Short-term, but not post-exposure, protection against lethal orthopoxvirus challenge after immunization with modified vaccinia virus Ankara

Journal of General Virology

Volumn 87, Issue 10, 2006, Pages 2917-2921

  Staib, Caroline ^a   Suezer, Yasemin ^b   Kisling, Sigrid ^a   Kalinke, Ulrich ^b   Sutter, Gerd ^b  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b PAUL EHRLICH INSTITUT   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANKARA; UNCLASSIFIED DRUG; VACCINIA VACCINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; DEATH; DISEASE SEVERITY; DRUG EXPOSURE; IMMUNIZATION; INNATE IMMUNITY; INOCULATION; LETHALITY; LEUKOCYTE; MACROPHAGE; MOUSE; MOUSE STRAIN; NATURAL KILLER CELL; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; PROVOCATION TEST; RESPIRATORY TRACT DISEASE; RESPIRATORY TRACT INFECTION; SHORT COURSE THERAPY; T LYMPHOCYTE; TREATMENT FAILURE; VACCINIA VIRUS; VIRUS INFECTION;

ANIMALS; HOMEODOMAIN PROTEINS; IMMUNIZATION; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; ORTHOPOXVIRUS; PNEUMONIA, VIRAL; POXVIRIDAE INFECTIONS; TIME FACTORS; VACCINIA VIRUS; VIRAL VACCINES;

ANIMALIA; ORTHOPOXVIRUS; VACCINIA VIRUS; VACCINIA VIRUS ANKARA; VARIOLA VIRUS;

EID: 33749077106     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/vir.0.82068-0     Document Type: Article

References (18)

1. Blanchard, T. J., Alcami, A., Andrea, P. & Smith, G. L. (1998). Modified vaccinia virus Ankara undergoes limited replication in human cells and lacks several immunomodulatory proteins: implications for use as a human vaccine. J Gen Virol 79, 1159-1167.
2. Drexler, I., Staib, C., Kastenmüller, W. & 8 other authors (2003). Identification of vaccinia virus epitope-specific HLA-A*0201-restricted T cells and comparative analysis of smallpox vaccines. Proc Natl Acad Sci U S A 100, 217-222.
3. Earl, P. L., Americo, J. L., Wyatt, L. S. & 15 other authors (2004). Immunogenicity of a highly attenuated MVA smallpox vaccine and protection against monkeypox. Nature 428, 182-185.
4. Fenner, F., Henderson, D. A., Arita, I., Jezek, Z. & Ladnyi, I. D. (1988). Smallpox and its Eradication. Geneva: World Health Organization.
5. Förster, R., Wolf, G. & Mayr, A. (1994). Highly attenuated poxviruses induce functional priming of neutrophils; in vitro. Arch Virol 136, 219-226.
6. Harrison, S. C., Alberts, B., Ehrenfeld, E. & 9 other authors (2004). Discovery of antivirals against smallpox. Proc Natl Acad Sci U S A 101, 11178-11192.
7. Hornemann, S., Harlin, O., Staib, C., Kisling, S., Erfle, V., Kaspers, B., Häcker, G. & Sutter, G. (2003). Replication of modified vaccinia virus Ankara in primary chicken embryo fibroblasts requires expression of the interferon resistance gene E3L. J Virol 77, 8394-8407.
8. Law, M., Pütz, M. M. & Smith, G. L. (2005). An investigation of the therapeutic value of vaccinia-immune IgG in a mouse pneumonia model. J Gen Virol 86, 991-1000.
9. Meseda, C. A., Garcia, A. D., Kumar, A., Mayer, A. E., Manischewitz, J., King, L. R., Golding, H., Merchlinsky, M. & Weir, J. P. (2005). Enhanced immunogenicity and protective effect conferred by vaccination with combinations of modified vaccinia virus Ankara and licensed smallpox vaccine Dryvax in a mouse model. Virology 339, 164-175.
10. Mombaerts, P., Iacomini, J., Johnson, R. S., Herrup, K., Tonegawa, S. & Papaioannou, V. E. (1992). RAG-1-deficient mice have no mature B and T lymphocytes. Cell 68, 869-877.
11. Mortimer, P. P. (2003). Can postexposure vaccination against smallpox succeed? Clin Infect Dis 36, 622-629.
12. Oie, K. L. & Pickup, D. J. (2001). Cowpox virus and other members of the orthopoxvirus genus interfere with the regulation of NF-κB activation. Virology 288, 175-187.
13. Rosenthal, S. R., Merchlinsky, M., Kleppinger, C. & Goldenthal, K. L. (2001). Developing new smallpox vaccines. Emerg Infect Dis 7, 920-926.
14. + T-cell memory responses elicited upon immunization with modified vaccinia virus Ankara. J Gen Virol 86, 1997-2006.
15. Stittelaar, K. J., van Amerongen, G., Kondova, I. & 9 other authors (2005). Modified vaccinia virus Ankara protects macaques against respiratory challenge with monkeypox virus. J Virol 79, 7845-7851.
16. Stittelaar, K. J., Neyts, J., Naesens, L. & 10 other authors (2006). Antiviral treatment is more effective than smallpox vaccination upon lethal monkeypox virus infection. Nature 439, 745-748.
17. Sutter, G. & Stalb, C. (2003). Vaccinia vectors as candidate vaccines: the development of modified vaccinia virus Ankara for antigen delivery. Curr Drug Targets Infect Disord 3, 263-271.
18. Wyatt, L. S., Earl, P. L., Eller, L. A. & Moss, B. (2004). Highly attenuated smallpox vaccine protects mice with and without immune deficiencies against pathogenic vaccinia virus challenge. Proc Natl Acad Sci U S A 101, 4590-4595.