Understanding proarrhythmic potential in therapeutic drug development: alternate strategies for measuring and tracking repolarization

Journal of Electrocardiology

Volumn 39, Issue 4 SUPPL., 2006, Pages

  Lux, Robert L ^a   Gettes, Leonard S ^b   Mason, Jay W ^c  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c UK   (United States)

Author keywords

Cardiac safety; Repolarization; RMS ECG

Indexed keywords

UNCLASSIFIED DRUG;

ARTICLE; ELECTROCARDIOGRAM; ELECTROCARDIOGRAPHY MONITORING; HEART DEPOLARIZATION; HEART ELECTROPHYSIOLOGY; HEART MUSCLE POTENTIAL; HEART PROARRHYTHMIA; HEART RATE VARIABILITY; HEART REPOLARIZATION; HEART VENTRICLE PERFORMANCE; HOLTER MONITORING; MEDICAL ASSESSMENT; NON INVASIVE MEASUREMENT; PRIORITY JOURNAL; QRS COMPLEX; QT INTERVAL; R WAVE; SIGNAL DETECTION; T WAVE; VECTORCARDIOGRAPHY;

ANTI-ARRHYTHMIA AGENTS; ARRHYTHMIA; DIAGNOSIS, COMPUTER-ASSISTED; DRUG DESIGN; ELECTROCARDIOGRAPHY; HUMANS; TREATMENT OUTCOME;

EID: 33749078541     PISSN: 00220736     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jelectrocard.2006.05.020     Document Type: Article

References (4)

1. Fuller M.S., Sandor G., Punske B., et al. Estimates of repolarization dispersion from electrocardiographic measurements. Circulation 102 (2000) 685
2. Fuller M.S., Sandor G., Punske B., et al. Estimates of repolarization and its dispersion from electrocardiographic measurements: direct epicardial assessment in the canine heart. J Electrocardiol 33 (2000) 171
3. Lux R.L., Fuller M.S., MacLeod R.S., et al. Noninvasive indices of repolarization and its dispersion. J Electrocardiol 32 Suppl (1999) 153
4. Lux R.L., Fuller M.S., MacLeod R.S., et al. QT interval dispersion: dispersion of ventricular repolarization or dispersion of QT interval?. J Electrocardiol 30 Suppl (1998) 176