Pharmacokinetics of chlorhexidine gluconate 0.02% in the rabbit cornea

Journal of Ocular Pharmacology and Therapeutics

Volumn 22, Issue 4, 2006, Pages 227-230

  Xuguang, Sun ^a   Yanchuang, Liang ^a   Feng, Zhang ^b   Shiyun, Luo ^a   Xiaotang, Yin ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORHEXIDINE GLUCONATE; EYE DROPS; CHLORHEXIDINE; DRUG DERIVATIVE; TOPICAL ANTIINFECTIVE AGENT;

ANIMAL TISSUE; ANTIPROTOZOAL ACTIVITY; ARTICLE; COMPARTMENT MODEL; CONTROLLED STUDY; CORNEA; DRUG CLEARANCE; DRUG HALF LIFE; DRUG INSTILLATION; DRUG TISSUE LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; RABBIT; TROPHOZOITE MINIMUM AMOEBICIDAL CONCENTRATION; ANIMAL; METABOLISM; TISSUE DISTRIBUTION; TOPICAL DRUG ADMINISTRATION;

ADMINISTRATION, TOPICAL; ANIMALS; ANTI-INFECTIVE AGENTS, LOCAL; CHLORHEXIDINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CORNEA; OPHTHALMIC SOLUTIONS; RABBITS; TISSUE DISTRIBUTION;

EID: 33749123708     PISSN: 10807683     EISSN: None     Source Type: Journal    
DOI: 10.1089/jop.2006.22.227     Document Type: Article

References (7)

1. Seal, D., Hay, J., Kirkness, C., et. al. Successful medical therapy of Acanthamoeba keratitis with topical chlorhexidine and propamidine. Eye 10(Pt 4):413-421, 1996.
2. Kosrirukvongs, P., Wanachiwanawin, D., and Visvesvara, G.S. Treatment of Acanthamoeba keratitis with chlorhexidine. Ophthalmology 106(4):798-802, 1999.
3. Wysenbeek, Y.S., Blank-Porat, D., Harizman, N., et. al. The reculture technique: Individualizing the treatment of Acanthamoeba keratitis. Cornea 19(4):464-467, 2000.
4. Narasimhan, S., Hadhavan, H.N., and Lily, T.K. Development and application of an in vitro susceptibility test for Acanthamoeba species isolated from keratitis to polyhexamethylene biguanide and chlorhexidine. Cornea 21(2):203-205, 2002.
5. Pesonen, T., Holmalahti, J., and Pohjola, J. Determination of chlorhexidine in saliva using high-performance liquid chromatography. J. Chromatog. B. Biomed. Appl. 665(1):222-225, 1995.
6. Xuguang, S., and Xiuying, J. Pathogenic free-living amoebic keratitis in China. Ophthalmol. China 11(1):4-6, 2002.
7. Elder, M.J., Kilvington, S., and Dart, J.K. A clinicopathologic study of in vitro sensitivity testing and Acanthamoeba keratitis. Invest. Ophthalmol. Vis. Sci. 35(3):1059-1064, 1994.