Assignments of 1H and 13C NMR spectral data for ondansetron and its two novel metabolites, 1-hydroxy-ondansetron diastereoisomers

Magnetic Resonance in Chemistry

Volumn 44, Issue 10, 2006, Pages 972-975

  Duan, Mingyu ^a   Huang, Haihua ^a   Li, Xinnan ^a   Chen, Xiaoyan ^b   Zhong, Dafang ^a,b  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

1 hydroxy ondansetron; 2D NMR; 13C NMR; 1H NMR; Metabolite; Ondansetron

Indexed keywords

BIOMOLECULES; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; QUANTUM THEORY;

1-HYDROXY-ONDANSETRA; 13C NMR; 1H NMR; 2-D NMR; DIASTEREOISOMERS; HETERO-NUCLEAR MULTIPLE BOND CORRELATIONS; HETERONUCLEAR SINGLE-QUANTUM COHERENCES; NMR CHEMICAL SHIFTS; ONDANSETRA; SPECTRAL DATA;

METABOLITES;

1 HYDROXYONDANSETRON; 1-HYDROXYONDANSETRON; CARBON; DRUG DERIVATIVE; HYDROGEN; ONDANSETRON;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; ISOLATION AND PURIFICATION; METABOLISM; MUCOR; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STEREOISOMERISM;

CARBON ISOTOPES; HYDROGEN; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; MUCOR; ONDANSETRON; STEREOISOMERISM;

EID: 33749252390     PISSN: 07491581     EISSN: 1097458X     Source Type: Journal    
DOI: 10.1002/mrc.1876     Document Type: Article

References (7)

1. Blackwell CP, Harding SM. Eur. J. Cancer. Clin. Oncol. 1989; 25(Suppl. 1): S21.
2. Colthup PV, Felgate CC, Palmer JL, Scully NL. J. Pharm. Sci. 1991; 80: 868.
3. Saynor DA, Dixon CM. Eur. J. Cancer. Clin. Oncol. 1989; 25(Suppl. 1): S75.
4. Glaxo Group LTD. 1987; European Patent, 219193.
5. Kim MY, Lim GJ, Lim JI, Kim SK, Kim IY, Yang JS. Heterocycles 1997; 45: 2041.
6. Campos FR, Barison A, Daolio C, Ferreira AG, Rodrigues-Fo E. Magn. Reson. Chem. 2005; 43: 962.
7. Neuhaus D, Williamson MP. The Nuclear Overhauser Effect in Structural and Conformational Analysis (2nd edn). John Wiley and Sons: 2000; 456.