Oculomotor instabilities in zebrafish mutant belladonna: A behavioral model for congenital nystagmus caused by axonal misrouting

Journal of Neuroscience

Volumn 26, Issue 39, 2006, Pages 9873-9880

  Huang, Ying Yu ^a   Rinner, Oliver ^a   Hedinger, Patrik ^a   Liu, Shih Chii ^a   Neuhauss, Stephan C F ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Achiasmatic; Axonal misrouting; Behavioral genetics; Congenital nystagmus; Oculomotor instability; Quantitative model; Retinal ganglion cell axons; Reversed optokinetic response; Zebrafish

Indexed keywords

BELLADONNA ALKALOID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EMBRYO; EYE MOVEMENT; NERVE FIBER; NONHUMAN; NYSTAGMUS; OCULOMOTOR NERVE DISEASE; OPTOKINETIC STIMULATION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RETINA GANGLION CELL; ZEBRA FISH;

ANIMALS; AXONS; COMPUTER SIMULATION; CONTRAST SENSITIVITY; CROSSES, GENETIC; DISEASE MODELS, ANIMAL; EYE MOVEMENTS; LARVA; MODELS, NEUROLOGICAL; MORPHOGENESIS; MOTION PERCEPTION; NERVE TISSUE PROTEINS; NYSTAGMUS, OPTOKINETIC; NYSTAGMUS, PATHOLOGIC; OPTIC CHIASM; PHOTIC STIMULATION; RETINAL GANGLION CELLS; ZEBRAFISH; ZEBRAFISH PROTEINS;

EID: 33749176979     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2886-06.2006     Document Type: Article

References (30)

1. Abadi RV, Pascal E (1994) Periodic alternating nystagmus in humans with albinism. Invest Ophthalmol Vis Sci 35:4080-4086.
2. Apkarian P, Bour LJ (2001) See-saw nystagmus and congenital nystagmus identified in the non-decussating retinal-fugal fiber syndrome. Strabismus 9:143-163.
3. Apkarian P, Bour L, Barth PG (1994) A unique achiasmatic anomaly detected in non-albinos with misrouted retinal-fugal projections. Eur J Neurosci 6:501-507.
4. Apkarian P, Bour LJ, Barth PG, Wenniger-Prick L, Verbeeten Jr B (1995) Non-decussating retinal-fugal fibre syndrome. An inborn achiasmatic malformation associated with visuotopic misrouting, visual evoked potential ipsilateral asymmetry and nystagmus. Brain 118:1195-1216.
5. Collewijn H, Grootendorst AF (1978) Adaptation of the rabbit's vestibulo-ocular reflex to modified visual input: importance of stimulus conditions. Arch Ital Biol 116:273-280.
6. Collewijn H, Apkarian P, Spekreijse H (1985) The oculomotor behaviour of human albinos. Brain 108:1-28.
7. Dell'Osso LF, Williams RW (1995) Ocular motor abnormalities in achiasmatic mutant Belgian sheepdogs: unyoked eye movements in a mammal. Vision Res 35:109-116.
8. Dell'Osso LF, Williams RW, Jacobs JB, Erchul DM (1998) The congenital and see-saw nystagmus in the prototypical achiasma of canines: comparison to the human achiasmatic prototype. Vision Res 38:1629-1641.
9. Donaghy M (1980) The contrast sensitivity, spatial resolution and velocity tuning of the cat's optokinetic reflex. J Physiol (Lond) 300:353-365.
10. Easter Jr SS, Schmidt JT (1977) Reversed visuomotor behavior mediated by induced ipsilateral retinal projections in goldfish. J Neurophysiol 40:1245-1254.
11. Feinsod M (2000) The blind beautiful eye. J Neuroophthalmol 20:22-24.
12. Glasauer S, Schneider E, Jahn K, Strupp M, Brandt T (2005) How the eyes move the body. Neurology 65:1291-1293.
13. Haffter P, Granato M, Brand M, Mullins MC, Hammerschmidt M, Kane DA, Odenthal J, van Eeden FJ, Jiang YJ, Heisenberg CP, Kelsh RN, Furutani-Seiki M, Vogelsang E, Beuchle D, Schach U, Fabian C, Nusslein-Volhard C (1996) The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio. Development 123:1-36.
14. Halmagyi GM, Gresty MA, Leech J (1980) Reversed optokinetic nystagmus (OKN): mechanism and clinical significance. Ann Neurol 7:429-435.
15. Harris LR, Smith AT (2000) Interactions between first- and second-order motion revealed by optokinetic nystagmus. Exp Brain Res 130:67-72.
16. Hogan D, Williams RW (1995) Analysis of the retinas and optic nerves of achiasmatic Belgian sheepdogs. J Comp Neurol 352:367-380.
17. Jahn K, Strupp M, Krafczyk S, Schuler O, Glasauer S, Brandt T (2002) Suppression of eye movements improves balance. Brain 125:2005-2011.
18. Jeffery G (1997) The albino retina: an abnormality that provides insight into normal retinal development. Trends Neurosci 20:165-169.
19. Karlstrom RO, Trowe T, Klostermann S, Baier H, Brand M, Crawford AD, Grunewald B, Haffter P, Hoffmann H, Meyer SU, Muller BK, Richter S, van Eeden FJ, Nusslein-Volhard C, Bonhoeffer F (1996) Zebrafish mutations affecting retinotectal axon pathfinding. Development 123:427-438.
20. Korff CM, Apkarian P, Bour LJ, Meuli R, Verrey JD, Roulet Perez E (2003) Isolated absence of optic chiasm revealed by congenital nystagmus, MRI and VEPs. Neuropediatrics 34:219-223.
21. Leguire LE, Zaff BS, Freeman S, Rogers GL, Bremer DL, Wali N (1991) Contrast sensitivity of optokinetic nystagmus. Vision Res 31:89-97.
22. Mullins MC, Hammerschmidt M, Haffter P, Nusslein-Volhard C (1994) Large-scale mutagenesis in the zebrafish: in search of genes controlling development in a vertebrate. Curr Biol 4:189-202.
23. Neuhauss SC, Biehlmaier O, Seeliger MW, Das T, Kohler K, Harris WA, Baier H (1999) Genetic disorders of vision revealed by a behavioral screen of 400 essential loci in zebrafish. J Neurosci 19:8603-8615.
24. Rick JM, Horschke I, Neuhauss SC (2000) Optokinetic behavior is reversed in achiasmatic mutant zebrafish larvae. Curr Biol 10:595-598.
25. Rinner O, Rick JM, Neuhauss SC (2005) Contrast sensitivity, spatial and temporal tuning of the larval zebrafish optokinetic response. Invest Ophthalmol Vis Sci 46:137-142.
26. Seth A, Culverwell J, Walkowicz M, Toro S, Rick JM, Neuhauss SC, Varga ZM, Karlstrom RO (2006) Belladonna/(lhx2) is required for neural patterning and midline axon guidance in the zebrafish forebrain. Development 133:725-735.
27. Shallo-Hoffmann J, Faldon M, Tusa RJ (1999) The incidence and waveform characteristics of periodic alternating nystagmus in congenital nystagmus. Invest Ophthalmol Vis Sci 40:2546-2553.
28. St John R, Fisk JD, Timney B, Goodale MA (1984) Eye movements of human albinos. Am J Optom Physiol Opt 61:377-385.
29. Wilhelm H, Wilhelm B, Schiefer U (1991) Mydriasis caused by plant contact. Fortschr Ophthalmol 88:588-591.
30. Williams RW, Hogan D, Garraghty PE (1994) Target recognition and visual maps in the thalamus of achiasmatic dogs. Nature 367:637-639.