A novel class of potent nonglycosidic and nonpeptidic pan-selectin inhibitors

Journal of Medicinal Chemistry

Volumn 49, Issue 20, 2006, Pages 5988-5999

  Ulbrich, Holger K ^a   Luxenburger, Andreas ^a   Prech, Philip ^a   Eriksson, Einar E ^b   Soehnlein, Oliver ^b   Rotzius, Pierre ^b   Lindbom, Lennart ^b   Dannhardt, Gerd ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

4 [N [6 [3,5 BIS(DECYLOXY)PHENOXY]HEXYL] N (4 CARBOXYPHENYL)AMINO]BENZOIC ACID; 6 (3,5 DIDECYLOXYPHENOXY)HEXANOIC ACID N,N BIS(4 CARBOXYPHENYL)AMIDE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; L SELECTIN; OLIGOSACCHARIDE; PADGEM PROTEIN; PEPTONE; SELECTIN ANTAGONIST; SIALYL LEWIS X ANTIGEN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG DETERMINATION; DRUG POTENCY; DRUG SYNTHESIS; ENDOTHELIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; IN VITRO STUDY; INFLAMMATION; LEUKOCYTE ADHERENCE; LEUKOCYTE ROLLING; LIGAND BINDING; MALE; MOLECULAR DYNAMICS; MOLECULAR MODEL; MOUSE; NONHUMAN; PERITONITIS; PREDICTION;

4-AMINOBENZOIC ACID; ACUTE DISEASE; ALGORITHMS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BINDING SITES; CASEINS; CELL ADHESION; E-SELECTIN; ENDOTHELIAL CELLS; ENZYME-LINKED IMMUNOSORBENT ASSAY; LEUKOCYTES; LIGANDS; MALE; MICE; MICE, INBRED C57BL; MODELS, MOLECULAR; PEPTIDE FRAGMENTS; PERITONITIS; PROTEIN BINDING; SELECTINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33749260311     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm060468y     Document Type: Article

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