Postoperative irradiation in breast cancer patients with one to three positive axillary lymph nodes: Is there an impact of axillary extranodal tumor extension on locoregional and distant control?

Strahlentherapie und Onkologie

Volumn 182, Issue 10, 2006, Pages 583-588

  Stranzl, Heidi ^a   Ofner, Petra ^a   Peintinger, Florentia ^b  

^a MEDICAL UNIVERSITY OF GRAZ   (Austria)

^b Division of Gynecology   (Austria)

Author keywords

Breast carcinoma; Extracapsular extension; Positive axillary lymph nodes; Radiotherapy

Indexed keywords

ADULT; AGE DISTRIBUTION; AGED; AXILLARY LYMPH NODE; BREAST CARCINOMA; CANCER PATIENT; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER SURVIVAL; CONFERENCE PAPER; CONFIDENCE INTERVAL; CONTROLLED STUDY; DISEASE FREE SURVIVAL; DISEASE SEVERITY; FEMALE; HISTOLOGY; HUMAN; LYMPH NODE DISSECTION; LYMPH NODE IRRADIATION; LYMPH NODE METASTASIS; LYMPHADENECTOMY; MAJOR CLINICAL STUDY; MEDICAL RECORD REVIEW; MULTIVARIATE ANALYSIS; POSTOPERATIVE CARE; RADIATION FIELD; SURVIVAL RATE; SURVIVAL TIME; TREATMENT OUTCOME;

ADULT; AGED; AGED, 80 AND OVER; AUSTRIA; AXILLA; BREAST NEOPLASMS; FEMALE; HUMANS; LYMPHATIC METASTASIS; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; POSTOPERATIVE CARE; PROGNOSIS; RADIOTHERAPY, ADJUVANT; RETROSPECTIVE STUDIES; RISK ASSESSMENT; RISK FACTORS; SURVIVAL RATE; TREATMENT OUTCOME;

EID: 33749241919     PISSN: 01797158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00066-006-1562-4     Document Type: Conference Paper

References (24)

1. Axelsson CK, Mouridsen HT, Zedeler K. Axillary dissection of level I and II lymph nodes is important in breast cancer classification. The Danish Breast Cancer Cooperative Group (DBCG). Eur J Cancer 1992;28A:1415-8.
2. Bucci JA, Kennedy CW, Burn J, et al. Implications of extranodal spread in node positive breast cancer: a review of survival and local recurrence. Breast 2001;10:213-9.
3. Chua B, Olivotto IA, Weir L, et al. Increased use of adjuvant regional radiotherapy for node-positive breast cancer in British Columbia. Breast J 2004;10:38-44.
4. Donegan WL, Stine SB, Samter TG. Implications of extracapsular nodal metastases for treatment and prognosis of breast cancer. Cancer 1993;72:778-82.
5. Dörr W, Bertmann, Herrmann T. Radiation-induced lung reactions. Strahlenther Onkol 2005;181:567-73.
6. Fowble B, Solin LJ, Schultz DJ, et al. Frequency, sites of relapse and outcome of regional node failures following conservative surgery and radiation for early stage breast cancer. Int J Radiat Oncol Biol Phys 1989;27:703-10.
7. Grabenbauer GG. Internal mammary nodes in invasive breast carcinoma. To treat or not to treat? Strahlenther Onkol 2004;180:690-4.
8. Gruber G, Berclaz G, Altermatt HJ, et al. Can the addition of regional radiotherapy counterbalance important risk factors in breast cancer patients with extracapsular invasion of axillary lymph node metastases? Strahlenther Onkol 2003;179:661-6.
9. Gruber G, Menzi S, Forster A, et al. Sites of failure in breast cancer patients with extracapsular invasion of axillary lymph node metastases. Strahlenther Onkol 2005;181:574-9.
10. Hetelekidis S, Schnitt SJ, Silver B, et al. The significance of extracapsular extension of axillary lymph node metastases in early-stage breast cancer. Int J Radiat Oncol Biol Phys 2000;46:31-4.
11. Kuske RR, Hayden D, Bischoff R, et al. The impact of extracapsular axillary nodal extension (ECE) with and without irradiation on patterns of recurrence and survival from breast cancer. Int J Radiat Oncol Biol Phys 1996;26:277.abstract.
12. Leonard C, Corkill M, Tompkin J, et al. Are axillary recurrence and overall survival affected by axillary extranodal tumor extension in breast cancer? Implications for radiation therapy. J Clin Oncol 1995;13:47-53.
13. Overgaard M, Hansen PS, Overgaard J, et al. Postoperative radiotherapy in high-risk pre-menopausal women with breast cancer who receive adjuvant chemotherapy. N Engl Med 1997;337:949-55.
14. Overgaard M, Jensen MB, Overgaard J, et al. Postoperative radiotherapy in high-risk postmenopausal breast cancer patients given adjuvant tamoxifen: Danish Breast Cancer Cooperative Group DBCG 82c randomized trial. Lancet 1999;353:1641-8.
15. Pierce LJ, Oberman HA, Strawderman MH, et al. Microscopic extracapsular extension in the axilla: is this an indication for axillary radiotherapy? Int J Radiat Oncol Biol Phys 1995;33:253-9.
16. Ragaz J, Jackson SM, Le N, et al. Adjuvant radiotherapy and chemotherapy in node-positive pre-menopausal women with breast cancer. N Engl J Med 1997;337:956-62.
17. Recht A, Edge SB, Solin LJ, et al. Postmastectomy radiotherapy: clinical practice guidelines of the American Society of Clinical Oncology. J Clin Oncol 2001;19:1539-69.
18. Recht A, Gray R, Davidson NE, et al. Local-regional failure ten years following mastectomy and adjuvant chemotherapy with or without tamoxifen without radiation. Experience of the Eastern Cooperative Oncology Group. J Clin Oncol 1999;17:1689-700.
19. Recht A, Pierce SM, Abner A, et al. Regional nodal failure after conservative surgery and radiotherapy for early stage breast carcinoma. J Clin Oncol 1991;9:988-96.
20. Sautter-Bihl ML, Hültenschmidt B, Melcher U, et al. Radiotherapy of internal mammary lymph nodes in breast cancer. Strahlenther Onkol 2002;178:18-24.
21. Sobin LH, Wittekind C. TNM classification of malignant tumours, 6th edn. New York: Wiley-Liss, 2002.
22. Stranzl H, Mayer R, Ofner P, et al. Extracapsular extension in axillary positive lymph nodes in female breast cancer patients. Patterns of failure and indications for postoperative locoregional irradiation. Strahlenther Onkol 2004;180:31-7.
23. Stranzl H, Peintinger F, Ofner P, et al. Regional nodal recurrence in the management of breast cancer patients with 1-3 positive axillary lymph nodes. Outcome of patients following tangential irradiation without a separate nodal field. Strahlenther Onkol 2004;180:623-8.
24. Vicini FA, Horwitz EM, Lacerna MD, et al. The role of regional nodal irradiation in the management of patients with early-stage breast cancer treated with breast-conserving therapy. Int J Radiat Oncol Biol Phys 1997;39:1069-76.