hodgkin's lymphoma and legionella pneumophila infection complicating treatment of juvenile rheumatoid arthritis with methotrexate and cyclosporine A. Human Pathol. 2000;31:253-255.
14. Munro R, Porter DR, Sturrock RD. Lymphadenopathy in a patient with systemic onset juvenile chronic arthritis. Ann Rheum Dis. 1998;57:513-517.