Ayahuasca central nervous system effects: Behavioral study

Arztezeitschrift fur Naturheilverfahren und Regulationsmedizin

Volumn 47, Issue 7, 2006, Pages 476-480

  Lima, Leonardo Mandalho ^b   Ferreira, Miller Santos ^b   Ávila, Ana Augusta ^b   Perazzo, Fábio Ferreira ^b   Schneedorf, José Maurízio ^b   Carvalho, José Carlos Tavares ^a  

^a Unifenas   (Brazil)

^b NONE

Author keywords

Antidepressant; Ayahuasca beverage; Forced swimming; Locomotor activity

Indexed keywords

AMPHETAMINE DERIVATIVE; ANFEPRAMONE; ANTIDEPRESSANT AGENT; BANISTERIOPSIS CAAPI EXTRACT; DIAZEPAM; FLUOXETINE; HARMALOL; HARMAN; HARMOL; HERBACEOUS AGENT; N,N DIMETHYLTRYPTAMINE; PSYCHOTRIA VIRIDIS EXTRACT; SANTO DAIME; TRANYLCYPROMINE; UNCLASSIFIED DRUG; VANOXERINE; VEGETABLE UNION;

ANIMAL EXPERIMENT; ARTICLE; BANISTERIOPSIS; BEHAVIORAL SCIENCE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG EFFECT; FORCED SWIMMING TEST; LETHAL DOSE; MALE; MALPIGHIACEAE; NONHUMAN; OPEN FIELD TEST; PHYTOCHEMISTRY; PSYCHOTRIA; RAT; RUBIACEAE; THIN LAYER CHROMATOGRAPHY;

EID: 33749181744     PISSN: 16148339     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. METZNER, R.: Amazonian vine of visions. In: R. METZNER (ed) Ayahuasca. Hallucinogens, consciousness and the spirit of nature. Thunder's Mouth Press, New York. 1999.
2. MARSHALL, J.: Daimismo, la comunión con la ayahuasca. Integral. 1 (1997) 16-23.
3. LÓPEZ, P.: Ayahuasca, el último alucine. Tiempo. 910 (1999) 26-28.
4. RIBA, J., A. RODRÍGUEZ, F. G. URBANO, A. MORTE, R. ANTONIJOAN, M. MONTERO, J. C. CALLAWAY, M. J. BARBANOJ: Subjective effects and tolerability of the South American psychoactive beverage Ayahuasca in healthy volunteers. Psychopharmacology. 154 (2001) 85-95.
5. RIVIER, L., J. LINDGREN: Ayahusca, the South American hallucinogenic drink: ethnobotanical and chemical investigations. Econ. Bot. 29 (1972) 101-129.
6. CALLAWAY, J. C., L. P. RAYMON, W. L. HEARN, D. J. MCKENNA, C. S. GROB, G. C. BRITO, D. C. MASH: Quantitation of N,N-dimethyltryptamine and harmalol alkaloids in human plasma after oral dosing with Ayahuasca. J. A. Toxicol. 20 (1996) 487-492.
7. LIWSZYC, G. E., E. VUORI, I. RASANEN, J. ISSAKAINEN: Daime - a ritual herbal potion. J. Ethnopharmacology 36 (1992) 91-92.
8. CALLAWAY, J. C., D. J. MCKENNA, C. S. GROB, G. S. BRITO, L. P. RAYMON, R. E. PLAND, E. N. ANDRADE, E. O. ANDRADE, D. C. MASH: Pharmacology of hoasca alkaloids in healthy humans. J. Ethnopharmacology 65 (1999) 243-256.
9. Brazilian Pharmacopoeia, IV edition, Atheneu Editorial, 2000.
10. BARBOSA, W. L. R.: Manual para análise fitoquímica e cromatográfica de extratos vegetais. Revista Científica da UFPA 4 (2004) 1-19.
11. HARBONE, J. B., H. BAXTER: Phytochemical dictionary: a handbook of bioactive compounds from plants. Taylor & Francis, London, 1995.
12. WAGNER, H., S. E. BLADT: Plant Drug Analysis - A Thin Layer Chromatography. Ed. Springer-Verlag, Berlin, 1984.
13. MILLER, L. C., M. L. TAINTER: Proc. Soc. Biol. Med. 57 (1944) 261.
14. PORSOLT, R. D., G. ANTON, N. BLAVET, M. JALFRE: Behavior despair in rats: A new model sensitive to antidepressant treatments. Eur. J. Pharmacol. 47 (1978) 379-391.
15. DETKE, M. J., M. RICKELS, I. LUCKI: Active behaviors in the rat FST differentially produced by serotonergic and noradrenergic antidepressants. Psychopharmacology. 119 (1995) 47-54.
16. ALMAGRO, C. B.: Esquemas y practices de farmacologia. Editorial Espaxs. (1976) 283pp.
17. JONES, B. J., D. J. ROBERTS: The quantitative measurement of motor incoordination in naïve mice using an accelerating Rota-Rod. J. Pharm. Pharmac., 20 (1968) 302-304.
18. BORSINI, F., A. MELI: Is the forced swimming test a suitable model for revealing antidepressant activity? Psychopharmacology 94 (1988) 147-160
19. WILLNER, P.: The validity of animal models of depression. Psychopharmacology. 83 (1984) 1-16.
20. REDOBRE, J. P., C. P. MACSWEENEY, M. BOURIN: The role of 5-HT1A and 5-HT 1B receptors in antidepressant drug actions in the mouse forced swimming test. Eur. J. Pharmacol. 318 (1996) 213-220.
21. HEMBY, S. E., I. LUCKI, G. GATTO, A. SINOH, C. THORNLEY, J. MATASI, N. KONG, J. E. SMITH, H. M. L. DAVIES, S. I. DWORKIN: Potential antidepressant effects of novel tropane compounds, selective for serotonin or dopamine transporters. JPET. 282 (1997) 727-733
22. RÉNÉRIC, J. P., M. BOUVARD, L. STINUS: In the rat forced swimming test, chronic but not subacute administration of dual 5-HT/NA antidepressant treatments may produce greater effects than selective drugs. Behavioral Brain Research. 136 (2002) 521-536.
23. MAR, A., E. SPREEKMEESTER, J. ROCHFORD: Fluoxetine-induced increases in open-field habituation in the olfactory bulbectomized rat depend on test aversiveness but not on anxiety. Pharmacology, Biochemistry and Behavior. 73 (2002) 703-712.
24. PIERCE, P., S. PEROUTKA: Hallucinogenic drug interactions with neurotransmitter receptor binding sites in human cortex. Psychopharmacol. 97 (1989) 118-122.
25. DELIGANIS, A., P. PIERCE, S. PEROUTKA: Differential interactions of dimethyltryptamine (DMT) with 5-HT1A and 5-HT 2 receptors. Biochem. Pharmacol. 41 (1991) 1739-1744.
26. MCKENNA, D. J., G. H. N. TOWERS, F. ABBOTT: Monoamine oxidase inhibitors in South American hallucinogenic plants: tryptamine and beta-carbonile constituents of ayahuasca. J. Ethnopharmacology. 10 (1984) 195-223.
27. BRÆSTRUP, C., SCHEEL-KRÜGER: Methylphenidate-like effects of the new antidepressant drug nomifensine (OHE 984). Eur. J. Pharmacol. 38 (1976) 305.
28. COSTAL, B., D. M. KELLY, R. J. NAYLOR: Nomifensine: a potent dopaminergic agonist of antiparkinson potential. Psychopharmacologia. 41 (1975) 153.
29. SØGAARD, U., J. MICHALOW, B. BUTLER, A. L. LAURSEN, S. H. INGERSEN, B. K. SKRUMSAGER, O. J. RAFAELSEN: A tolerance study of single and multiple dosing of the selective dopamine uptake inhibitor GBR12909 in healthy subjects. International Clinical Psychopharmacology. 5 (1990) 237.
30. MUELLER, K.: Locomotor stereotypy is produced by methylphenidate and anfonelic acid and reduced by haloperidol but not clozapine or thioridazine. Pharmacology, Biochemistry and Behavior. 45 (1993) 71.
31. WESTERINK, B. H. C., G. DAMSMA, J. B. DE VRIES, H. KONING: Dopamine re-uptake inhibitors show consistent effects on the in vivo release of dopamine as measured by intracerebral dialysis in the rat. Eur. J. Pharmacol. 135 (1987) 123.
32. NAKACHI, N., Y. KIUCHI, M. INAGAKI, M. INAZU, Y. YAMAZAKI, K. OGUCHI: Effects of various dopamine uptake inhibitors on striatal extracellular dopamine levels and behaviours in rats. Eur. J. Pharmacol. 281 (1995) 195-203.