Exploration of the diketoacid integrase inhibitor chemotype leading to the discovery of the anilide-ketoacids chemotype

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 22, 2006, Pages 5818-5821

  Walker, Michael A ^a   Johnson, Timothy ^a   Ma, Zhuping ^a   Zhang, Yunhui ^a   Banville, Jacques ^b   Remillard, Roger ^b   Plamondon, Serge ^b   Pendri, Annapurna ^a   Wong, Henry ^a   Smith, Daniel ^a   Torri, Albert ^a   Samanta, Himadri ^a   Lin, Zeyu ^a   Deminie, Carol ^a   Terry, Brian ^a   Krystal, Mark ^a   Meanwell, Nicholas ^a  

^a BRISTOL MYERS SQUIBB   (United States)

^b Department of Medicinal Chemistry   (Canada)

Author keywords

AIDS; Antiviral; Diketoacid; Human immunodeficiency virus; Integrase; Pyrrolindione

Indexed keywords

AMIDE; INDAPAMIDE; INTEGRASE INHIBITOR; NITROGEN;

ARTICLE; DRUG ACTIVITY; IN VITRO STUDY;

AMIDES; ANILIDES; BINDING SITES; CATIONS; DRUG DESIGN; HIV INTEGRASE INHIBITORS; HIV-1; HUMANS; KETO ACIDS; MAGNESIUM; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

HUMAN IMMUNODEFICIENCY VIRUS;

EID: 33749253137     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.08.075     Document Type: Article

References (17)

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