Nutritional supplement chromium picolinate generates chromosomal aberrations and impedes progeny development in Drosophila melanogaster

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 610, Issue 1-2, 2006, Pages 101-113

  Stallings, Dontarie M ^a   Hepburn, Dion D D ^a   Hannah, Meredith ^a   Vincent, John B ^a   O'Donnell, Janis ^a  

^a UNIVERSITY OF ALABAMA   (United States)

Author keywords

Chromium nicotinate; Chromium picolinate; Chromium toxicity; Cr3; Drosophila

Indexed keywords

CHROMIUM PICOLINATE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CHROMOSOME ABERRATION; CHROMOSOME ARM; CHROMOSOME DAMAGE; CONTROLLED STUDY; DEVELOPMENTAL DISORDER; DIET SUPPLEMENTATION; DROSOPHILA MELANOGASTER; FEMALE; FOOD INTAKE; GENETIC DAMAGE; GENOTOXICITY; HATCHING; INSECT CELL CULTURE; LARVAL STAGE; LONGEVITY; MALE; MUTAGENESIS; MUTAGENIC ACTIVITY; NONHUMAN; NUTRITIONAL SUPPORT; PRIORITY JOURNAL; SALIVARY GLAND;

ANIMALS; CHROMIUM COMPOUNDS; CHROMOSOME ABERRATIONS; DROSOPHILA MELANOGASTER; FEMALE; LONGEVITY; MALE; OVUM; PICOLINIC ACIDS;

ANIMALIA; DROSOPHILA MELANOGASTER;

EID: 33749246750     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2006.06.019     Document Type: Article

References (46)

1. Anderson R.A., Bryden N.A., Polansky M.M., and Gautschi K. Dietary chromium effects on tissue chromium concentrations and chromium absorption in rats. J. Trace Elements Exp. Med. 9 (1996) 11-25
2. Vincent J.B. The potential value and toxicity of chromium picolinate as a nutritional supplement, weight loss agent, and muscle development agent. Sports Med. 33 (2003) 213-230
3. Anderson R.A., Bryden N.A., and Polansky M.M. Lack of toxicity of chromium chloride and chromium picolinate in rats. J. Am. Coll. Nutr. 16 (1997) 273-279
4. Davidson J.R.T., Abraham K., Connor K.M., and McLeod M.N. Effectiveness of chromium in atypical depression: a placebo-controlled trial. Biol. Psychiatr. 53 (2003) 261-264
5. Cerulli J., Grabbe D.W., Gauthier I., Malone M., and McGoldrick M.D. Chromium picolinate toxicity. Ann. Pharmacother. 32 (1998) 428-431
6. Wasser W.G., and D'Agati V.D. Chronic renal failure after ingestion of over-the-counter chromium picolinate. Ann. Intern. Med. 126 (1997) 410
7. Huszonek J. Over-the-counter chromium picolinate. Am. J. Pyschiatr. 150 (1993) 1560-1561
8. Vincent J.B. The bioinorganic chemistry of chromium(III). Polyhedron 20 (2003) 1-26
9. Althius M.D., Jordan N.E., Ludington E.A., and Wittes J.T. Glucose and insulin responses to dietary chromium supplements. Am. J. Clin. Nutr. 76 (2002) 148-155
10. Pittler M.H., Stevinson C., and Ernst E. Chromium picolinate for reducing body weight: meta-analysis of randomized trials. Int. J. Obesity 27 (2003) 522-529
11. Yeh G.Y., Kaptchuk T.J., Eisenberg D.M., and Phillips R.S. Systematic review of herbs and dietary supplements for glycemic control in diabetes. Diabetes Care 26 (2003) 1277-1294
12. Stearns D.M., Wise J.P., Patierno Sr. S.R., and Wetterhahn K.E. Chromium(III) picolinate produces chromosome damage in Chinese hamster ovary cells. FASEB J. 9 (1995) 1643-1648
13. Manygoats K.R., Yazzie M., and Stearns D.M. Ultrastructural damage in chromium picolinate-treated cells: a TEM study. J. Biol. Inorg. Chem. 7 (2002) 791-798
14. Stearns D.M., Silviera S.M., Wolf K.K., and Wolf A.M. Chromium(III) tris(picolinate) is mutagenic at the hypoxanthine(guanine) phosphoribosyltransferase locus in Chinese hamster ovary cells. Mutat. Res. 513 (2002) 135-142
15. Bagchi D., Bagchi M., Balmoori J., Ye X., and Stohs S.J. Comparative induction of oxidative stress in cultured J774A.1 macrophage cells by chromium picolinate and chromium nicotinate. Res. Commun. Mol. Pathol. Pharmacol. 97 (1997) 335-346
16. Bagchi D., Stohs S.J., Downs B.W., Bagchi M., and Preuss H.G. Cytotoxicity and oxidative mechanisms of different forms of chromium. Toxicology 180 (2002) 5-22
17. Whittaker P., San R.H.C., Clarke J.J., Seifried H.E., and Dunkel V.C. Mutagenicity of chromium picolinate and its components in Salmonella typhimurium and L5178Y mouse lymphoma cells. Food Chem. Toxicol. 43 (2005) 1619-1625
18. Hepburn D.D.D., Burney J.M., Woski S.A., and Vincent J.B. The nutritional supplement chromium picolinate generates oxidative DNA damage and peroxidized lipids in vivo. Polyhedron 22 (2003) 455-463
19. Mahboob L., McNeil L., Toliver T., and Ogden L. Effects of chromium picolinate on antioxidant enzyme levels in rats. Toxicol. Sci. 66 1-S (2002) 32
20. Hepburn D.D.D., Xiao J., Bindom S., Vincent J.B., and O'Donnell J. Nutritional supplement chromium picolinate causes sterility and lethal mutations in Drosophila melanogaster. Proc. Natl. Acad. Sci. U.S.A. 100 (2003) 3766-3771
21. Speetjens J.K., Collins R.A., Vincent J.B., and Woski S.A. The nutritional supplement chromium(III) tris(picolinate) cleaves DNA. Chem. Res. Toxicol. 12 (1999) 483-487
22. Sun Y., Ramirez J., Woski S.A., and Vincent J.B. The binding of chromium to low-molecular-weight chromium-binding substance (LMWCr) and the transfer of chromium from transferrin and chromium picolinate to LMWCr. J. Biol. Inorg. Chem. 5 (2000) 129-136
23. Blankert S.A., Coryell V.H., Picard B.T., Wolf K.K., Lomas R.E., and Stearns D.M. Characterization of nonmutagenic Cr(III)-DNA interactions. Chem. Res. Toxicol. 16 (2003) 847-854
24. Press R., Geller J., and Evans G.W. The effect of chromium picolinate on serum cholesterol and apoolipoprotein fractions in human subjects. West. J. Med. 152 (1990) 41-45
25. Kharmawphlang W., Choudhury S., Deb A.K., and Goswami S. Convenient approach to the direct syntheses of chromium complexes from chromium(III) chloride. Inorg. Chem. 34 (1995) 3826-3828
26. Cooper J.A., Anderson B.F., Buckley P.D., and Blackwell L.F. Structure and biological activity of nitrogen and oxygen coordinated nicotinic acid complexes of chromium. Inorg. Chim. Acta 91 (1994) 1-9
27. Earnshaw A., Figgis B.N., and Lewis J. Chemistry of polynuclear compounds. Part IV. Magnetic properties of trimeric chromium and iron carboxylates. Chem. Soc. A (1966) 1656-1663
28. O'Donnell J., Boswell R., Reynolds T., and Mackay W. A cytogenetic analysis of the Punch-tudor region of chromosome 2R in Drosophila melanogaster. Genetics 121 (1980) 273-280
29. Lindsley D.L., and Zimm G.G. The Genome of Drosophila melanogaster vol. I (1992), Academic Press, San Diego, CA
30. Sugden K.D., Greer R.D., and Rogers S.G. Oxygen radical-mediated DNA damage by redox-active Cr(III) complexes. Biochemistry 31 (1992) 11626-11631
31. Kingry K., Royer A.C., and Vincent J.B. Nuclear magnetic resonance studies of chromium(III) pyridinecarboxylate complexes. J. Inorg. Biochem. 72 (1998) 79-88
32. Evans G.W., and Puochnik D.J. Composition and biological activity of chromium-pyridine carboxylate complexes. J. Inorg. Biochem. 49 (1993) 177-187
33. + decreases plasma cholesterol and triglycerides in rats: towards chromium-containing therapeutics. J. Biol. Inorg. Chem. 4 (1999) 838-845
34. + decreases plasma insulin, cholesterol and triglycerides in healthy and type II diabetic rats but not type I diabetic rats. J. Biol. Inorg. Chem. 7 (2002) 852-862
35. + increases insulin sensitivity and improves blood variables in healthy and type 2 diabetic rats. J. Biol. Inorg. Chem. 10 (2005) 119-130
36. Striffler J.S., Law J.S., Polansky M.M., Bhathena S.J., and Anderson R.A. Chromium improves insulin response to glucose in rats. Metabolism 44 (1995) 1314-1320
37. Anderson R.A., and Kozlovsky A.S. Chromium intake, absorption and excretion of subjects consuming self-selected diets. Am. J. Clin. Nutr. 41 (1985) 1177-1183
38. Mulyani I., Levina A., and Lay P.A. Biomimetic oxidation of chromium(III): does the antidiabetic activity of chromium(III) involve carcinogenic chromium(VI)?. Angew. Chem. Int. Ed. 43 (2004) 4504-4507
39. Bannister W.H., Bannister J.V., Searle A.J.F., and Thornalley P.J. The reaction of superoxide radicals with metal picolinate complexes. Inorg. Chim. Acta 78 (1983) 139-142
40. Fernandez-Pol J.A. Morphological changes induced by picolinic acid in cultured mammalian cells. Exp. Mol. Pathol. 29 (1978) 348-357
41. 1 by picolinic acid. Biochem. Biophys. Res. Commun. 76 (1976) 413-419
42. 1 arrest induced in NRK cells by picolinic acid. Biochem. Biophys. Res. Commun. 78 (1977) 136-143
43. Kareus S.A., Kelly C., Walton H.S., and Sinclair P.R. Release of Cr(III) from Cr(III) picolinate upon metabolic activation. J. Hazard. Mater. B 84 (2001) 163-174
44. Levinson Z.H., and Bergmann E.D. Vitamin deficiencies in the housefly produced by antivitamins. J. Insect. Physiol. 3 (1959) 293-305
45. Tsiropoulos G.J., and Hagen K.S. Effect of nutritional deficiencies, produced by antimetabolites, on the reproduction of Rhagoletis completa Cresson (Dipt., Tephritidae). J. Appl. Entomol. 103 (1987) 351-354
46. Tsiropoulos G.J. Dietary administration of antivitamins affected the survival and reproduction of Dacus oleae. Zeit. Angew. Entolmol. 100 (1985) 35-39